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Henoch-Schönlein Purpura
Michael R. Aquino, MD, MHSc
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Henoch-Schönlein purpura (HSP)
        • Synonyms

          • IgA vasculitis
        • Definitions

          • Systemic nonthrombocytopenic immune complex-mediated small vessel vasculitis

        IMAGING

        • General Features

          • GI Findings

            • Urologic Findings

              • Joint Findings

                • Neurologic Findings

                  • Pulmonary Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Du L et al: Multisystemic manifestations of IgA vasculitis. Clin Rheumatol. 40(1):43-52, 2020
                                    2. Singhal M et al: Imaging in small and medium vessel vasculitis. Int J Rheum Dis. 22 Suppl 1:78-85, 2019
                                    3. Fink AZ et al: Imaging findings in systemic childhood diseases presenting with dermatologic manifestations. Clin Imaging. 49:17-36, 2018
                                    4. Modi S et al: Acute scrotal swelling in Henoch-Schonlein purpura: case report and review of the literature. Urol Case Rep. 6:9-11, 2016
                                    5. Dalpiaz A et al: Urological manifestations of Henoch-Schonlein purpura: a review. Curr Urol. 8(2):66-73, 2015
                                    6. Kasahara K et al: Stenosing ureteritis in Henoch-Schönlein purpura: report of two cases. Pediatr Int. 57(2):317-20, 2015
                                    7. Khanna G et al: Pediatric vasculitis: recognizing multisystemic manifestations at body imaging. Radiographics. 35(3):849-65, 2015
                                    8. Lim Y et al: Henoch-Schonlein purpura: ultrasonography of scrotal and penile involvement. Ultrasonography. 34(2):144-7, 2015
                                    9. Pohl M: Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 30(2):245-52, 2015
                                    10. Stefek B et al: Henoch-Schönlein purpura with posterior reversible encephalopathy Syndrome. J Pediatr. 167(5):1152-4, 2015
                                    11. Rajagopala S et al: Pulmonary hemorrhage in Henoch-Schönlein purpura: case report and systematic review of the english literature. Semin Arthritis Rheum. 42(4):391-400, 2013
                                    12. Chen SY et al: Pulmonary hemorrhage associated with Henoch-Schönlein purpura in pediatric patients: case report and review of the literature. Semin Arthritis Rheum. 41(2):305-12, 2011
                                    13. McCarthy HJ et al: Clinical practice: Diagnosis and management of Henoch-Schönlein purpura. Eur J Pediatr. 169(6):643-50, 2010
                                    14. Ebert EC: Gastrointestinal manifestations of Henoch-Schonlein Purpura. Dig Dis Sci. 53(8):2011-9, 2008
                                    15. Nchimi A et al: Significance of bowel wall abnormalities at ultrasound in Henoch-Schönlein purpura. J Pediatr Gastroenterol Nutr. 46(1):48-53, 2008
                                    16. Narchi H: Risk of long term renal impairment and duration of follow up recommended for Henoch-Schonlein purpura with normal or minimal urinary findings: a systematic review. Arch Dis Child. 90(9):916-20, 2005
                                    17. Chang WL et al: Gastrointestinal manifestations in Henoch-Schonlein purpura: a review of 261 patients. Acta Paediatr. 93(11):1427-31, 2004
                                    18. Gedalia A: Henoch-Schonlein purpura. Curr Rheumatol Rep. 6(3):195-202, 2004
                                    19. Nadrous HF et al: Pulmonary involvement in Henoch-Schonlein purpura. Mayo Clin Proc. 79(9):1151-7, 2004
                                    20. Ronkainen J et al: The adult kidney 24 years after childhood Henoch-Schonlein purpura: a retrospective cohort study. Lancet. 360(9334):666-70, 2002
                                    21. Ben-Sira L et al: Severe scrotal pain in boys with Henoch-Schonlein purpura: incidence and sonography. Pediatr Radiol. 30(2):125-8, 2000
                                    22. Choong CK et al: Intra-abdominal manifestations of Henoch-Schönlein purpura. J Paediatr Child Health. 34(5):405-9, 1998
                                    23. Jeong YK et al: Gastrointestinal involvement in Henoch-Schonlein syndrome: CT findings. AJR Am J Roentgenol. 168(4):965-8, 1997
                                    24. Glasier CM et al: Henoch-Schonlein syndrome in children: gastrointestinal manifestations. AJR Am J Roentgenol. 136(6):1081-5, 1981
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Henoch-Schönlein purpura (HSP)
                                          • Synonyms

                                            • IgA vasculitis
                                          • Definitions

                                            • Systemic nonthrombocytopenic immune complex-mediated small vessel vasculitis

                                          IMAGING

                                          • General Features

                                            • GI Findings

                                              • Urologic Findings

                                                • Joint Findings

                                                  • Neurologic Findings

                                                    • Pulmonary Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Du L et al: Multisystemic manifestations of IgA vasculitis. Clin Rheumatol. 40(1):43-52, 2020
                                                                      2. Singhal M et al: Imaging in small and medium vessel vasculitis. Int J Rheum Dis. 22 Suppl 1:78-85, 2019
                                                                      3. Fink AZ et al: Imaging findings in systemic childhood diseases presenting with dermatologic manifestations. Clin Imaging. 49:17-36, 2018
                                                                      4. Modi S et al: Acute scrotal swelling in Henoch-Schonlein purpura: case report and review of the literature. Urol Case Rep. 6:9-11, 2016
                                                                      5. Dalpiaz A et al: Urological manifestations of Henoch-Schonlein purpura: a review. Curr Urol. 8(2):66-73, 2015
                                                                      6. Kasahara K et al: Stenosing ureteritis in Henoch-Schönlein purpura: report of two cases. Pediatr Int. 57(2):317-20, 2015
                                                                      7. Khanna G et al: Pediatric vasculitis: recognizing multisystemic manifestations at body imaging. Radiographics. 35(3):849-65, 2015
                                                                      8. Lim Y et al: Henoch-Schonlein purpura: ultrasonography of scrotal and penile involvement. Ultrasonography. 34(2):144-7, 2015
                                                                      9. Pohl M: Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 30(2):245-52, 2015
                                                                      10. Stefek B et al: Henoch-Schönlein purpura with posterior reversible encephalopathy Syndrome. J Pediatr. 167(5):1152-4, 2015
                                                                      11. Rajagopala S et al: Pulmonary hemorrhage in Henoch-Schönlein purpura: case report and systematic review of the english literature. Semin Arthritis Rheum. 42(4):391-400, 2013
                                                                      12. Chen SY et al: Pulmonary hemorrhage associated with Henoch-Schönlein purpura in pediatric patients: case report and review of the literature. Semin Arthritis Rheum. 41(2):305-12, 2011
                                                                      13. McCarthy HJ et al: Clinical practice: Diagnosis and management of Henoch-Schönlein purpura. Eur J Pediatr. 169(6):643-50, 2010
                                                                      14. Ebert EC: Gastrointestinal manifestations of Henoch-Schonlein Purpura. Dig Dis Sci. 53(8):2011-9, 2008
                                                                      15. Nchimi A et al: Significance of bowel wall abnormalities at ultrasound in Henoch-Schönlein purpura. J Pediatr Gastroenterol Nutr. 46(1):48-53, 2008
                                                                      16. Narchi H: Risk of long term renal impairment and duration of follow up recommended for Henoch-Schonlein purpura with normal or minimal urinary findings: a systematic review. Arch Dis Child. 90(9):916-20, 2005
                                                                      17. Chang WL et al: Gastrointestinal manifestations in Henoch-Schonlein purpura: a review of 261 patients. Acta Paediatr. 93(11):1427-31, 2004
                                                                      18. Gedalia A: Henoch-Schonlein purpura. Curr Rheumatol Rep. 6(3):195-202, 2004
                                                                      19. Nadrous HF et al: Pulmonary involvement in Henoch-Schonlein purpura. Mayo Clin Proc. 79(9):1151-7, 2004
                                                                      20. Ronkainen J et al: The adult kidney 24 years after childhood Henoch-Schonlein purpura: a retrospective cohort study. Lancet. 360(9334):666-70, 2002
                                                                      21. Ben-Sira L et al: Severe scrotal pain in boys with Henoch-Schonlein purpura: incidence and sonography. Pediatr Radiol. 30(2):125-8, 2000
                                                                      22. Choong CK et al: Intra-abdominal manifestations of Henoch-Schönlein purpura. J Paediatr Child Health. 34(5):405-9, 1998
                                                                      23. Jeong YK et al: Gastrointestinal involvement in Henoch-Schonlein syndrome: CT findings. AJR Am J Roentgenol. 168(4):965-8, 1997
                                                                      24. Glasier CM et al: Henoch-Schonlein syndrome in children: gastrointestinal manifestations. AJR Am J Roentgenol. 136(6):1081-5, 1981