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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Histiocytic necrotizing lymphadenitis (HNL)
Synonyms
- Kikuchi disease
- Kikuchi-Fujimoto disease
Definitions
- Necrotizing lymphadenitis with predominant histiocytic infiltration
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
- Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
- Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
- Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
- Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
- Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
- Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
- Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
- Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
- Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
- Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
- Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
- Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
- Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
- Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
- Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
- Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
- Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
- Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
- Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
- Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Histiocytic necrotizing lymphadenitis (HNL)
Synonyms
- Kikuchi disease
- Kikuchi-Fujimoto disease
Definitions
- Necrotizing lymphadenitis with predominant histiocytic infiltration
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
- Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
- Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
- Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
- Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
- Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
- Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
- Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
- Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
- Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
- Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
- Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
- Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
- Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
- Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
- Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
- Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
- Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
- Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
- Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
- Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997
