Elicker BM et al: Multidisciplinary approach to hypersensitivity pneumonitis. J Thorac Imaging. 31(2):92-103, 2016
Magee AL et al: Imaging of Hypersensitivity Pneumonitis. Radiol Clin North Am. 54(6):1033-1046, 2016
Spagnolo P et al: Hypersensitivity pneumonitis: a comprehensive Review. J Investig Allergol Clin Immunol. 25(4):237-50; quiz follow 250, 2015
Jeong YJ et al: Chronic hypersensitivity pneumonitis and pulmonary sarcoidosis: differentiation from usual interstitial pneumonia using high-resolution computed tomography. Semin Ultrasound CT MR. 35(1):47-58, 2014
Lacasse Y et al: Recent advances in hypersensitivity pneumonitis. Chest. 142(1):208-17, 2012
Selman M et al: Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med. 186(4):314-24, 2012
Sverzellati N et al: Biopsy-proved idiopathic pulmonary fibrosis: spectrum of nondiagnostic thin-section CT diagnoses. Radiology. 254(3):957-64, 2010
Hirschmann JV et al: Hypersensitivity pneumonitis: a historical, clinical, and radiologic review. Radiographics. 29(7):1921-38, 2009
Lacasse Y et al: Classification of hypersensitivity pneumonitis: a hypothesis. Int Arch Allergy Immunol. 149(2):161-6, 2009
Hanak V et al: HRCT Findings of Parenchymal Fibrosis Correlate with Prognosis in Hypersensitivity Pneumonitis. Chest.
Olson AL et al: Acute exacerbations of fibrotic hypersensitivity pneumonitis: a case series. Chest. 134(4):844-50, 2008
Silva CI et al: Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 246(1):288-97, 2008
Takemura T et al: Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 14(5):440-54, 2008
Sahin H et al: Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival. Radiology. 244(2):591-8, 2007
Silva CI et al: Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. AJR Am J Roentgenol. 188(2):334-44, 2007
Lacasse Y et al: Hypersensitivity pneumonitis. Orphanet J Rare Dis. 1:25, 2006
Franquet et al: Lung cysts in subacute hypersensitivity pneumonitis. J Comput Assist Tomogr 27(4): 475-8, 2003
Lacasse Y et al: Clinical diagnosis of hypersensitivity pneumonitis. Am J Respir Crit Care Med. 168(8):952-8, 2003
Selman M et al: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 134(2):136-51, 2001
Tasaka S et al: Fatal diffuse alveolar damage from bird fanciers' lung. Respiration. 64(4):307-9, 1997
Akira M et al: Summer-type hypersensitivity pneumonitis: comparison of high-resolution CT and plain radiographic findings. AJR Am J Roentgenol. 158(6):1223-8, 1992
Richerson HB et al: Guidelines for the clinical evaluation of hypersensitivity pneumonitis. Report of the Subcommittee on Hypersensitivity Pneumonitis. J Allergy Clin Immunol. 84(5 Pt 2):839-44, 1989
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
Hypersensitivity pneumonitis (HP)
Idiopathic pulmonary fibrosis (IPF)
Synonyms
Extrinsic allergic alveolitis
Bird fancier's lung
Pigeon breeder or pigeon fancier disease
Farmer's lung
Bat lung
Animal handler's lung
Laboratory worker's lung
Miller's lung
Lycoperdonosis
Hot tub lung
Definitions
Allergic inflammatory response of lungs and airways to inhaled organic antigens or haptens (i.e., low molecular weight inorganic molecules)
Type of cellular bronchiolitis
HP may manifest with transitory pulmonary opacities or irreversible pulmonary fibrosis
Historically classified as acute, subacute, and chronic types (Richerson classification)
Predates availability of HRCT
Imaging and pathologic findings were extrapolated to fit clinical findings, but were never statistically validated
New classification proposes 2 clusters that incorporate clinical, imaging, and pathologic findings
Cluster 1: Symptoms occur hours after exposure and may be recurrent
Elicker BM et al: Multidisciplinary approach to hypersensitivity pneumonitis. J Thorac Imaging. 31(2):92-103, 2016
Magee AL et al: Imaging of Hypersensitivity Pneumonitis. Radiol Clin North Am. 54(6):1033-1046, 2016
Spagnolo P et al: Hypersensitivity pneumonitis: a comprehensive Review. J Investig Allergol Clin Immunol. 25(4):237-50; quiz follow 250, 2015
Jeong YJ et al: Chronic hypersensitivity pneumonitis and pulmonary sarcoidosis: differentiation from usual interstitial pneumonia using high-resolution computed tomography. Semin Ultrasound CT MR. 35(1):47-58, 2014
Lacasse Y et al: Recent advances in hypersensitivity pneumonitis. Chest. 142(1):208-17, 2012
Selman M et al: Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med. 186(4):314-24, 2012
Sverzellati N et al: Biopsy-proved idiopathic pulmonary fibrosis: spectrum of nondiagnostic thin-section CT diagnoses. Radiology. 254(3):957-64, 2010
Hirschmann JV et al: Hypersensitivity pneumonitis: a historical, clinical, and radiologic review. Radiographics. 29(7):1921-38, 2009
Lacasse Y et al: Classification of hypersensitivity pneumonitis: a hypothesis. Int Arch Allergy Immunol. 149(2):161-6, 2009
Hanak V et al: HRCT Findings of Parenchymal Fibrosis Correlate with Prognosis in Hypersensitivity Pneumonitis. Chest.
Olson AL et al: Acute exacerbations of fibrotic hypersensitivity pneumonitis: a case series. Chest. 134(4):844-50, 2008
Silva CI et al: Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 246(1):288-97, 2008
Takemura T et al: Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 14(5):440-54, 2008
Sahin H et al: Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival. Radiology. 244(2):591-8, 2007
Silva CI et al: Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. AJR Am J Roentgenol. 188(2):334-44, 2007
Lacasse Y et al: Hypersensitivity pneumonitis. Orphanet J Rare Dis. 1:25, 2006
Franquet et al: Lung cysts in subacute hypersensitivity pneumonitis. J Comput Assist Tomogr 27(4): 475-8, 2003
Lacasse Y et al: Clinical diagnosis of hypersensitivity pneumonitis. Am J Respir Crit Care Med. 168(8):952-8, 2003
Selman M et al: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 134(2):136-51, 2001
Tasaka S et al: Fatal diffuse alveolar damage from bird fanciers' lung. Respiration. 64(4):307-9, 1997
Akira M et al: Summer-type hypersensitivity pneumonitis: comparison of high-resolution CT and plain radiographic findings. AJR Am J Roentgenol. 158(6):1223-8, 1992
Richerson HB et al: Guidelines for the clinical evaluation of hypersensitivity pneumonitis. Report of the Subcommittee on Hypersensitivity Pneumonitis. J Allergy Clin Immunol. 84(5 Pt 2):839-44, 1989
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