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Hibernoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Lipoma of immature adipose tissue, lipoma of embryonic fat, fetal lipoma
            • Definitions

              • Rare, benign adipocytic tumor demonstrating brown fat differentiation

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Rosenburg AE et al: Lipoma and hibernoma of bone. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 475-7, 2020
                                                  2. Johnson CN et al: Lipomatous soft-tissue tumors. J Am Acad Orthop Surg. 26(22):779-88, 2018
                                                  3. Bonar SF et al: Intraosseous hibernoma: characterization of five cases and literature review. Skeletal Radiol. 43(7):939-46, 2014
                                                  4. Hedayati V et al: MEN1 syndrome and hibernoma: an uncommonly recognised association? Case Rep Med. 2014:804580, 2014
                                                  5. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 128-31, 2014
                                                  6. Botchu R et al: Intraosseous hibernoma: a case report and review of the literature. Skeletal Radiol. 42(7):1003-5, 2013
                                                  7. Liu W et al: Hibernoma: comparing imaging appearance with more commonly encountered benign or low-grade lipomatous neoplasms. Skeletal Radiol. 42(8):1073-8, 2013
                                                  8. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 466-70, 2008
                                                  9. Lewandowski PJ et al: Hibernoma of the medial thigh. Case report and literature review. Clin Orthop Relat Res. (330):198-201, 1996
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Synonyms

                                                              • Lipoma of immature adipose tissue, lipoma of embryonic fat, fetal lipoma
                                                            • Definitions

                                                              • Rare, benign adipocytic tumor demonstrating brown fat differentiation

                                                            IMAGING

                                                            • General Features

                                                              • Imaging Recommendations

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Rosenburg AE et al: Lipoma and hibernoma of bone. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 475-7, 2020
                                                                                                  2. Johnson CN et al: Lipomatous soft-tissue tumors. J Am Acad Orthop Surg. 26(22):779-88, 2018
                                                                                                  3. Bonar SF et al: Intraosseous hibernoma: characterization of five cases and literature review. Skeletal Radiol. 43(7):939-46, 2014
                                                                                                  4. Hedayati V et al: MEN1 syndrome and hibernoma: an uncommonly recognised association? Case Rep Med. 2014:804580, 2014
                                                                                                  5. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 128-31, 2014
                                                                                                  6. Botchu R et al: Intraosseous hibernoma: a case report and review of the literature. Skeletal Radiol. 42(7):1003-5, 2013
                                                                                                  7. Liu W et al: Hibernoma: comparing imaging appearance with more commonly encountered benign or low-grade lipomatous neoplasms. Skeletal Radiol. 42(8):1073-8, 2013
                                                                                                  8. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 466-70, 2008
                                                                                                  9. Lewandowski PJ et al: Hibernoma of the medial thigh. Case report and literature review. Clin Orthop Relat Res. (330):198-201, 1996