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KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Abbreviations
- HUS
Definitions
- Thrombotic microangiopathy typically occurring after gastrointestinal infection with Shiga toxin-producing bacteria (classically E. coli O157:H7)
- Clinical triad of hemolytic anemia, thrombocytopenia, & acute renal failure following severe diarrhea
- Affected organ systems: Kidneys > CNS (20-50%) > gastrointestinal tract, heart
- Atypical form (HUS without coexisting disease) often due to dysregulation in alternative complement pathway
- Diarrhea less common; higher mortality
IMAGING
General Features
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Buder K et al: Neurodevelopmental long-term outcome in children after hemolytic uremic syndrome. Pediatr Nephrol. 30(3):503-13, 2015
- Keir LS: Shiga toxin associated hemolytic uremic syndrome. Hematol Oncol Clin North Am. 29(3):525-39, 2015
- Loirat C et al: An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol. ePub, 2015
- Hofer J et al: Extra-renal manifestations of complement-mediated thrombotic microangiopathies. Front Pediatr. 2:97, 2014
- Kaplan BS et al: Current treatment of atypical hemolytic uremic syndrome. Intractable Rare Dis Res. 3(2):34-45, 2014
- Gitiaux C et al: Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab. Dev Med Child Neurol. 55(8):758-65, 2013
- Glatstein M et al: Timing and utility of ultrasound in diarrhea-associated hemolytic uremic syndrome: 7-year experience of a large tertiary care hospital. Clin Pediatr (Phila). 49(5):418-21, 2010
- Toldo I et al: Diffusion-weighted imaging findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol. 24(2):247-50, 2009
- Scholbach TM: Changes of renal flow volume in the hemolytic-uremic syndrome--color Doppler sonographic investigations. Pediatr Nephrol. 16(8):644-7, 2001
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Abbreviations
- HUS
Definitions
- Thrombotic microangiopathy typically occurring after gastrointestinal infection with Shiga toxin-producing bacteria (classically E. coli O157:H7)
- Clinical triad of hemolytic anemia, thrombocytopenia, & acute renal failure following severe diarrhea
- Affected organ systems: Kidneys > CNS (20-50%) > gastrointestinal tract, heart
- Atypical form (HUS without coexisting disease) often due to dysregulation in alternative complement pathway
- Diarrhea less common; higher mortality
IMAGING
General Features
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Buder K et al: Neurodevelopmental long-term outcome in children after hemolytic uremic syndrome. Pediatr Nephrol. 30(3):503-13, 2015
- Keir LS: Shiga toxin associated hemolytic uremic syndrome. Hematol Oncol Clin North Am. 29(3):525-39, 2015
- Loirat C et al: An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol. ePub, 2015
- Hofer J et al: Extra-renal manifestations of complement-mediated thrombotic microangiopathies. Front Pediatr. 2:97, 2014
- Kaplan BS et al: Current treatment of atypical hemolytic uremic syndrome. Intractable Rare Dis Res. 3(2):34-45, 2014
- Gitiaux C et al: Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab. Dev Med Child Neurol. 55(8):758-65, 2013
- Glatstein M et al: Timing and utility of ultrasound in diarrhea-associated hemolytic uremic syndrome: 7-year experience of a large tertiary care hospital. Clin Pediatr (Phila). 49(5):418-21, 2010
- Toldo I et al: Diffusion-weighted imaging findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol. 24(2):247-50, 2009
- Scholbach TM: Changes of renal flow volume in the hemolytic-uremic syndrome--color Doppler sonographic investigations. Pediatr Nephrol. 16(8):644-7, 2001
