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Heterotopic Ossification
Umesh D. Oza, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Heterotopic ossification (HO)
          • Definitions

            • Extraskeletal osteogenesis
              • Typically (though not necessarily) in muscle
              • Tendons, fascia (fasciitis ossificans), subcutaneous fat
            • Acquired: Ectopic ossification, myositis ossificans circumscripta/traumatica
            • Hereditary: Atraumatic HO, fibrodysplasia ossificans progressiva (FOP)/myositis ossificans progressiva (MOP), Münchmeyer disease

          IMAGING

          • General Features

            • Nuclear Medicine Findings

              • Radiographic Findings

                • CT Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Nauth A et al: Heterotopic ossification in orthopaedic trauma. J Orthop Trauma. 26(12):684-8, 2012
                                          2. Vavken P et al: Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery. Arch Orthop Trauma Surg. 131(9):1309-15, 2011
                                          3. Crundwell N et al: Non-neoplastic conditions presenting as soft-tissue tumours. Clin Radiol. 62(1):18-27, 2007
                                          4. Shehab D et al: Heterotopic ossification. J Nucl Med. 43(3):346-53, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Heterotopic ossification (HO)
                                                  • Definitions

                                                    • Extraskeletal osteogenesis
                                                      • Typically (though not necessarily) in muscle
                                                      • Tendons, fascia (fasciitis ossificans), subcutaneous fat
                                                    • Acquired: Ectopic ossification, myositis ossificans circumscripta/traumatica
                                                    • Hereditary: Atraumatic HO, fibrodysplasia ossificans progressiva (FOP)/myositis ossificans progressiva (MOP), Münchmeyer disease

                                                  IMAGING

                                                  • General Features

                                                    • Nuclear Medicine Findings

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Nauth A et al: Heterotopic ossification in orthopaedic trauma. J Orthop Trauma. 26(12):684-8, 2012
                                                                                  2. Vavken P et al: Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery. Arch Orthop Trauma Surg. 131(9):1309-15, 2011
                                                                                  3. Crundwell N et al: Non-neoplastic conditions presenting as soft-tissue tumours. Clin Radiol. 62(1):18-27, 2007
                                                                                  4. Shehab D et al: Heterotopic ossification. J Nucl Med. 43(3):346-53, 2002