link
Bookmarks
Heterotopic Gray Matter
Charles Raybaud, MD, FRCPC
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
8
13
1

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Abbreviations

            • Heterotopia (HTP); malformations of cortical development (MCD)
          • Synonyms

            • Gray matter heterotopia; double cortex = band HTP
          • Definitions

            • Heterotopias: Group of MCD characterized by presence of excessive neurons (either isolated or clustered) in subcortical white matter (WM)
              • Reflects arrested/disrupted migration of groups of neurons anywhere from periventricular germinal zone (GZ) to cortex

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Pardoe HR et al: Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia. Epilepsy Res. 109:40-7, 2015
                                            2. Sarnat HB et al: Timing in Neural Maturation: Arrest, Delay, Precociousness, and Temporal Determination of Malformations. Pediatr Neurol. 52(5):473-486, 2015
                                            3. Bahi-Buisson N et al: New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain. 136(Pt 1):223-44, 2013
                                            4. Conti V et al: Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene. Brain. 136(Pt 11):3378-94, 2013
                                            5. 1: Aronica E, Becker AJ, Spreafico R. Malformations of cortical development. Brain Pathol. 2012 May;22(3):380-401. doi: 10.1111/j.1750-3639.2012.00581.x. Review. PubMed PMID: 22497611.
                                            6. Barkovich AJ et al: A developmental and genetic classification for malformations of cortical development: update 2012. Brain. 135(Pt 5):1348-69, 2012
                                            7. Pisano T et al: Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology. 79(12):1244-51, 2012
                                            8. Guerrini R et al: Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options. Trends Neurosci. 31(3):154-62, 2008
                                            9. Widjaja E et al: Evaluation of subcortical white matter and deep white matter tracts in malformations of cortical development. Epilepsia. 48(8):1460-9, 2007
                                            10. Eriksson SH et al: Exploring white matter tracts in band heterotopia using diffusion tractography. Ann Neurol. 52(3):327-34, 2002
                                            11. Barkovich AJ et al: Gray matter heterotopia. Neurology. 55(11):1603-8, 2000
                                            12. Barkovich AJ: Morphologic characteristics of subcortical heterotopia: MR imaging study. AJNR Am J Neuroradiol. 21(2):290-5, 2000
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Heterotopia (HTP); malformations of cortical development (MCD)
                                                    • Synonyms

                                                      • Gray matter heterotopia; double cortex = band HTP
                                                    • Definitions

                                                      • Heterotopias: Group of MCD characterized by presence of excessive neurons (either isolated or clustered) in subcortical white matter (WM)
                                                        • Reflects arrested/disrupted migration of groups of neurons anywhere from periventricular germinal zone (GZ) to cortex

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Pardoe HR et al: Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia. Epilepsy Res. 109:40-7, 2015
                                                                                      2. Sarnat HB et al: Timing in Neural Maturation: Arrest, Delay, Precociousness, and Temporal Determination of Malformations. Pediatr Neurol. 52(5):473-486, 2015
                                                                                      3. Bahi-Buisson N et al: New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain. 136(Pt 1):223-44, 2013
                                                                                      4. Conti V et al: Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene. Brain. 136(Pt 11):3378-94, 2013
                                                                                      5. 1: Aronica E, Becker AJ, Spreafico R. Malformations of cortical development. Brain Pathol. 2012 May;22(3):380-401. doi: 10.1111/j.1750-3639.2012.00581.x. Review. PubMed PMID: 22497611.
                                                                                      6. Barkovich AJ et al: A developmental and genetic classification for malformations of cortical development: update 2012. Brain. 135(Pt 5):1348-69, 2012
                                                                                      7. Pisano T et al: Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology. 79(12):1244-51, 2012
                                                                                      8. Guerrini R et al: Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options. Trends Neurosci. 31(3):154-62, 2008
                                                                                      9. Widjaja E et al: Evaluation of subcortical white matter and deep white matter tracts in malformations of cortical development. Epilepsia. 48(8):1460-9, 2007
                                                                                      10. Eriksson SH et al: Exploring white matter tracts in band heterotopia using diffusion tractography. Ann Neurol. 52(3):327-34, 2002
                                                                                      11. Barkovich AJ et al: Gray matter heterotopia. Neurology. 55(11):1603-8, 2000
                                                                                      12. Barkovich AJ: Morphologic characteristics of subcortical heterotopia: MR imaging study. AJNR Am J Neuroradiol. 21(2):290-5, 2000