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Hepatic Sarcoidosis
Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Boeck sarcoid
          • Definitions

            • Relatively common, chronic, multisystem disease of unknown origin characterized by presence of noncaseating epithelioid granulomas

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    • Other Modality Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Cremers J et al: Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 24(1):17-24, 2012
                                            2. Spagnolo P et al: Sarcoidosis: challenging diagnostic aspects of an old disease. Am J Med. 125(2):118-25, 2012
                                            3. Ghani AA et al: Isolated sarcoid renal granulomatous tubulointerstitial disease. Saudi J Kidney Dis Transpl. 22(6):1208-10, 2011
                                            4. Hamzeh N: Sarcoidosis. Med Clin North Am. 95(6):1223-34, 2011
                                            5. Raber EL et al: Splenic sarcoidosis: a case report and review of the imaging findings of multiple incidental splenic lesions as the initial presentation of sarcoidosis. Can J Gastroenterol. 25(9):477-8, 2011
                                            6. Treglia G et al: Emerging role of whole-body 18F-fluorodeoxyglucose positron emission tomography as a marker of disease activity in patients with sarcoidosis: a systematic review. Sarcoidosis Vasc Diffuse Lung Dis. 28(2):87-94, 2011
                                            7. Elsayes KM et al: MR imaging of the spleen: spectrum of abnormalities. Radiographics. 25(4):967-82, 2005
                                            8. Koyama T et al: Radiologic manifestations of sarcoidosis in various organs. Radiographics. 24(1):87-104, 2004
                                            9. Amarapurkar DN et al: Hepatic sarcoidosis. Indian J Gastroenterol. 22(3):98-100, 2003
                                            10. Sartori S et al: Sonographically guided biopsy and sonographic monitoring in the diagnosis and follow-up of 2 cases of sarcoidosis with hepatic nodules and inconclusive thoracic findings. J Ultrasound Med. 21(9):1035-9, 2002
                                            11. Scott GC et al: CT patterns of nodular hepatic and splenic sarcoidosis: a review of the literature. J Comput Assist Tomogr. 21(3):369-72, 1997
                                            12. Warshauer DM et al: Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 192(1):93-8, 1994
                                            13. Britt AR et al: Sarcoidosis: abdominal manifestations at CT. Radiology. 178(1):91-4, 1991
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Boeck sarcoid
                                                    • Definitions

                                                      • Relatively common, chronic, multisystem disease of unknown origin characterized by presence of noncaseating epithelioid granulomas

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Other Modality Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Cremers J et al: Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 24(1):17-24, 2012
                                                                                      2. Spagnolo P et al: Sarcoidosis: challenging diagnostic aspects of an old disease. Am J Med. 125(2):118-25, 2012
                                                                                      3. Ghani AA et al: Isolated sarcoid renal granulomatous tubulointerstitial disease. Saudi J Kidney Dis Transpl. 22(6):1208-10, 2011
                                                                                      4. Hamzeh N: Sarcoidosis. Med Clin North Am. 95(6):1223-34, 2011
                                                                                      5. Raber EL et al: Splenic sarcoidosis: a case report and review of the imaging findings of multiple incidental splenic lesions as the initial presentation of sarcoidosis. Can J Gastroenterol. 25(9):477-8, 2011
                                                                                      6. Treglia G et al: Emerging role of whole-body 18F-fluorodeoxyglucose positron emission tomography as a marker of disease activity in patients with sarcoidosis: a systematic review. Sarcoidosis Vasc Diffuse Lung Dis. 28(2):87-94, 2011
                                                                                      7. Elsayes KM et al: MR imaging of the spleen: spectrum of abnormalities. Radiographics. 25(4):967-82, 2005
                                                                                      8. Koyama T et al: Radiologic manifestations of sarcoidosis in various organs. Radiographics. 24(1):87-104, 2004
                                                                                      9. Amarapurkar DN et al: Hepatic sarcoidosis. Indian J Gastroenterol. 22(3):98-100, 2003
                                                                                      10. Sartori S et al: Sonographically guided biopsy and sonographic monitoring in the diagnosis and follow-up of 2 cases of sarcoidosis with hepatic nodules and inconclusive thoracic findings. J Ultrasound Med. 21(9):1035-9, 2002
                                                                                      11. Scott GC et al: CT patterns of nodular hepatic and splenic sarcoidosis: a review of the literature. J Comput Assist Tomogr. 21(3):369-72, 1997
                                                                                      12. Warshauer DM et al: Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 192(1):93-8, 1994
                                                                                      13. Britt AR et al: Sarcoidosis: abdominal manifestations at CT. Radiology. 178(1):91-4, 1991