Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Idiopathic orbital inflammation (IOI)
Synonyms
- Orbital pseudotumor (or simply "pseudotumor")
Definitions
- Nonspecific orbital inflammation, often without known etiology or systemic illness
- Tolosa-Hunt syndrome
- Variant apical form extending into cavernous sinus
- Sclerosing orbital inflammatory pseudotumor
- Variant form with chronic progressive fibrosis
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Ronquillo Y et al: Nonspecific orbital inflammation. StatPeals, 2021
- Eissa L et al: Arterial spin labeling and diffusion-weighted MR imaging: utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma. Clin Imaging. 71:63-8, 2020
- Madhavan AA et al: Bilateral facial nerve involvement in a patient with Tolosa-Hunt syndrome. Neuroradiol J. 33(5):424-7, 2020
- Marinò M et al: Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis. J Endocrinol Invest. 43(4):401-11, 2020
- Wu WC et al: Clinical images: IgG4-related orbital pseudotumor. Arthritis Rheumatol. 72(12):2168, 2020
- Ferreira TA et al: CT and MR imaging of orbital inflammation. Neuroradiology. 60(12):1253-66, 2018
- Guo J et al: MR-based radiomics signature in differentiating ocular adnexal lymphoma from idiopathic orbital inflammation. Eur Radiol. 28(9):3872-81, 2018
- Ren J et al: Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. BMC Med Imaging. 18(1):6, 2018
- Cunnane MB et al: Imaging of orbital disorders. Handb Clin Neurol. 135:659-72, 2016
- McNab AA et al: IgG4-related ophthalmic disease. part ii: clinical aspects. Ophthal Plast Reconstr Surg. 31(3):167-78, 2015
- Bijlsma WR et al: Risk factors for idiopathic orbital inflammation: a case-control study. Br J Ophthalmol. 95(3):360-4, 2011
- Mendenhall WM et al: Orbital pseudotumor. Am J Clin Oncol. 33(3):304-6, 2010
- Schuknecht B et al: Tolosa-Hunt syndrome: MR imaging features in 15 patients with 20 episodes of painful ophthalmoplegia. Eur J Radiol. 69(3):445-53, 2009
- Katsimpris JM et al: Isolated lateral rectus myositis as a manifestation of idiopathic orbital inflammation. Klin Monbl Augenheilkd. 225(5):510-3, 2008
- Swamy BN et al: Idiopathic orbital inflammatory syndrome: clinical features and treatment outcomes. Br J Ophthalmol. 91(12):1667-70, 2007
- Brannan PA et al: Sclerosing idiopathic orbital inflammation. J Pediatr Ophthalmol Strabismus. 43(3):183-4, 2006
- Gordon LK: Diagnostic dilemmas in orbital inflammatory disease. Ocul Immunol Inflamm. 11(1):3-15, 2003
- Yuen SJ et al: Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol. 121(4):491-9, 2003
- Jacobs D et al: Diagnosis and management of orbital pseudotumor. Curr Opin Ophthalmol. 13(6):347-51, 2002
- Wasmeier C et al: Idiopathic inflammatory pseudotumor of the orbit and Tolosa-Hunt syndrome--are they the same disease? J Neurol. 249(9):1237-41, 2002
- Yuen SJ et al: Idiopathic orbital inflammation: ocular mechanisms and clinicopathology. Ophthalmol Clin North Am. 15(1):121-6, 2002
- Bernardino CR et al: Angle-closure glaucoma in association with orbital pseudotumor. Ophthalmology. 108(9):1603-6, 2001
- Maalouf T et al: What has become of our idiopathic inflammatory pseudo-tumors of the orbit? Orbit. 18(3):157-66, 1999
- Weber AL et al: Pseudotumor of the orbit. Clinical, pathologic, and radiologic evaluation. Radiol Clin North Am. 37(1):151-68, xi, 1999
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Idiopathic orbital inflammation (IOI)
Synonyms
- Orbital pseudotumor (or simply "pseudotumor")
Definitions
- Nonspecific orbital inflammation, often without known etiology or systemic illness
- Tolosa-Hunt syndrome
- Variant apical form extending into cavernous sinus
- Sclerosing orbital inflammatory pseudotumor
- Variant form with chronic progressive fibrosis
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Ronquillo Y et al: Nonspecific orbital inflammation. StatPeals, 2021
- Eissa L et al: Arterial spin labeling and diffusion-weighted MR imaging: utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma. Clin Imaging. 71:63-8, 2020
- Madhavan AA et al: Bilateral facial nerve involvement in a patient with Tolosa-Hunt syndrome. Neuroradiol J. 33(5):424-7, 2020
- Marinò M et al: Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis. J Endocrinol Invest. 43(4):401-11, 2020
- Wu WC et al: Clinical images: IgG4-related orbital pseudotumor. Arthritis Rheumatol. 72(12):2168, 2020
- Ferreira TA et al: CT and MR imaging of orbital inflammation. Neuroradiology. 60(12):1253-66, 2018
- Guo J et al: MR-based radiomics signature in differentiating ocular adnexal lymphoma from idiopathic orbital inflammation. Eur Radiol. 28(9):3872-81, 2018
- Ren J et al: Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps. BMC Med Imaging. 18(1):6, 2018
- Cunnane MB et al: Imaging of orbital disorders. Handb Clin Neurol. 135:659-72, 2016
- McNab AA et al: IgG4-related ophthalmic disease. part ii: clinical aspects. Ophthal Plast Reconstr Surg. 31(3):167-78, 2015
- Bijlsma WR et al: Risk factors for idiopathic orbital inflammation: a case-control study. Br J Ophthalmol. 95(3):360-4, 2011
- Mendenhall WM et al: Orbital pseudotumor. Am J Clin Oncol. 33(3):304-6, 2010
- Schuknecht B et al: Tolosa-Hunt syndrome: MR imaging features in 15 patients with 20 episodes of painful ophthalmoplegia. Eur J Radiol. 69(3):445-53, 2009
- Katsimpris JM et al: Isolated lateral rectus myositis as a manifestation of idiopathic orbital inflammation. Klin Monbl Augenheilkd. 225(5):510-3, 2008
- Swamy BN et al: Idiopathic orbital inflammatory syndrome: clinical features and treatment outcomes. Br J Ophthalmol. 91(12):1667-70, 2007
- Brannan PA et al: Sclerosing idiopathic orbital inflammation. J Pediatr Ophthalmol Strabismus. 43(3):183-4, 2006
- Gordon LK: Diagnostic dilemmas in orbital inflammatory disease. Ocul Immunol Inflamm. 11(1):3-15, 2003
- Yuen SJ et al: Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol. 121(4):491-9, 2003
- Jacobs D et al: Diagnosis and management of orbital pseudotumor. Curr Opin Ophthalmol. 13(6):347-51, 2002
- Wasmeier C et al: Idiopathic inflammatory pseudotumor of the orbit and Tolosa-Hunt syndrome--are they the same disease? J Neurol. 249(9):1237-41, 2002
- Yuen SJ et al: Idiopathic orbital inflammation: ocular mechanisms and clinicopathology. Ophthalmol Clin North Am. 15(1):121-6, 2002
- Bernardino CR et al: Angle-closure glaucoma in association with orbital pseudotumor. Ophthalmology. 108(9):1603-6, 2001
- Maalouf T et al: What has become of our idiopathic inflammatory pseudo-tumors of the orbit? Orbit. 18(3):157-66, 1999
- Weber AL et al: Pseudotumor of the orbit. Clinical, pathologic, and radiologic evaluation. Radiol Clin North Am. 37(1):151-68, xi, 1999
