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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Synonyms
- Hepatocellular adenoma (HCA)
Definitions
- Benign neoplasm arising from hepatocytes
- Risk of rupture/hemorrhage; rare malignant potential
- Different subtypes with different imaging features & clinical significance
- Inflammatory ~ 30-50%
- Hepatocyte nuclear factor 1α (HNF1α) mutated ~ 35-40%
- Also known as "L-FABP negative"
- More frequent fat content
- β-catenin activated ~ 10-19%
- ↑ malignant potential
- Undifferentiated ~ 5-10%
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Natural History & Prognosis
Treatment
Selected References
- Dhingra S et al: Update on the new classification of hepatic adenomas: clinical, molecular, and pathologic characteristics. Arch Pathol Lab Med. 138(8):1090-7, 2014
- van Aalten SM et al: Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification. Radiology. 261(1):172-81, 2011
- Chung EM et al: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics. 30(3):801-26, 2010
- Das CJ et al: Imaging of paediatric liver tumours with pathological correlation. Clin Radiol. 64(10):1015-25, 2009
- Jha P et al: Pediatric liver tumors--a pictorial review. Eur Radiol. 19(1):209-19, 2009
- Laumonier H et al: Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. 48(3):808-18, 2008
- Siegel MJ et al: Pediatric liver: focal masses. Magn Reson Imaging Clin N Am. 16(3):437-52, v, 2008
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Synonyms
- Hepatocellular adenoma (HCA)
Definitions
- Benign neoplasm arising from hepatocytes
- Risk of rupture/hemorrhage; rare malignant potential
- Different subtypes with different imaging features & clinical significance
- Inflammatory ~ 30-50%
- Hepatocyte nuclear factor 1α (HNF1α) mutated ~ 35-40%
- Also known as "L-FABP negative"
- More frequent fat content
- β-catenin activated ~ 10-19%
- ↑ malignant potential
- Undifferentiated ~ 5-10%
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Natural History & Prognosis
Treatment
Selected References
- Dhingra S et al: Update on the new classification of hepatic adenomas: clinical, molecular, and pathologic characteristics. Arch Pathol Lab Med. 138(8):1090-7, 2014
- van Aalten SM et al: Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification. Radiology. 261(1):172-81, 2011
- Chung EM et al: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics. 30(3):801-26, 2010
- Das CJ et al: Imaging of paediatric liver tumours with pathological correlation. Clin Radiol. 64(10):1015-25, 2009
- Jha P et al: Pediatric liver tumors--a pictorial review. Eur Radiol. 19(1):209-19, 2009
- Laumonier H et al: Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. 48(3):808-18, 2008
- Siegel MJ et al: Pediatric liver: focal masses. Magn Reson Imaging Clin N Am. 16(3):437-52, v, 2008
