Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Hypothalamic hamartoma (HH), diencephalic hamartoma
Definitions
- Nonneoplastic congenital gray matter heterotopia in region of tuber cinereum
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Du VX et al: Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma? Epilepsia. 58 Suppl 2:77-84, 2017
- Harrison VS et al: Hypothalamic hamartoma with epilepsy: review of endocrine comorbidity. Epilepsia. 58 Suppl 2:50-9, 2017
- Scholly J et al: Hypothalamic hamartoma: epileptogenesis beyond the lesion? Epilepsia. 58 Suppl 2:32-40, 2017
- Rolston JD et al: Stereotactic laser ablation for hypothalamic hamartoma. Neurosurg Clin N Am. 27(1):59-67, 2016
- Démurger F et al: New insights into genotype-phenotype correlation for GLI3 mutations. Eur J Hum Genet. 23(1):92-102, 2015
- Li CD et al: Classification of hypothalamic hamartoma and prognostic factors for surgical outcome. Acta Neurol Scand. 130(1):18-26, 2014
- Alves C et al: Giant hypothalamic hamartoma: case report and literature review. Childs Nerv Syst. 29(3):513-6, 2013
- Mittal S et al: Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics. Neurosurg Focus. 34(6):E6, 2013
- Pati S et al: Diagnosis and management of epilepsy associated with hypothalamic hamartoma: an evidence-based systematic review. J Child Neurol. 28(7):909-16, 2013
- Parvizi J et al: Gelastic epilepsy and hypothalamic hamartomas: neuroanatomical analysis of brain lesions in 100 patients. Brain. 134(Pt 10):2960-8, 2011
- Beggs J et al: Hypothalamic hamartomas associated with epilepsy: ultrastructural features. J Neuropathol Exp Neurol. 67(7):657-68, 2008
- Castro LH et al: Epilepsy syndromes associated with hypothalamic hamartomas. Seizure. 16(1):50-8, 2007
- Coons SW et al: The histopathology of hypothalamic hamartomas: study of 57 cases. J Neuropathol Exp Neurol. 66(2):131-41, 2007
- Amstutz DR et al: Hypothalamic hamartomas: correlation of MR imaging and spectroscopic findings with tumor glial content. AJNR Am J Neuroradiol. 27(4):794-8, 2006
- Trivin C et al: Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol (Oxf). 65(2):239-45, 2006
- Boudreau EA et al: Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome cases. Epilepsia. 46(1):42-7, 2005
- Yamura M et al: Evaluation of small hypothalamic hamartomas with 3D constructive interference in steady state (CISS) sequence. Neuroradiology. 47(3):204-8, 2005
- Freeman JL et al: MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol. 25(3):450-62, 2004
- Debeneix C et al: Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images. Horm Res. 56(1-2):12-8, 2001
- Boyko OB et al: Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol. 12(2):309-14, 1991
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Hypothalamic hamartoma (HH), diencephalic hamartoma
Definitions
- Nonneoplastic congenital gray matter heterotopia in region of tuber cinereum
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Du VX et al: Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma? Epilepsia. 58 Suppl 2:77-84, 2017
- Harrison VS et al: Hypothalamic hamartoma with epilepsy: review of endocrine comorbidity. Epilepsia. 58 Suppl 2:50-9, 2017
- Scholly J et al: Hypothalamic hamartoma: epileptogenesis beyond the lesion? Epilepsia. 58 Suppl 2:32-40, 2017
- Rolston JD et al: Stereotactic laser ablation for hypothalamic hamartoma. Neurosurg Clin N Am. 27(1):59-67, 2016
- Démurger F et al: New insights into genotype-phenotype correlation for GLI3 mutations. Eur J Hum Genet. 23(1):92-102, 2015
- Li CD et al: Classification of hypothalamic hamartoma and prognostic factors for surgical outcome. Acta Neurol Scand. 130(1):18-26, 2014
- Alves C et al: Giant hypothalamic hamartoma: case report and literature review. Childs Nerv Syst. 29(3):513-6, 2013
- Mittal S et al: Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics. Neurosurg Focus. 34(6):E6, 2013
- Pati S et al: Diagnosis and management of epilepsy associated with hypothalamic hamartoma: an evidence-based systematic review. J Child Neurol. 28(7):909-16, 2013
- Parvizi J et al: Gelastic epilepsy and hypothalamic hamartomas: neuroanatomical analysis of brain lesions in 100 patients. Brain. 134(Pt 10):2960-8, 2011
- Beggs J et al: Hypothalamic hamartomas associated with epilepsy: ultrastructural features. J Neuropathol Exp Neurol. 67(7):657-68, 2008
- Castro LH et al: Epilepsy syndromes associated with hypothalamic hamartomas. Seizure. 16(1):50-8, 2007
- Coons SW et al: The histopathology of hypothalamic hamartomas: study of 57 cases. J Neuropathol Exp Neurol. 66(2):131-41, 2007
- Amstutz DR et al: Hypothalamic hamartomas: correlation of MR imaging and spectroscopic findings with tumor glial content. AJNR Am J Neuroradiol. 27(4):794-8, 2006
- Trivin C et al: Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol (Oxf). 65(2):239-45, 2006
- Boudreau EA et al: Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome cases. Epilepsia. 46(1):42-7, 2005
- Yamura M et al: Evaluation of small hypothalamic hamartomas with 3D constructive interference in steady state (CISS) sequence. Neuroradiology. 47(3):204-8, 2005
- Freeman JL et al: MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol. 25(3):450-62, 2004
- Debeneix C et al: Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images. Horm Res. 56(1-2):12-8, 2001
- Boyko OB et al: Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol. 12(2):309-14, 1991
