Part of clinical spectrum of ectopic calcification with multiorgan pathology
Considerable overlap with
Pseudoxanthoma elasticum (PXE)
Autosomal recessive hypophosphatemic rickets
IMAGING
General Features
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Boyce AM et al: Generalized arterial calcification of infancy: new insights, controversies, and approach to management. Curr Osteoporos Rep. 18(3):232-41, 2020
Dursun F et al: Magnesium and anti-phosphate treatment with bisphosphonates for generalised arterial calcification of infancy: a case report J Clin Res Pediatr Endocrinol. 11(3):311-8, 2019
Akhtar Ali S et al: Bisphosphonate therapy in an infant with generalized arterial calcification with an ABCC6 mutation. Osteoporos Int. 29(11):2575-9, 2018
Khan T et al: ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy. Dis Model Mech. 11(10), 2018
Yi Y et al: Prenatal diagnosis of idiopathic infantile arterial calcification without fetal hydrops. Echocardiography. 34(2):311-4, 2017
Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
Part of clinical spectrum of ectopic calcification with multiorgan pathology
Considerable overlap with
Pseudoxanthoma elasticum (PXE)
Autosomal recessive hypophosphatemic rickets
IMAGING
General Features
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Boyce AM et al: Generalized arterial calcification of infancy: new insights, controversies, and approach to management. Curr Osteoporos Rep. 18(3):232-41, 2020
Dursun F et al: Magnesium and anti-phosphate treatment with bisphosphonates for generalised arterial calcification of infancy: a case report J Clin Res Pediatr Endocrinol. 11(3):311-8, 2019
Akhtar Ali S et al: Bisphosphonate therapy in an infant with generalized arterial calcification with an ABCC6 mutation. Osteoporos Int. 29(11):2575-9, 2018
Khan T et al: ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy. Dis Model Mech. 11(10), 2018
Yi Y et al: Prenatal diagnosis of idiopathic infantile arterial calcification without fetal hydrops. Echocardiography. 34(2):311-4, 2017
Li Q et al: Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum. J Invest Dermatol. 134(3):658-65, 2014
Iglesias-Platas I et al: Two new cases of idiopathic arterial calcification in the newborn: watch out for lineal calcifications in plain radiographs. J Pediatr. 161(4):767-767.e1, 2012
Cansu A et al: Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation. Clin Exp Obstet Gynecol. 37(1):73-5, 2010
Heuser CC et al: Radiographic and pathologic evaluation of idiopathic infantile arterial calcification. Obstet Gynecol. 115(2 Pt 2):465-8, 2010
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