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Hepatic Adenoma
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Hepatic adenoma (HA)
            • Synonyms

              • Hepatocellular adenoma, liver cell adenoma
            • Definitions

              • Heterogeneous group of benign hepatocellular neoplasms with distinctive genetic, pathologic, and clinical features

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Costa AF et al: Benign neoplasms, mass-like infections, and pseudotumors that mimic hepatic malignancy at MRI. J Magn Reson Imaging.53(4):979-94, 2021
                                                2. Auer TA et al: Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation? Eur Radiol. 30(6):3497-506, 2020
                                                3. Bise S et al: New MRI features improve subtype classification of hepatocellular adenoma. Eur Radiol. 29(5):2436-47, 2019
                                                4. Bisig AM et al: Classics in abdominal imaging: the atoll sign. Abdom Radiol (NY). 44(4):1621-2, 2019
                                                5. Cannella R et al: Value of texture analysis on gadoxetic acid-enhanced MRI for differentiating hepatocellular adenoma from focal nodular hyperplasia. AJR Am J Roentgenol. 212(3):538-46, 2019
                                                6. Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
                                                7. De Kock I et al: Hepatic adenomatosis: MR imaging features. JBR-BTR. 97(2):105-8, 2014
                                                8. Grazioli L et al: Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology. 262(2):520-9, 2012
                                                9. Katabathina VS et al: Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 31(6):1529-43, 2011
                                                10. Mounajjed T et al: Telangiectatic variant of hepatic adenoma: clinicopathologic features and correlation between liver needle biopsy and resection. Am J Surg Pathol. 35(9):1356-63, 2011
                                                11. Ji HF et al: Reduced-size liver transplantation for glycogen storage disease. Hepatobiliary Pancreat Dis Int. 8(1):106-8, 2009
                                                12. Kobayashi S et al: Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities. Jpn J Radiol. 27(2):53-68, 2009
                                                13. Santambrogio R et al: Liver transplantation for spontaneous intrapartum rupture of a hepatic adenoma. Obstet Gynecol. 113(2 Pt 2):508-10, 2009
                                                14. Furlan A et al: Multiple hepatic adenomas associated with liver steatosis at CT and MRI: a case-control study. AJR Am J Roentgenol. 191(5):1430-5, 2008
                                                15. Prasad SR et al: Fat-containing lesions of the liver: radiologic-pathologic correlation. Radiographics. 25(2):321-31, 2005
                                                16. Grazioli L et al: Hepatic adenomas: imaging and pathologic findings. Radiographics. 21(4):877-92; discussion 892-4, 2001
                                                17. Grazioli L et al: Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. 216(2):395-402, 2000
                                                18. Ichikawa T et al: Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. Radiology. 214(3):861-8, 2000
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Hepatic adenoma (HA)
                                                          • Synonyms

                                                            • Hepatocellular adenoma, liver cell adenoma
                                                          • Definitions

                                                            • Heterogeneous group of benign hepatocellular neoplasms with distinctive genetic, pathologic, and clinical features

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Angiographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Costa AF et al: Benign neoplasms, mass-like infections, and pseudotumors that mimic hepatic malignancy at MRI. J Magn Reson Imaging.53(4):979-94, 2021
                                                                                              2. Auer TA et al: Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation? Eur Radiol. 30(6):3497-506, 2020
                                                                                              3. Bise S et al: New MRI features improve subtype classification of hepatocellular adenoma. Eur Radiol. 29(5):2436-47, 2019
                                                                                              4. Bisig AM et al: Classics in abdominal imaging: the atoll sign. Abdom Radiol (NY). 44(4):1621-2, 2019
                                                                                              5. Cannella R et al: Value of texture analysis on gadoxetic acid-enhanced MRI for differentiating hepatocellular adenoma from focal nodular hyperplasia. AJR Am J Roentgenol. 212(3):538-46, 2019
                                                                                              6. Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
                                                                                              7. De Kock I et al: Hepatic adenomatosis: MR imaging features. JBR-BTR. 97(2):105-8, 2014
                                                                                              8. Grazioli L et al: Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology. 262(2):520-9, 2012
                                                                                              9. Katabathina VS et al: Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 31(6):1529-43, 2011
                                                                                              10. Mounajjed T et al: Telangiectatic variant of hepatic adenoma: clinicopathologic features and correlation between liver needle biopsy and resection. Am J Surg Pathol. 35(9):1356-63, 2011
                                                                                              11. Ji HF et al: Reduced-size liver transplantation for glycogen storage disease. Hepatobiliary Pancreat Dis Int. 8(1):106-8, 2009
                                                                                              12. Kobayashi S et al: Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities. Jpn J Radiol. 27(2):53-68, 2009
                                                                                              13. Santambrogio R et al: Liver transplantation for spontaneous intrapartum rupture of a hepatic adenoma. Obstet Gynecol. 113(2 Pt 2):508-10, 2009
                                                                                              14. Furlan A et al: Multiple hepatic adenomas associated with liver steatosis at CT and MRI: a case-control study. AJR Am J Roentgenol. 191(5):1430-5, 2008
                                                                                              15. Prasad SR et al: Fat-containing lesions of the liver: radiologic-pathologic correlation. Radiographics. 25(2):321-31, 2005
                                                                                              16. Grazioli L et al: Hepatic adenomas: imaging and pathologic findings. Radiographics. 21(4):877-92; discussion 892-4, 2001
                                                                                              17. Grazioli L et al: Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. 216(2):395-402, 2000
                                                                                              18. Ichikawa T et al: Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. Radiology. 214(3):861-8, 2000