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Idiopathic Infantile Arterial Calcification
Anne M. Kennedy, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Idiopathic infantile arterial calcification (IIAC)
                  • Part of clinical spectrum of ectopic calcification with multiorgan pathology
                  • Considerable overlap in genotype/phenotype of IIAC and pseudoxanthoma elasticum (PXE)
              • Synonyms

                • Generalized arterial calcification of infancy

              IMAGING

              • General Features

                • Ultrasonographic Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                Selected References

                                1. Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
                                2. Karthikeyan G: Generalized arterial calcification of infancy. J Pediatr. 162(5):1074.e1, 2013
                                3. Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
                                4. Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
                                5. Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
                                6. Ryerson LM et al: Two cases of idiopathic infantile arterial calcification. J Paediatr Child Health. 46(12):777-9, 2010
                                7. Nasrallah FK et al: Prenatal diagnosis of idiopathic infantile arterial calcification with hydrops fetalis. Ultrasound Obstet Gynecol. 34(5):601-4, 2009
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Idiopathic infantile arterial calcification (IIAC)
                                                • Part of clinical spectrum of ectopic calcification with multiorgan pathology
                                                • Considerable overlap in genotype/phenotype of IIAC and pseudoxanthoma elasticum (PXE)
                                            • Synonyms

                                              • Generalized arterial calcification of infancy

                                            IMAGING

                                            • General Features

                                              • Ultrasonographic Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Gross Pathologic & Surgical Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
                                                              2. Karthikeyan G: Generalized arterial calcification of infancy. J Pediatr. 162(5):1074.e1, 2013
                                                              3. Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
                                                              4. Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
                                                              5. Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
                                                              6. Ryerson LM et al: Two cases of idiopathic infantile arterial calcification. J Paediatr Child Health. 46(12):777-9, 2010
                                                              7. Nasrallah FK et al: Prenatal diagnosis of idiopathic infantile arterial calcification with hydrops fetalis. Ultrasound Obstet Gynecol. 34(5):601-4, 2009