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Obstetrics
Diagnosis
Abdominal Wall and Gastrointestinal Tract
Hepatobiliary Abnormalities
Hepatoblastoma
Hepatoblastoma
Paula J. Woodward, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Malignant embryonic hepatic tumor composed of epithelial cells and occasionally mixture of epithelial and mesenchymal cells
                • Most common primary malignancy

            IMAGING

            • Ultrasonographic Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              Selected References

                              1. Yoo GHY et al: Rare cause of emergency in the first week of life: congenital hepatoblastoma (case report). Oxf Med Case Reports. 2020(2):omaa002, 2020
                              2. Zivot A et al: Congenital hepatoblastoma and Beckwith-Wiedemann syndrome. J Pediatr Hematol Oncol. 42(8):e798-800, 2020
                              3. Ofoegbu BN et al: Congenital hepatoblastoma in a growing health economy. BMJ Case Rep. 12(3), 2019
                              4. Sharma D et al: Hepatoblastoma. Semin Diagn Pathol. 34(2):192-200, 2017
                              5. Langham MR Jr et al: Current management of neonatal liver tumors. Curr Pediatr Rev. 11(3):195-204, 2015
                              6. Miura Y et al: Diagnosis and treatment of a preterm infant with inoperable congenital hepatoblastoma--a case report. J Pediatr Hematol Oncol. 37(3):e188-90, 2015
                              7. Nagaraj UD et al: Diagnostic imaging of fetal and neonatal abdominal and soft tissue tumors. Curr Pediatr Rev. 11(3):143-50, 2015
                              8. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010
                              9. Isaacs H Jr: Fetal and neonatal hepatic tumors. J Pediatr Surg. 42(11):1797-803, 2007
                              10. Jamieson DH: Focal hepatic lesions in neonates. Pediatr Radiol. 36(5):468, 2006
                              11. Aviram R et al: Prenatal imaging of fetal hepatoblastoma. J Matern Fetal Neonatal Med. 17(2):157-9, 2005
                              12. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                              13. Shih JC et al: Congenital hepatoblastoma. Ultrasound Obstet Gynecol. 16(1):103, 2000
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Definitions

                                          • Malignant embryonic hepatic tumor composed of epithelial cells and occasionally mixture of epithelial and mesenchymal cells
                                            • Most common primary malignancy

                                        IMAGING

                                        • Ultrasonographic Findings

                                          • Imaging Recommendations

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • General Features

                                                • Microscopic Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          Selected References

                                                          1. Yoo GHY et al: Rare cause of emergency in the first week of life: congenital hepatoblastoma (case report). Oxf Med Case Reports. 2020(2):omaa002, 2020
                                                          2. Zivot A et al: Congenital hepatoblastoma and Beckwith-Wiedemann syndrome. J Pediatr Hematol Oncol. 42(8):e798-800, 2020
                                                          3. Ofoegbu BN et al: Congenital hepatoblastoma in a growing health economy. BMJ Case Rep. 12(3), 2019
                                                          4. Sharma D et al: Hepatoblastoma. Semin Diagn Pathol. 34(2):192-200, 2017
                                                          5. Langham MR Jr et al: Current management of neonatal liver tumors. Curr Pediatr Rev. 11(3):195-204, 2015
                                                          6. Miura Y et al: Diagnosis and treatment of a preterm infant with inoperable congenital hepatoblastoma--a case report. J Pediatr Hematol Oncol. 37(3):e188-90, 2015
                                                          7. Nagaraj UD et al: Diagnostic imaging of fetal and neonatal abdominal and soft tissue tumors. Curr Pediatr Rev. 11(3):143-50, 2015
                                                          8. Makin E et al: Fetal and neonatal liver tumours. Early Hum Dev. 86(10):637-42, 2010
                                                          9. Isaacs H Jr: Fetal and neonatal hepatic tumors. J Pediatr Surg. 42(11):1797-803, 2007
                                                          10. Jamieson DH: Focal hepatic lesions in neonates. Pediatr Radiol. 36(5):468, 2006
                                                          11. Aviram R et al: Prenatal imaging of fetal hepatoblastoma. J Matern Fetal Neonatal Med. 17(2):157-9, 2005
                                                          12. Woodward PJ et al: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 25(1):215-42, 2005
                                                          13. Shih JC et al: Congenital hepatoblastoma. Ultrasound Obstet Gynecol. 16(1):103, 2000