High-grade, aggressive mesenchymal malignancy composed of malignant endothelial cells of vascular or lymphatic origin in normal liver
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
Liu Z et al: Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. BMC Med Imaging. 20(1):71, 2020
Zeng D et al: A pooled analysis of primary hepatic angiosarcoma. Jpn J Clin Oncol. 50(5):556-67, 2020
Cieszanowski A et al: Magnetic resonance imaging of uncommon hepatic mesenchymal tumours: haemangioendothelioma and angiosarcoma. Curr Med Imaging Rev. 15(4):362-8, 2019
Yasir S et al: Angiosarcoma of the liver: clinicopathologic features and morphologic patterns. Am J Surg Pathol. 43(5):581-90, 2019
Yi LL et al: CT and MRI studies of hepatic angiosarcoma. Clin Radiol. 74(5):406.e1-8, 2019
Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993
High-grade, aggressive mesenchymal malignancy composed of malignant endothelial cells of vascular or lymphatic origin in normal liver
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
Liu Z et al: Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. BMC Med Imaging. 20(1):71, 2020
Zeng D et al: A pooled analysis of primary hepatic angiosarcoma. Jpn J Clin Oncol. 50(5):556-67, 2020
Cieszanowski A et al: Magnetic resonance imaging of uncommon hepatic mesenchymal tumours: haemangioendothelioma and angiosarcoma. Curr Med Imaging Rev. 15(4):362-8, 2019
Yasir S et al: Angiosarcoma of the liver: clinicopathologic features and morphologic patterns. Am J Surg Pathol. 43(5):581-90, 2019
Yi LL et al: CT and MRI studies of hepatic angiosarcoma. Clin Radiol. 74(5):406.e1-8, 2019
Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
Chung EM et al: From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993
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