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Hypertrophic Osteoarthropathy
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Hypertrophic osteoarthropathy (HOA)
          • Synonyms

            • Hypertrophic pulmonary osteoarthropathy; acropachy; secondary HOA; Marie-Bamberger syndrome
            • Primary HOA = pachydermoperiostosis
          • Definitions

            • Syndrome characterized by proliferation of skin (1°) and bone (1° and 2°) in distal extremities

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Li S et al: Primary hypertrophic osteoarthropathy with myelofibrosis and anemia: a case report and review of literature. Int J Clin Exp Med. 8(1):1467-71, 2015
                                      2. Tüysüz B et al: Primary hypertrophic osteoarthropathy caused by homozygous deletion in HPGD gene in a family: changing clinical and radiological findings with long-term follow-up. Rheumatol Int. 34(11):1539-44, 2014
                                      3. Booth TC et al: Update on imaging of non-infectious musculoskeletal complications of HIV infection. Skeletal Radiol. 41(11):1349-63, 2012
                                      4. Drakonaki EE et al: Ten-year-old boy with finger and toe swelling. Skeletal Radiol. 41(8):1003, 2012
                                      5. Drakonaki EE et al: Hypertrophic osteoarthropathy in a child due to thoracic Hodgkin's disease. Skeletal Radiol. 41(8):1027-8, 2012
                                      6. Ede K et al: Hypertrophic osteoarthropathy in the hepatopulmonary syndrome. J Clin Rheumatol. 14(4):230-3, 2008
                                      7. Martinez-Lavin M et al: Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. Curr Opin Rheumatol. 20(1):88-91, 2008
                                      8. Narla VV et al: Atypical presentation of hypertrophic pulmonary osteoarthropathy on Tc-99m MDP bone scintigraphy. Clin Nucl Med. 33(10):702-4, 2008
                                      9. Armstrong DJ et al: Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie-Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature. Rheumatol Int. 27(4):399-402, 2007
                                      10. McNaughton DA et al: AJR teaching file: Cavitated mass with hypertrophic osteoarthropathy. AJR Am J Roentgenol. 188(3 Suppl):S7-9, 2007
                                      11. Bachmeyer C et al: Myelofibrosis in a patient with pachydermoperiostosis. Clin Exp Dermatol. 30(6):646-8, 2005
                                      12. Castori M et al: Pachydermoperiostosis: an update. Clin Genet. 68(6):477-86, 2005
                                      13. Karadeniz C et al: Hypertrophic osteoarthropathy and childhood Hodgkin disease. Pediatr Hematol Oncol. 18(1):79-82, 2001
                                      14. Mito K et al: Hypertrophic pulmonary osteoarthropathy associated with non-small cell lung cancer demonstrated growth hormone-releasing hormone by immunohistochemical analysis. Intern Med. 40(6):532-5, 2001
                                      15. Martínez-Lavín M: Hypertrophic osteoarthropathy. Curr Opin Rheumatol. 9(1):83-6, 1997
                                      16. Gunnarsson G et al: Hypertrophic osteoarthropathy associated with Pneumocystis carinii pneumonia and human immunodeficiency virus infection. Clin Infect Dis. 22(3):590-1, 1996
                                      17. Pineda CJ et al: Periostitis in hypertrophic osteoarthropathy: relationship to disease duration. AJR Am J Roentgenol. 148(4):773-8, 1987
                                      18. Resnick D: Re: Radiographic features of osteoarthropathy. Radiology. 157(2):553-4, 1985
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Hypertrophic osteoarthropathy (HOA)
                                              • Synonyms

                                                • Hypertrophic pulmonary osteoarthropathy; acropachy; secondary HOA; Marie-Bamberger syndrome
                                                • Primary HOA = pachydermoperiostosis
                                              • Definitions

                                                • Syndrome characterized by proliferation of skin (1°) and bone (1° and 2°) in distal extremities

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Li S et al: Primary hypertrophic osteoarthropathy with myelofibrosis and anemia: a case report and review of literature. Int J Clin Exp Med. 8(1):1467-71, 2015
                                                                          2. Tüysüz B et al: Primary hypertrophic osteoarthropathy caused by homozygous deletion in HPGD gene in a family: changing clinical and radiological findings with long-term follow-up. Rheumatol Int. 34(11):1539-44, 2014
                                                                          3. Booth TC et al: Update on imaging of non-infectious musculoskeletal complications of HIV infection. Skeletal Radiol. 41(11):1349-63, 2012
                                                                          4. Drakonaki EE et al: Ten-year-old boy with finger and toe swelling. Skeletal Radiol. 41(8):1003, 2012
                                                                          5. Drakonaki EE et al: Hypertrophic osteoarthropathy in a child due to thoracic Hodgkin's disease. Skeletal Radiol. 41(8):1027-8, 2012
                                                                          6. Ede K et al: Hypertrophic osteoarthropathy in the hepatopulmonary syndrome. J Clin Rheumatol. 14(4):230-3, 2008
                                                                          7. Martinez-Lavin M et al: Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. Curr Opin Rheumatol. 20(1):88-91, 2008
                                                                          8. Narla VV et al: Atypical presentation of hypertrophic pulmonary osteoarthropathy on Tc-99m MDP bone scintigraphy. Clin Nucl Med. 33(10):702-4, 2008
                                                                          9. Armstrong DJ et al: Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie-Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature. Rheumatol Int. 27(4):399-402, 2007
                                                                          10. McNaughton DA et al: AJR teaching file: Cavitated mass with hypertrophic osteoarthropathy. AJR Am J Roentgenol. 188(3 Suppl):S7-9, 2007
                                                                          11. Bachmeyer C et al: Myelofibrosis in a patient with pachydermoperiostosis. Clin Exp Dermatol. 30(6):646-8, 2005
                                                                          12. Castori M et al: Pachydermoperiostosis: an update. Clin Genet. 68(6):477-86, 2005
                                                                          13. Karadeniz C et al: Hypertrophic osteoarthropathy and childhood Hodgkin disease. Pediatr Hematol Oncol. 18(1):79-82, 2001
                                                                          14. Mito K et al: Hypertrophic pulmonary osteoarthropathy associated with non-small cell lung cancer demonstrated growth hormone-releasing hormone by immunohistochemical analysis. Intern Med. 40(6):532-5, 2001
                                                                          15. Martínez-Lavín M: Hypertrophic osteoarthropathy. Curr Opin Rheumatol. 9(1):83-6, 1997
                                                                          16. Gunnarsson G et al: Hypertrophic osteoarthropathy associated with Pneumocystis carinii pneumonia and human immunodeficiency virus infection. Clin Infect Dis. 22(3):590-1, 1996
                                                                          17. Pineda CJ et al: Periostitis in hypertrophic osteoarthropathy: relationship to disease duration. AJR Am J Roentgenol. 148(4):773-8, 1987
                                                                          18. Resnick D: Re: Radiographic features of osteoarthropathy. Radiology. 157(2):553-4, 1985