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Hepatic Angiosarcoma
Michael P. Federle, MD, FACR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Angiosarcoma (AGS)
          • Synonyms

            • Hemangioendothelial sarcoma, hemangiosarcoma, Kupffer cell sarcoma

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
                                            2. Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
                                            3. Chung EM et al: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
                                            4. Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
                                            5. Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
                                            6. Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
                                            7. Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
                                            8. Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
                                            9. Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
                                            10. Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
                                            11. Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
                                            12. Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
                                            13. White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Angiosarcoma (AGS)
                                                    • Synonyms

                                                      • Hemangioendothelial sarcoma, hemangiosarcoma, Kupffer cell sarcoma

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Angiographic Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Groeschl RT et al: Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol. 109(5):483-6, 2014
                                                                                      2. Orlando G et al: Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience. Transplantation. 95(6):872-7, 2013
                                                                                      3. Chung EM et al: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 31(2):483-507, 2011
                                                                                      4. Geramizadeh B et al: Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 46(1):e9-11, 2011
                                                                                      5. Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
                                                                                      6. Schwartz J et al: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol. 25(5):1016, 2010
                                                                                      7. Zhou YM et al: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit. 16(2):CR61-6, 2010
                                                                                      8. Deyrup AT et al: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 33(2):264-9, 2009
                                                                                      9. Maeda T et al: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol. 188(6):1615-7, 2007
                                                                                      10. Kitami M et al: Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 27(4):626-9, 2003
                                                                                      11. Koyama T et al: Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 222(3):667-73, 2002
                                                                                      12. Peterson MS et al: Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 175(1):165-70, 2000
                                                                                      13. White PG et al: The computed tomographic appearances of angiosarcoma of the liver. Clin Radiol. 48(5):321-5, 1993