Unexplained hypereosinophilia (> 1,500/μL) of ≥ 6 months duration associated with organ dysfunction due to eosinophilic infiltration
Heart is most commonly involved organ (cardiac involvement in up to 60% of cases)
IMAGING
General Features
Imaging Recommendations
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Moss AJ et al: A 56-year-old woman with breathlessness. Heart. 103(9):726, 2017
Mankad R et al: Hypereosinophilic syndrome: cardiac diagnosis and management. Heart. 102(2):100-6, 2016
Perazzolo Marra M et al: Cardiac magnetic resonance features of biopsy-proven endomyocardial diseases. JACC Cardiovasc Imaging. 7(3):309-12, 2014
Hoey ET et al: Cardiovascular MRI for assessment of infectious and inflammatory conditions of the heart. AJR Am J Roentgenol. 197(1):103-12, 2011
Kleinfeldt T et al: Cardiac manifestation of the hypereosinophilic syndrome: new insights. Clin Res Cardiol. 99(7):419-27, 2010
Ogbogu PU et al: Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 124(6):1319-25, 2009
Chao BH et al: Fatal Loeffler's endocarditis due to hypereosinophilic syndrome. Am J Hematol. 82(10):920-3, 2007
Klion AD et al: Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. J Allergy Clin Immunol. 117(6):1292-302, 2006
Cury RC et al: Images in cardiovascular medicine. Visualization of endomyocardial fibrosis by delayed-enhancement magnetic resonance imaging. Circulation. 111(9):e115-7, 2005
Salanitri GC: Endomyocardial fibrosis and intracardiac thrombus occurring in idiopathic hypereosinophilic syndrome. AJR Am J Roentgenol. 184(5):1432-3, 2005
Bishop GG et al: Hypereosinophilic syndrome and restrictive cardiomyopathy due to apical thrombi. Circulation. 104(2):E3-4, 2001
Puvaneswary M et al: Idiopathic hypereosinophilic syndrome: magnetic resonance imaging findings in endomyocardial fibrosis. Australas Radiol. 45(4):524-7, 2001
Ommen SR et al: Clinical and echocardiographic features of hypereosinophilic syndromes. Am J Cardiol. 86(1):110-3, 2000
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Abbreviations
Hypereosinophilic syndrome (HES)
Synonyms
Cardiac involvement in HES has many synonyms
Löffler (or Loeffler) endocarditis
Eosinophilic endomyocarditis
Nontropical eosinophilic endomyocardial disease
Definitions
Unexplained hypereosinophilia (> 1,500/μL) of ≥ 6 months duration associated with organ dysfunction due to eosinophilic infiltration
Heart is most commonly involved organ (cardiac involvement in up to 60% of cases)
IMAGING
General Features
Imaging Recommendations
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Moss AJ et al: A 56-year-old woman with breathlessness. Heart. 103(9):726, 2017
Mankad R et al: Hypereosinophilic syndrome: cardiac diagnosis and management. Heart. 102(2):100-6, 2016
Perazzolo Marra M et al: Cardiac magnetic resonance features of biopsy-proven endomyocardial diseases. JACC Cardiovasc Imaging. 7(3):309-12, 2014
Hoey ET et al: Cardiovascular MRI for assessment of infectious and inflammatory conditions of the heart. AJR Am J Roentgenol. 197(1):103-12, 2011
Kleinfeldt T et al: Cardiac manifestation of the hypereosinophilic syndrome: new insights. Clin Res Cardiol. 99(7):419-27, 2010
Ogbogu PU et al: Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 124(6):1319-25, 2009
Chao BH et al: Fatal Loeffler's endocarditis due to hypereosinophilic syndrome. Am J Hematol. 82(10):920-3, 2007
Klion AD et al: Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. J Allergy Clin Immunol. 117(6):1292-302, 2006
Cury RC et al: Images in cardiovascular medicine. Visualization of endomyocardial fibrosis by delayed-enhancement magnetic resonance imaging. Circulation. 111(9):e115-7, 2005
Salanitri GC: Endomyocardial fibrosis and intracardiac thrombus occurring in idiopathic hypereosinophilic syndrome. AJR Am J Roentgenol. 184(5):1432-3, 2005
Bishop GG et al: Hypereosinophilic syndrome and restrictive cardiomyopathy due to apical thrombi. Circulation. 104(2):E3-4, 2001
Puvaneswary M et al: Idiopathic hypereosinophilic syndrome: magnetic resonance imaging findings in endomyocardial fibrosis. Australas Radiol. 45(4):524-7, 2001
Ommen SR et al: Clinical and echocardiographic features of hypereosinophilic syndromes. Am J Cardiol. 86(1):110-3, 2000
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