Necrotizing lymphadenitis with predominant histiocytic infiltration
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Histiocytic necrotizing lymphadenitis (HNL)
Synonyms
Kikuchi disease
Kikuchi-Fujimoto disease
Definitions
Necrotizing lymphadenitis with predominant histiocytic infiltration
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Kim JY et al: Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children. Ultrasonography. 36(1):66-70, 2017
Ryoo I et al: Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi disease. Korean J Radiol. 16(4):767-75, 2015
Ohta K et al: Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma. Breast Cancer. 20(1):97-101, 2013
Lee S et al: Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. AJNR Am J Neuroradiol. 33(1):135-40, 2012
Lo WC et al: Ultrasonographic differentiation between Kikuchi's disease and lymphoma in patients with cervical lymphadenopathy. Eur J Radiol. 81(8):1817-20, 2012
Yoo JL et al: Gray scale and power Doppler study of biopsy-proven Kikuchi disease. J Ultrasound Med. 30(7):957-63, 2011
Cunha BA et al: Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma. Heart Lung. 38(5):450-6, 2009
Ito K et al: F-18 FDG PET/CT findings showing lymph node uptake in patients with Kikuchi disease. Clin Nucl Med. 34(11):821-2, 2009
Lee DH et al: Disseminated Kikuchi-Fujimoto disease mimicking malignant lymphoma on positron emission tomography in a child. J Pediatr Hematol Oncol. 31(9):687-9, 2009
Nomura Y et al: Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis. Pathol Int. 59(9):631-5, 2009
Pilichowska ME et al: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): lesional cells exhibit an immature dendritic cell phenotype. Am J Clin Pathol. 131(2):174-82, 2009
Chase SP et al: Cervical lymphadenopathy secondary to Kikuchi-Fujimoto disease in a child: case report. Ear Nose Throat J. 87(6):350-3, 2008
Kaicker S et al: PET-CT scan in a patient with Kikuchi disease. Pediatr Radiol. 38(5):596-7, 2008
Kampitak T: Fatal Kikuchi-Fujimoto disease associated with SLE and hemophagocytic syndrome: a case report. Clin Rheumatol. 27(8):1073-5, 2008
Pace-Asciak P et al: Case series: raising awareness about Kikuchi-Fujimoto disease among otolaryngologists: is it linked to systemic lupus erythematosus? J Otolaryngol Head Neck Surg. 37(6):782-7, 2008
Papla B et al: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease). Pol J Pathol. 59(1):55-61, 2008
Youk JH et al: Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 27(6):847-53, 2008
Bosch X et al: Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 122(1):141-52, 2004
Kwon SY et al: CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 25(6):1099-102, 2004
Ying M et al: Grey-scale and power Doppler sonography of unusual cervical lymphadenopathy. Ultrasound Med Biol. 30(4):449-54, 2004
Na DG et al: Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 18(9):1729-32, 1997
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