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Histoplasmosis
Carlos S. Restrepo, MDHelen T. Winer-Muram, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Infection with dimorphic fungus Histoplasma capsulatum
              • Disease manifestations
                • Histoplasmoma
                • Acute, massive inhalational histoplasmosis
                • Acute disseminated histoplasmosis
                • Chronic pulmonary or mediastinal histoplasmosis
                • Fibrosing mediastinitis

            IMAGING

            • General Features

              • Radiographic Findings

                • Fluoroscopic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Diagnosis

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Baker J et al: Chronic pulmonary histoplasmosis-a scoping literature review. Open Forum Infect Dis. 7(5):ofaa119, 2020
                                            2. Di Mango AL et al: Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging. Expert Rev Respir Med. 13(3):263-77, 2019
                                            3. Semionov A et al: Many faces of thoracic histoplasmosis-pictorial essay. Can Assoc Radiol J. 70(3):273-81, 2019
                                            4. Salzer HJF et al: Diagnosis and management of systemic endemic mycoses causing pulmonary disease. Respiration. 96(3):283-301, 2018
                                            5. Richmond BW et al: Histoplasmomas of uncommon size. Chest. 143(6):1795-8, 2013
                                            6. Marom EM et al: Imaging studies for diagnosing invasive fungal pneumonia in immunocompromised patients. Curr Opin Infect Dis. 24(4):309-14, 2011
                                            7. Knox KS et al: Histoplasmosis. Proc Am Thorac Soc. 7(3):169-72, 2010
                                            8. Hage CA et al: Pulmonary histoplasmosis. Semin Respir Crit Care Med. 29(2):151-65, 2008
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Infection with dimorphic fungus Histoplasma capsulatum
                                                        • Disease manifestations
                                                          • Histoplasmoma
                                                          • Acute, massive inhalational histoplasmosis
                                                          • Acute disseminated histoplasmosis
                                                          • Chronic pulmonary or mediastinal histoplasmosis
                                                          • Fibrosing mediastinitis

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • Fluoroscopic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Diagnosis

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Baker J et al: Chronic pulmonary histoplasmosis-a scoping literature review. Open Forum Infect Dis. 7(5):ofaa119, 2020
                                                                                      2. Di Mango AL et al: Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging. Expert Rev Respir Med. 13(3):263-77, 2019
                                                                                      3. Semionov A et al: Many faces of thoracic histoplasmosis-pictorial essay. Can Assoc Radiol J. 70(3):273-81, 2019
                                                                                      4. Salzer HJF et al: Diagnosis and management of systemic endemic mycoses causing pulmonary disease. Respiration. 96(3):283-301, 2018
                                                                                      5. Richmond BW et al: Histoplasmomas of uncommon size. Chest. 143(6):1795-8, 2013
                                                                                      6. Marom EM et al: Imaging studies for diagnosing invasive fungal pneumonia in immunocompromised patients. Curr Opin Infect Dis. 24(4):309-14, 2011
                                                                                      7. Knox KS et al: Histoplasmosis. Proc Am Thorac Soc. 7(3):169-72, 2010
                                                                                      8. Hage CA et al: Pulmonary histoplasmosis. Semin Respir Crit Care Med. 29(2):151-65, 2008