Enlargement of liver due to underlying pathologic process
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Ghadimi M et al: Advances in imaging of diffuse parenchymal liver disease. J Clin Gastroenterol. 54(8):682-95, 2020
Leao Filho H et al: Other types of diffuse liver disease: is there a way to do it? Abdom Radiol (NY). 45(11):3425-43, 2020
Thomaides-Brears HB et al: Multiparametric MR mapping in clinical decision-making for diffuse liver disease. Abdom Radiol (NY). 45(11):3507-22, 2020
Curtis WA et al: Quantitative MRI of diffuse liver disease: current applications and future directions. Radiology. 290(1):23-30, 2019
Mogrovejo E et al: Characterization of the syndrome of acute liver failure caused by metastases from breast carcinoma. Dig Dis Sci. 59(4):724-36, 2014
Gao H et al: Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. J Dig Dis. 13(1):33-9, 2012
Gertz MA: How to manage primary amyloidosis. Leukemia. 26(2):191-8, 2012
Udell JA et al: Does this patient with liver disease have cirrhosis? JAMA. 307(8):832-42, 2012
Mallavarapu KM et al: Multiple myeloma presenting with hepatosplenomegaly. J Assoc Physicians India. 59:456-8, 2011
Patel M et al: Characterization of computed tomography scan abnormalities in patients with biopsy-proven hepatic metastases from uveal melanoma. Arch Ophthalmol. 129(12):1576-82, 2011
Valayannopoulos V et al: Successful treatment of severe cardiomyopathy in glycogen storage disease type III with D,L-3-hydroxybutyrate, ketogenic and high-protein diet. Pediatr Res. 70(6):638-41, 2011
Weitz N et al: Education and imaging. Gastrointestinal: metastatic ocular melanoma causing massive hepatomegaly. J Gastroenterol Hepatol. 26(10):1577, 2011
Wilson S et al: Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis. Parasite Immunol. 31(2):64-71, 2009
Wilson S et al: Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection. Trop Med Int Health. 12(12):1442-9, 2007
Oliva MR et al: Computed tomography features of nonalcoholic steatohepatitis with histopathologic correlation. J Comput Assist Tomogr. 30(1):37-43, 2006
van Hoek B: Non-alcoholic fatty liver disease: a brief review. Scand J Gastroenterol Suppl. (241):56-9, 2004
Grazioli L et al: Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. 216(2):395-402, 2000
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KEY FACTS
Terminology
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TERMINOLOGY
Definitions
Enlargement of liver due to underlying pathologic process
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Ghadimi M et al: Advances in imaging of diffuse parenchymal liver disease. J Clin Gastroenterol. 54(8):682-95, 2020
Leao Filho H et al: Other types of diffuse liver disease: is there a way to do it? Abdom Radiol (NY). 45(11):3425-43, 2020
Thomaides-Brears HB et al: Multiparametric MR mapping in clinical decision-making for diffuse liver disease. Abdom Radiol (NY). 45(11):3507-22, 2020
Curtis WA et al: Quantitative MRI of diffuse liver disease: current applications and future directions. Radiology. 290(1):23-30, 2019
Mogrovejo E et al: Characterization of the syndrome of acute liver failure caused by metastases from breast carcinoma. Dig Dis Sci. 59(4):724-36, 2014
Gao H et al: Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. J Dig Dis. 13(1):33-9, 2012
Gertz MA: How to manage primary amyloidosis. Leukemia. 26(2):191-8, 2012
Udell JA et al: Does this patient with liver disease have cirrhosis? JAMA. 307(8):832-42, 2012
Mallavarapu KM et al: Multiple myeloma presenting with hepatosplenomegaly. J Assoc Physicians India. 59:456-8, 2011
Patel M et al: Characterization of computed tomography scan abnormalities in patients with biopsy-proven hepatic metastases from uveal melanoma. Arch Ophthalmol. 129(12):1576-82, 2011
Valayannopoulos V et al: Successful treatment of severe cardiomyopathy in glycogen storage disease type III with D,L-3-hydroxybutyrate, ketogenic and high-protein diet. Pediatr Res. 70(6):638-41, 2011
Weitz N et al: Education and imaging. Gastrointestinal: metastatic ocular melanoma causing massive hepatomegaly. J Gastroenterol Hepatol. 26(10):1577, 2011
Wilson S et al: Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis. Parasite Immunol. 31(2):64-71, 2009
Wilson S et al: Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection. Trop Med Int Health. 12(12):1442-9, 2007
Oliva MR et al: Computed tomography features of nonalcoholic steatohepatitis with histopathologic correlation. J Comput Assist Tomogr. 30(1):37-43, 2006
van Hoek B: Non-alcoholic fatty liver disease: a brief review. Scand J Gastroenterol Suppl. (241):56-9, 2004
Grazioli L et al: Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. 216(2):395-402, 2000
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