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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Definitions
- Regenerative response to chronic inflammation and hepatocyte injury → excessive accumulation of extracellular matrix proteins, such as collagen → hepatic fibrosis
- Most common etiologies
- Nonalcoholic fatty liver disease (NAFLD)
- Chronic hepatitis C virus (HCV) infection
- Alcoholic liver disease
- Quantifying liver fibrosis can predict outcome and guide treatment
- Early diagnosis is crucial to halt progression to cirrhosis and its potential complications including hepatocellular carcinoma (HCC) and portal hypertension
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
Selected References
- Barr RG et al: Update to the Society of Radiologists in Ultrasound liver elastography consensus statement. Radiology. 296(2):263-74, 2020
- Furlan A et al: Comparison of 2D shear wave elastography, transient elastography, and MR elastography for the diagnosis of fibrosis in patients with nonalcoholic fatty liver disease. AJR Am J Roentgenol. 214(1):W20-6, 2020
- Pirmoazen AM et al: Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease. Theranostics. 10(9):4277-89, 2020
- Horowitz JM et al: Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel. Abdom Radiol (NY). 42(8):2037-53, 2017
- Lin YS: Ultrasound evaluation of liver fibrosis. J Med Ultrasound. 25(3):127-9, 2017
- Beland MD et al: A pilot study estimating liver fibrosis with ultrasound shear-wave elastography: does the cause of liver disease or location of measurement affect performance? AJR Am J Roentgenol. 203(3):W267-73, 2014
- D'Onofrio M et al: Acoustic radiation force impulse of the liver. World J Gastroenterol. 19(30):4841-9, 2013
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Definitions
- Regenerative response to chronic inflammation and hepatocyte injury → excessive accumulation of extracellular matrix proteins, such as collagen → hepatic fibrosis
- Most common etiologies
- Nonalcoholic fatty liver disease (NAFLD)
- Chronic hepatitis C virus (HCV) infection
- Alcoholic liver disease
- Quantifying liver fibrosis can predict outcome and guide treatment
- Early diagnosis is crucial to halt progression to cirrhosis and its potential complications including hepatocellular carcinoma (HCC) and portal hypertension
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
Selected References
- Barr RG et al: Update to the Society of Radiologists in Ultrasound liver elastography consensus statement. Radiology. 296(2):263-74, 2020
- Furlan A et al: Comparison of 2D shear wave elastography, transient elastography, and MR elastography for the diagnosis of fibrosis in patients with nonalcoholic fatty liver disease. AJR Am J Roentgenol. 214(1):W20-6, 2020
- Pirmoazen AM et al: Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease. Theranostics. 10(9):4277-89, 2020
- Horowitz JM et al: Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel. Abdom Radiol (NY). 42(8):2037-53, 2017
- Lin YS: Ultrasound evaluation of liver fibrosis. J Med Ultrasound. 25(3):127-9, 2017
- Beland MD et al: A pilot study estimating liver fibrosis with ultrasound shear-wave elastography: does the cause of liver disease or location of measurement affect performance? AJR Am J Roentgenol. 203(3):W267-73, 2014
- D'Onofrio M et al: Acoustic radiation force impulse of the liver. World J Gastroenterol. 19(30):4841-9, 2013
