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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Sinusoidal obstruction syndrome
Definitions
- Therapy-induced occlusion of hepatic sinusoids, → clinical triad of jaundice, ascites, & painful hepatomegaly
- Onset within 30 days of stem cell transplantation (SCT)
- Secondary to myeloablative chemotherapy &/or irradiation preceding SCT
- May also occur with specific tumor chemotherapy regimens
- Wilms, rhabdomyosarcoma, leukemia most frequent
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Keating GM: Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation. Clin Drug Investig. 34(12):895-904, 2014
- Kotecha RS et al: Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. J Pediatr Hematol Oncol. 36(1):76-80, 2014
- Richardson PG et al: Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol Blood Marrow Transplant. 19(1 Suppl):S88-90, 2013
- Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
- Cefalo MG et al: Hepatic veno-occlusive disease: a chemotherapy-related toxicity in children with malignancies. Paediatr Drugs. 12(5):277-84, 2010
- Lee SH et al: Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Bone Marrow Transplant. 45(8):1287-93, 2010
- Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
- Ghersin E et al: Color Doppler demonstration of segmental portal flow reversal: an early sign of hepatic veno-occlusive disease in an infant. J Ultrasound Med. 22(10):1103-6, 2003
- Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
- McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
- Deeg KH et al: Diagnosis of veno-occlusive disease of the liver by color-coded Doppler sonography. Pediatr Radiol. 23(2):134-6, 1993
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Sinusoidal obstruction syndrome
Definitions
- Therapy-induced occlusion of hepatic sinusoids, → clinical triad of jaundice, ascites, & painful hepatomegaly
- Onset within 30 days of stem cell transplantation (SCT)
- Secondary to myeloablative chemotherapy &/or irradiation preceding SCT
- May also occur with specific tumor chemotherapy regimens
- Wilms, rhabdomyosarcoma, leukemia most frequent
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Keating GM: Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation. Clin Drug Investig. 34(12):895-904, 2014
- Kotecha RS et al: Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. J Pediatr Hematol Oncol. 36(1):76-80, 2014
- Richardson PG et al: Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol Blood Marrow Transplant. 19(1 Suppl):S88-90, 2013
- Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
- Cefalo MG et al: Hepatic veno-occlusive disease: a chemotherapy-related toxicity in children with malignancies. Paediatr Drugs. 12(5):277-84, 2010
- Lee SH et al: Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Bone Marrow Transplant. 45(8):1287-93, 2010
- Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
- Ghersin E et al: Color Doppler demonstration of segmental portal flow reversal: an early sign of hepatic veno-occlusive disease in an infant. J Ultrasound Med. 22(10):1103-6, 2003
- Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
- McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
- Deeg KH et al: Diagnosis of veno-occlusive disease of the liver by color-coded Doppler sonography. Pediatr Radiol. 23(2):134-6, 1993
