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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Sinusoidal obstruction syndrome
Definitions
Therapy-induced occlusion of hepatic sinusoids, → clinical triad of jaundice, ascites, & painful hepatomegaly
Onset within 30 days of stem cell transplantation (SCT)
Secondary to myeloablative chemotherapy &/or irradiation preceding SCT
May also occur with specific tumor chemotherapy regimens
Wilms, rhabdomyosarcoma, leukemia most frequent
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Keating GM: Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation. Clin Drug Investig. 34(12):895-904, 2014
Kotecha RS et al: Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. J Pediatr Hematol Oncol. 36(1):76-80, 2014
Richardson PG et al: Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol Blood Marrow Transplant. 19(1 Suppl):S88-90, 2013
Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
Cefalo MG et al: Hepatic veno-occlusive disease: a chemotherapy-related toxicity in children with malignancies. Paediatr Drugs. 12(5):277-84, 2010
Lee SH et al: Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Bone Marrow Transplant. 45(8):1287-93, 2010
Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
Ghersin E et al: Color Doppler demonstration of segmental portal flow reversal: an early sign of hepatic veno-occlusive disease in an infant. J Ultrasound Med. 22(10):1103-6, 2003
Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
Deeg KH et al: Diagnosis of veno-occlusive disease of the liver by color-coded Doppler sonography. Pediatr Radiol. 23(2):134-6, 1993
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Sinusoidal obstruction syndrome
Definitions
Therapy-induced occlusion of hepatic sinusoids, → clinical triad of jaundice, ascites, & painful hepatomegaly
Onset within 30 days of stem cell transplantation (SCT)
Secondary to myeloablative chemotherapy &/or irradiation preceding SCT
May also occur with specific tumor chemotherapy regimens
Wilms, rhabdomyosarcoma, leukemia most frequent
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Keating GM: Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation. Clin Drug Investig. 34(12):895-904, 2014
Kotecha RS et al: Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature. J Pediatr Hematol Oncol. 36(1):76-80, 2014
Richardson PG et al: Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol Blood Marrow Transplant. 19(1 Suppl):S88-90, 2013
Mahgerefteh SY et al: Radiologic imaging and intervention for gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. Radiology. 258(3):660-71, 2011
Cefalo MG et al: Hepatic veno-occlusive disease: a chemotherapy-related toxicity in children with malignancies. Paediatr Drugs. 12(5):277-84, 2010
Lee SH et al: Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Bone Marrow Transplant. 45(8):1287-93, 2010
Erturk SM et al: CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 186(6):1497-501, 2006
Ghersin E et al: Color Doppler demonstration of segmental portal flow reversal: an early sign of hepatic veno-occlusive disease in an infant. J Ultrasound Med. 22(10):1103-6, 2003
Lassau N et al: Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation. 74(1):60-6, 2002
McCarville MB et al: Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol. 31(2):102-5, 2001
Deeg KH et al: Diagnosis of veno-occlusive disease of the liver by color-coded Doppler sonography. Pediatr Radiol. 23(2):134-6, 1993
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