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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Injury to liver induced by exogenous toxins, either through direct hepatotoxicity or idiosyncratic reaction
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Wang H et al: Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 10(15):6715-27, 2020
- Fisher ES et al: Evaluation and treatment of acetaminophen toxicity. Adv Pharmacol. 85:263-72, 2019
- Pecnik P et al: High liver density on CT imaging due to amiodarone toxicity. Wien Klin Wochenschr. 130(5-6):220-1, 2018
- Heard K et al: A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clin Toxicol (Phila). 52(5):512-8, 2014
- Bunchorntavakul C et al: Acetaminophen-related hepatotoxicity. Clin Liver Dis. 17(4):587-607, viii, 2013
- Corsini A et al: Drug-induced liver injury: the role of drug metabolism and transport. J Clin Pharmacol. 53(5):463-74, 2013
- Shah AD et al: Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. Br J Clin Pharmacol. 71(1):20-8, 2011
- Ikeda T: Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case. Drug Metab Pharmacokinet. 26(1):60-70, 2011
- Akman SA et al: Liver transplantation for acute liver failure due to toxic agent ingestion in children. Pediatr Transplant. 2009 Dec;13(8):1034-40. Epub 2009 Feb 6. Erratum in: Pediatr Transplant. 14(8):1041, 2010
- Giri S et al: Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 6(8):895-917, 2010
- Kim HR et al: Occupational hepatic disorders in Korea. J Korean Med Sci. 25(Suppl):S36-40, 2010
- Senior JR: Unintended hepatic adverse events associated with cancer chemotherapy. Toxicol Pathol. 38(1):142-7, 2010
- Teschke R: Kava hepatotoxicity: pathogenetic aspects and prospective considerations. Liver Int. 30(9):1270-9, 2010
- Carlsen KM et al: Toxic hepatitis induced by infliximab in a patient with rheumatoid arthritis with no relapse after switching to etanercept. Clin Rheumatol. 28(8):1001-3, 2009
- Gemcitabine: cutaneous, hepatic and vascular disorders. Prescrire Int. 18(101):122, 2009
- Grattagliano I et al: Biochemical mechanisms in drug-induced liver injury: certainties and doubts. World J Gastroenterol. 15(39):4865-76, 2009
- Larson AM: Acetaminophen hepatotoxicity. Clin Liver Dis. 11(3):525-48, vi, 2007
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Injury to liver induced by exogenous toxins, either through direct hepatotoxicity or idiosyncratic reaction
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Wang H et al: Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 10(15):6715-27, 2020
- Fisher ES et al: Evaluation and treatment of acetaminophen toxicity. Adv Pharmacol. 85:263-72, 2019
- Pecnik P et al: High liver density on CT imaging due to amiodarone toxicity. Wien Klin Wochenschr. 130(5-6):220-1, 2018
- Heard K et al: A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clin Toxicol (Phila). 52(5):512-8, 2014
- Bunchorntavakul C et al: Acetaminophen-related hepatotoxicity. Clin Liver Dis. 17(4):587-607, viii, 2013
- Corsini A et al: Drug-induced liver injury: the role of drug metabolism and transport. J Clin Pharmacol. 53(5):463-74, 2013
- Shah AD et al: Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. Br J Clin Pharmacol. 71(1):20-8, 2011
- Ikeda T: Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case. Drug Metab Pharmacokinet. 26(1):60-70, 2011
- Akman SA et al: Liver transplantation for acute liver failure due to toxic agent ingestion in children. Pediatr Transplant. 2009 Dec;13(8):1034-40. Epub 2009 Feb 6. Erratum in: Pediatr Transplant. 14(8):1041, 2010
- Giri S et al: Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 6(8):895-917, 2010
- Kim HR et al: Occupational hepatic disorders in Korea. J Korean Med Sci. 25(Suppl):S36-40, 2010
- Senior JR: Unintended hepatic adverse events associated with cancer chemotherapy. Toxicol Pathol. 38(1):142-7, 2010
- Teschke R: Kava hepatotoxicity: pathogenetic aspects and prospective considerations. Liver Int. 30(9):1270-9, 2010
- Carlsen KM et al: Toxic hepatitis induced by infliximab in a patient with rheumatoid arthritis with no relapse after switching to etanercept. Clin Rheumatol. 28(8):1001-3, 2009
- Gemcitabine: cutaneous, hepatic and vascular disorders. Prescrire Int. 18(101):122, 2009
- Grattagliano I et al: Biochemical mechanisms in drug-induced liver injury: certainties and doubts. World J Gastroenterol. 15(39):4865-76, 2009
- Larson AM: Acetaminophen hepatotoxicity. Clin Liver Dis. 11(3):525-48, vi, 2007
