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Heterotopic Pregnancy
Karen Y. Oh, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • 2 concurrent pregnancies, at least 1 of which is ectopic in location
                  • Tubal, cervical, interstitial, abdominal, cesarean scar implantation
                • Most commonly 1 intrauterine pregnancy (IUP) with tubal ectopic pregnancy
                  • Triplet heterotopic pregnancies reported

              IMAGING

              • General Features

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                Selected References

                                1. Avitabile NC et al: Two cases of heterotopic pregnancy: review of the literature and sonographic diagnosis in the emergency department. J Ultrasound Med. 34(3):527-30, 2015
                                2. Perkins KM et al: Risk of ectopic pregnancy associated with assisted reproductive technology in the United States, 2001-2011. Obstet Gynecol. 125(1):70-8, 2015
                                3. OuYang Z et al: Heterotopic cesarean scar pregnancy: diagnosis, treatment, and prognosis. J Ultrasound Med. 33(9):1533-7, 2014
                                4. Savelli L et al: Heterotopic interstitial pregnancy successfully treated with ultrasound-guided potassium chloride injection in the ectopic embryo. J Obstet Gynaecol. 34(3):276-7, 2014
                                5. Talbot K et al: Heterotopic pregnancy. J Obstet Gynaecol. 31(1):7-12, 2011
                                6. Lavanya R et al: Successful pregnancy following medical management of heterotopic pregnancy. J Hum Reprod Sci. 2(1):35-40, 2009
                                7. Luo X et al: Heterotopic pregnancy following in vitro fertilization and embryo transfer: 12 cases report. Arch Gynecol Obstet. 280(2):325-9, 2009
                                8. Clayton HB et al: A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002. Fertil Steril. 87(2):303-9, 2007
                                9. Rabbani I et al: Heterotopic pregnancy is not rare. A case report and literature review. J Obstet Gynaecol. 25(2):204-5, 2005
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Definitions

                                              • 2 concurrent pregnancies, at least 1 of which is ectopic in location
                                                • Tubal, cervical, interstitial, abdominal, cesarean scar implantation
                                              • Most commonly 1 intrauterine pregnancy (IUP) with tubal ectopic pregnancy
                                                • Triplet heterotopic pregnancies reported

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Avitabile NC et al: Two cases of heterotopic pregnancy: review of the literature and sonographic diagnosis in the emergency department. J Ultrasound Med. 34(3):527-30, 2015
                                                              2. Perkins KM et al: Risk of ectopic pregnancy associated with assisted reproductive technology in the United States, 2001-2011. Obstet Gynecol. 125(1):70-8, 2015
                                                              3. OuYang Z et al: Heterotopic cesarean scar pregnancy: diagnosis, treatment, and prognosis. J Ultrasound Med. 33(9):1533-7, 2014
                                                              4. Savelli L et al: Heterotopic interstitial pregnancy successfully treated with ultrasound-guided potassium chloride injection in the ectopic embryo. J Obstet Gynaecol. 34(3):276-7, 2014
                                                              5. Talbot K et al: Heterotopic pregnancy. J Obstet Gynaecol. 31(1):7-12, 2011
                                                              6. Lavanya R et al: Successful pregnancy following medical management of heterotopic pregnancy. J Hum Reprod Sci. 2(1):35-40, 2009
                                                              7. Luo X et al: Heterotopic pregnancy following in vitro fertilization and embryo transfer: 12 cases report. Arch Gynecol Obstet. 280(2):325-9, 2009
                                                              8. Clayton HB et al: A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002. Fertil Steril. 87(2):303-9, 2007
                                                              9. Rabbani I et al: Heterotopic pregnancy is not rare. A case report and literature review. J Obstet Gynaecol. 25(2):204-5, 2005