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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- IgG4-related disease (IgG4-RD)
Synonyms
- Previously recognized head and neck conditions now acknowledged to fall within spectrum of IgG4-RD
- Mikulicz syndrome
- Küttner tumor
- Riedel thyroiditis
- Inflammatory pseudotumor
- Eosinophilic angiocentric fibrosis
- Previously recognized head and neck conditions now acknowledged to fall within spectrum of IgG4-RD
Definitions
- Recently recognized idiopathic systemic fibroinflammatory condition characterized by tendency to form tumor-like lesion with dense lymphoplasmacytic infiltrate rich in IgG4-positive cells
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
Immunohistochemical Features
Serum IgG4 Level
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Thompson A et al: Imaging of IgG4-related disease of the head and neck. Clin Radiol. ePub, 2017
- Mulholland GB et al: Immunoglobulin G4-related diseases in the head and neck: a systematic review. J Otolaryngol Head Neck Surg. 44:24, 2015
- Ferry JA et al: IgG4-related disease in the head and neck. Semin Diagn Pathol. 29(4):235-44, 2012
- Fujita A et al: IgG4-related disease of the head and neck: CT and MR imaging manifestations. Radiographics. 32(7):1945-58, 2012
- Inoue D et al: IgG4-related perineural disease. Int J Rheumatol. 2012:401890, 2012
- Stone JH et al: Mechanisms of disease: IgG4-related disease. N Engl J Med. 36:539–51, 2012
- Stone JH: IgG4-related disease: nomenclature, clinical features, and treatment. Semin Diagn Pathol. 29(4):177-90, 2012
- Toyoda K et al: MR imaging of IgG4-related disease in the head and neck and brain. AJNR Am J Neuroradiol. 33(11):2136-9, 2012
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- IgG4-related disease (IgG4-RD)
Synonyms
- Previously recognized head and neck conditions now acknowledged to fall within spectrum of IgG4-RD
- Mikulicz syndrome
- Küttner tumor
- Riedel thyroiditis
- Inflammatory pseudotumor
- Eosinophilic angiocentric fibrosis
- Previously recognized head and neck conditions now acknowledged to fall within spectrum of IgG4-RD
Definitions
- Recently recognized idiopathic systemic fibroinflammatory condition characterized by tendency to form tumor-like lesion with dense lymphoplasmacytic infiltrate rich in IgG4-positive cells
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
Immunohistochemical Features
Serum IgG4 Level
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Thompson A et al: Imaging of IgG4-related disease of the head and neck. Clin Radiol. ePub, 2017
- Mulholland GB et al: Immunoglobulin G4-related diseases in the head and neck: a systematic review. J Otolaryngol Head Neck Surg. 44:24, 2015
- Ferry JA et al: IgG4-related disease in the head and neck. Semin Diagn Pathol. 29(4):235-44, 2012
- Fujita A et al: IgG4-related disease of the head and neck: CT and MR imaging manifestations. Radiographics. 32(7):1945-58, 2012
- Inoue D et al: IgG4-related perineural disease. Int J Rheumatol. 2012:401890, 2012
- Stone JH et al: Mechanisms of disease: IgG4-related disease. N Engl J Med. 36:539–51, 2012
- Stone JH: IgG4-related disease: nomenclature, clinical features, and treatment. Semin Diagn Pathol. 29(4):177-90, 2012
- Toyoda K et al: MR imaging of IgG4-related disease in the head and neck and brain. AJNR Am J Neuroradiol. 33(11):2136-9, 2012
