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Hyperparathyroidism
Julia R. Crim, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Hyperparathyroidism (HPT)
              • Definitions

                • Increased levels of hyperparathyroid hormone
                • Osteitis fibrosa cystica: Florid bony changes due to longstanding HPT
                • Brown tumor: Reactive giant cell lesion due to HPT
                • HPT may be primary, secondary, or tertiary

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Other Modality Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Khalatbari MR et al: Brown tumor of the spine in patients with primary hyperparathyroidism. Spine (Phila Pa 1976). 39(18):E1073-9, 2014
                                        2. Araújo SM et al: Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism. Int Urol Nephrol. 45(3):913-6, 2013
                                        3. Lacativa PG et al: Prevalence of radiological findings among cases of severe secondary hyperparathyroidism. Sao Paulo Med J. 127(2):71-7, 2009
                                        4. Noman Zaheer S et al: Brown tumour of the spine in a renal transplant patient. J Clin Neurosci. 16(9):1230-2, 2009
                                        5. Lumachi F et al: Lumbar spine bone mineral density changes in patients with primary hyperparathyroidism according to age and gender. Ann N Y Acad Sci. 1117:362-6, 2007
                                        6. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                        7. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                        8. Cormier C et al: Hyperparathyroidism: the limits of surgery in cases of bone or cardiovascular involvement. Curr Opin Rheumatol. 12(4):349-53, 2000
                                        9. Adami S et al: Bone measurements in asymptomatic primary hyperparathyroidism. Bone. 22(5):565-70, 1998
                                        10. Barzilay J et al: Erosive spondyloarthropathy in primary hyperparathyroidism without renal failure. Am J Kidney Dis. 20(1):90-3, 1992
                                        11. Lafferty FW et al: Primary hyperparathyroidism. A review of the long-term surgical and nonsurgical morbidities as a basis for a rational approach to treatment. Arch Intern Med. 149(4):789-96, 1989
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Hyperparathyroidism (HPT)
                                                    • Definitions

                                                      • Increased levels of hyperparathyroid hormone
                                                      • Osteitis fibrosa cystica: Florid bony changes due to longstanding HPT
                                                      • Brown tumor: Reactive giant cell lesion due to HPT
                                                      • HPT may be primary, secondary, or tertiary

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Other Modality Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Khalatbari MR et al: Brown tumor of the spine in patients with primary hyperparathyroidism. Spine (Phila Pa 1976). 39(18):E1073-9, 2014
                                                                              2. Araújo SM et al: Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism. Int Urol Nephrol. 45(3):913-6, 2013
                                                                              3. Lacativa PG et al: Prevalence of radiological findings among cases of severe secondary hyperparathyroidism. Sao Paulo Med J. 127(2):71-7, 2009
                                                                              4. Noman Zaheer S et al: Brown tumour of the spine in a renal transplant patient. J Clin Neurosci. 16(9):1230-2, 2009
                                                                              5. Lumachi F et al: Lumbar spine bone mineral density changes in patients with primary hyperparathyroidism according to age and gender. Ann N Y Acad Sci. 1117:362-6, 2007
                                                                              6. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                                                              7. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                                                              8. Cormier C et al: Hyperparathyroidism: the limits of surgery in cases of bone or cardiovascular involvement. Curr Opin Rheumatol. 12(4):349-53, 2000
                                                                              9. Adami S et al: Bone measurements in asymptomatic primary hyperparathyroidism. Bone. 22(5):565-70, 1998
                                                                              10. Barzilay J et al: Erosive spondyloarthropathy in primary hyperparathyroidism without renal failure. Am J Kidney Dis. 20(1):90-3, 1992
                                                                              11. Lafferty FW et al: Primary hyperparathyroidism. A review of the long-term surgical and nonsurgical morbidities as a basis for a rational approach to treatment. Arch Intern Med. 149(4):789-96, 1989