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HHV-6 Encephalitis
Miral D. Jhaveri, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Human herpes virus 6 (HHV-6) encephalitis
              • Definitions

                • Encephalitis caused by HHV-6

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Ward KN: Child and adult forms of human herpesvirus 6 encephalitis: looking back, looking forward. Curr Opin Neurol. 27(3):349-55, 2014
                                          2. Bhanushali MJ et al: Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. Neurology. 80(16):1494-500, 2013
                                          3. Nath A et al: Novel approaches and challenges to treatment of central nervous system viral infections. Ann Neurol. 74(3):412-22, 2013
                                          4. Solbrig MV: Diagnosing encephalitis? Consider human herpesvirus type 6. Ann Neurol. 65(3):235-7, 2009
                                          5. Yao K et al: Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol. 65(3):257-67, 2009
                                          6. Gewurz BE et al: Human herpesvirus 6 encephalitis. Curr Infect Dis Rep. 10(4):292-9, 2008
                                          7. Provenzale JM et al: Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. Radiology. 249(3):955-63, 2008
                                          8. Baskin HJ et al: Neuroimaging of herpesvirus infections in children. Pediatr Radiol. 37(10):949-63, 2007
                                          9. Crawford JR et al: Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol. 22(11):1260-8, 2007
                                          10. Seeley WW et al: Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 69(2):156-65, 2007
                                          11. Vu T et al: Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 39(11):705-9, 2007
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Human herpes virus 6 (HHV-6) encephalitis
                                                      • Definitions

                                                        • Encephalitis caused by HHV-6

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Ward KN: Child and adult forms of human herpesvirus 6 encephalitis: looking back, looking forward. Curr Opin Neurol. 27(3):349-55, 2014
                                                                                  2. Bhanushali MJ et al: Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. Neurology. 80(16):1494-500, 2013
                                                                                  3. Nath A et al: Novel approaches and challenges to treatment of central nervous system viral infections. Ann Neurol. 74(3):412-22, 2013
                                                                                  4. Solbrig MV: Diagnosing encephalitis? Consider human herpesvirus type 6. Ann Neurol. 65(3):235-7, 2009
                                                                                  5. Yao K et al: Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol. 65(3):257-67, 2009
                                                                                  6. Gewurz BE et al: Human herpesvirus 6 encephalitis. Curr Infect Dis Rep. 10(4):292-9, 2008
                                                                                  7. Provenzale JM et al: Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. Radiology. 249(3):955-63, 2008
                                                                                  8. Baskin HJ et al: Neuroimaging of herpesvirus infections in children. Pediatr Radiol. 37(10):949-63, 2007
                                                                                  9. Crawford JR et al: Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol. 22(11):1260-8, 2007
                                                                                  10. Seeley WW et al: Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 69(2):156-65, 2007
                                                                                  11. Vu T et al: Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 39(11):705-9, 2007