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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Idiopathic infantile arterial calcification (IIAC)
Synonyms
- Generalized arterial calcification of infancy
Definitions
- Part of clinical spectrum of ectopic calcification with multiorgan pathology
- Considerable overlap with
- Pseudoxanthoma elasticum (PXE)
- Autosomal recessive hypophosphatemic rickets
IMAGING
General Features
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Boyce AM et al: Generalized arterial calcification of infancy: new insights, controversies, and approach to management. Curr Osteoporos Rep. 18(3):232-41, 2020
- Dursun F et al: Magnesium and anti-phosphate treatment with bisphosphonates for generalised arterial calcification of infancy: a case report J Clin Res Pediatr Endocrinol. 11(3):311-8, 2019
- Akhtar Ali S et al: Bisphosphonate therapy in an infant with generalized arterial calcification with an ABCC6 mutation. Osteoporos Int. 29(11):2575-9, 2018
- Khan T et al: ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy. Dis Model Mech. 11(10), 2018
- Yi Y et al: Prenatal diagnosis of idiopathic infantile arterial calcification without fetal hydrops. Echocardiography. 34(2):311-4, 2017
- Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
- Karthikeyan G: Generalized arterial calcification of infancy. J Pediatr. 162(5):1074.e1, 2013
- Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
- Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
- Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Idiopathic infantile arterial calcification (IIAC)
Synonyms
- Generalized arterial calcification of infancy
Definitions
- Part of clinical spectrum of ectopic calcification with multiorgan pathology
- Considerable overlap with
- Pseudoxanthoma elasticum (PXE)
- Autosomal recessive hypophosphatemic rickets
IMAGING
General Features
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Boyce AM et al: Generalized arterial calcification of infancy: new insights, controversies, and approach to management. Curr Osteoporos Rep. 18(3):232-41, 2020
- Dursun F et al: Magnesium and anti-phosphate treatment with bisphosphonates for generalised arterial calcification of infancy: a case report J Clin Res Pediatr Endocrinol. 11(3):311-8, 2019
- Akhtar Ali S et al: Bisphosphonate therapy in an infant with generalized arterial calcification with an ABCC6 mutation. Osteoporos Int. 29(11):2575-9, 2018
- Khan T et al: ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy. Dis Model Mech. 11(10), 2018
- Yi Y et al: Prenatal diagnosis of idiopathic infantile arterial calcification without fetal hydrops. Echocardiography. 34(2):311-4, 2017
- Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
- Karthikeyan G: Generalized arterial calcification of infancy. J Pediatr. 162(5):1074.e1, 2013
- Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
- Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
- Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
