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Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease)
Eunice Y. L. Dai, MBBS, FRCR; Yolanda Y. P. Lee, MBChB, FRCR; Anil T. Ahuja, MD, FRCR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Histiocytic necrotizing lymphadenitis (HNL)
            • Synonyms

              • Kikuchi disease
              • Kikuchi-Fujimoto disease
            • Definitions

              • Necrotizing lymphadenitis with predominant histiocytic infiltration

            IMAGING

            • General Features

              • Imaging Recommendations

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
                                          2. Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
                                          3. Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
                                          4. Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
                                          5. Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
                                          6. Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
                                          7. Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
                                          8. Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
                                          9. Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
                                          10. Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
                                          11. Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
                                          12. Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
                                          13. Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
                                          14. Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
                                          15. Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
                                          16. Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
                                          17. Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
                                          18. Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
                                          19. Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
                                          20. Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
                                          21. Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Histiocytic necrotizing lymphadenitis (HNL)
                                                    • Synonyms

                                                      • Kikuchi disease
                                                      • Kikuchi-Fujimoto disease
                                                    • Definitions

                                                      • Necrotizing lymphadenitis with predominant histiocytic infiltration

                                                    IMAGING

                                                    • General Features

                                                      • Imaging Recommendations

                                                        • Ultrasonographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
                                                                                  2. Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
                                                                                  3. Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
                                                                                  4. Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
                                                                                  5. Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
                                                                                  6. Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
                                                                                  7. Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
                                                                                  8. Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
                                                                                  9. Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
                                                                                  10. Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
                                                                                  11. Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
                                                                                  12. Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
                                                                                  13. Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
                                                                                  14. Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
                                                                                  15. Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
                                                                                  16. Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
                                                                                  17. Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
                                                                                  18. Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
                                                                                  19. Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
                                                                                  20. Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
                                                                                  21. Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997