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Hepatoblastoma
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Malignant embryonal hepatic tumor

          IMAGING

          • General Features

            • Radiographic Findings

              • Ultrasonographic Findings

                • MR Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Schooler GR et al: Pediatric hepatoblastoma, hepatocellular carcinoma, and other hepatic neoplasms: consensus imaging recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS) Working Group. Radiology. 296(3):493-7, 2020
                                            2. Towbin AJ et al: Fractures in children with newly diagnosed hepatoblastoma. Pediatr Radiol. 48(4):581-5, 2018
                                            3. Towbin AJ et al: 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol. 48(4):536-54, 2018
                                            4. Meyers RL et al: Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 18(1):122-31, 2017
                                            5. O'Neill AF et al: characterization of pulmonary metastases in children with hepatoblastoma treated on children's oncology group protocol ahep0731 (the treatment of children with all stages of hepatoblastoma): a report from the Children's Oncology Group. J Clin Oncol. 35(30):3465-73, 2017
                                            6. López-Terrada D et al: Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol. 27(3):472-91, 2014
                                            7. Meyers AB et al: Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI--typical, atypical, pre- and post-treatment evaluation. Pediatr Radiol. 42(7):859-66, 2012
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Malignant embryonal hepatic tumor

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • Ultrasonographic Findings

                                                          • MR Findings

                                                            • CT Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Schooler GR et al: Pediatric hepatoblastoma, hepatocellular carcinoma, and other hepatic neoplasms: consensus imaging recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS) Working Group. Radiology. 296(3):493-7, 2020
                                                                                      2. Towbin AJ et al: Fractures in children with newly diagnosed hepatoblastoma. Pediatr Radiol. 48(4):581-5, 2018
                                                                                      3. Towbin AJ et al: 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol. 48(4):536-54, 2018
                                                                                      4. Meyers RL et al: Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 18(1):122-31, 2017
                                                                                      5. O'Neill AF et al: characterization of pulmonary metastases in children with hepatoblastoma treated on children's oncology group protocol ahep0731 (the treatment of children with all stages of hepatoblastoma): a report from the Children's Oncology Group. J Clin Oncol. 35(30):3465-73, 2017
                                                                                      6. López-Terrada D et al: Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol. 27(3):472-91, 2014
                                                                                      7. Meyers AB et al: Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI--typical, atypical, pre- and post-treatment evaluation. Pediatr Radiol. 42(7):859-66, 2012