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KEY FACTS
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Angiosarcoma (AGS)
Synonyms
- Hemangioendothelial sarcoma, hemangiosarcoma, Kupffer cell sarcoma
Definitions
- High-grade, aggressive mesenchymal malignancy composed of malignant endothelial cells of vascular or lymphatic origin in normal liver
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
- Liu Z et al: Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. BMC Med Imaging. 20(1):71, 2020
- Zeng D et al: A pooled analysis of primary hepatic angiosarcoma. Jpn J Clin Oncol. 50(5):556-67, 2020
- Cieszanowski A et al: Magnetic resonance imaging of uncommon hepatic mesenchymal tumours: haemangioendothelioma and angiosarcoma. Curr Med Imaging Rev. 15(4):362-8, 2019
- Yasir S et al: Angiosarcoma of the liver: clinicopathologic features and morphologic patterns. Am J Surg Pathol. 43(5):581-90, 2019
- Yi LL et al: CT and MRI studies of hepatic angiosarcoma. Clin Radiol. 74(5):406.e1-8, 2019
- Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
- Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
- Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
- Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
- Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
- Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
- Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
- Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
- Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
- Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
- Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
- Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
- White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Angiosarcoma (AGS)
Synonyms
- Hemangioendothelial sarcoma, hemangiosarcoma, Kupffer cell sarcoma
Definitions
- High-grade, aggressive mesenchymal malignancy composed of malignant endothelial cells of vascular or lymphatic origin in normal liver
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
- Liu Z et al: Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. BMC Med Imaging. 20(1):71, 2020
- Zeng D et al: A pooled analysis of primary hepatic angiosarcoma. Jpn J Clin Oncol. 50(5):556-67, 2020
- Cieszanowski A et al: Magnetic resonance imaging of uncommon hepatic mesenchymal tumours: haemangioendothelioma and angiosarcoma. Curr Med Imaging Rev. 15(4):362-8, 2019
- Yasir S et al: Angiosarcoma of the liver: clinicopathologic features and morphologic patterns. Am J Surg Pathol. 43(5):581-90, 2019
- Yi LL et al: CT and MRI studies of hepatic angiosarcoma. Clin Radiol. 74(5):406.e1-8, 2019
- Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
- Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
- Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
- Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
- Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
- Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
- Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
- Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
- Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
- Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
- Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
- Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
- White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993
