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Head and Neck
Differential Diagnosis
Orbit
Generic Imaging Patterns
Ill-Defined Orbital Mass
Ill-Defined Orbital Mass
Kristine M. Mosier, DMD, PhD
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DIFFERENTIAL DIAGNOSIS

    ESSENTIAL INFORMATION

    • Helpful Clues for Common Diagnoses

      • Helpful Clues for Less Common Diagnoses

        • Helpful Clues for Rare Diagnoses

          Selected References

          1. Andron A et al: The impact of IgG-4-ROD on the diagnosis of orbital tumors: a retrospective analysis. Orbit. 36(6):359-364, 2017
          2. Derzko-Dzulynsky L: IgG4-related disease in the eye and ocular adnexa. Curr Opin Ophthalmol. 28(6):617-622, 2017
          3. Hersh D et al: Idiopathic Orbital Inflammatory Disease. In: Mukherjee B et al: Emergencies of the Orbit and Adnexa. New Delhi: Springer, 2017
          4. Homer N et al: Periocular breast carcinoma metastases: correlation of clinical, radiologic and histopathologic features. Clin Exp Ophthalmol. 45(6):606-612, 2017
          5. McKelvie P et al: Comparative study of clinical, pathological, radiological, and genetic features of patients with adult ocular adnexal xanthogranulomatous disease, Erdheim-Chester disease, and IgG4-related disease of the orbit/ocular adnexa. Ophthal Plast Reconstr Surg. 33(2):112-119, 2017
          6. Khandji J et al: IgG4-related orbital disease masquerading as thyroid eye disease, vice versa, or both? Orbit. 1-4, 2017
          7. Park J et al: Risk factors for extraophthalmic involvement and treatment outcomes in patients with IgG4-related ophthalmic disease. Br J Ophthalmol. ePub, 2017
          8. Smerla RG et al: Ocular manifestations of IgG4-related disease in children. more common than anticipated? review of the literature and case report. Clin Rheumatol. ePub, 2017
          9. Soussan JB et al: Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign. Eur Radiol. 27(4):1335-1343, 2017
          10. Lee KH et al: Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease. Br J Ophthalmol. 100(9):1295-300, 2016
          11. Purohit BS et al: Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging. Insights Imaging. 7(1):43-68, 2016
          12. Brucker JL et al: Imaging of head and neck emergencies. Radiol Clin North Am. 53(1):215-52, 2015
          13. Dankbaar JW et al: Imaging findings of the orbital and intracranial complications of acute bacterial rhinosinusitis. Insights Imaging. 6(5):509-18, 2015
          14. Griauzde J et al: Imaging of vascular lesions of the head and neck. Radiol Clin North Am. 53(1):197-213, 2015
          15. Mulay K and Honavar SG. Idiopathic (non-specific) orbital inflammation. Diag Histopath. 21(1):34-47, 2015
          16. Rosenbaum JT et al: Molecular diagnosis of orbital inflammatory disease. Exp Mol Pathol. 98(2):225-9, 2015
          17. Vachha BA et al: Imaging of pediatric orbital diseases. Neuroimaging Clin N Am. 25(3):477-501, 2015
          18. Haradome K et al: Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. AJNR Am J Neuroradiol. 35(10):1976-82, 2014
          19. Le TD et al: The effect of adding orbital computed tomography findings to the Chandler criteria for classifying pediatric orbital cellulitis in predicting which patients will require surgical intervention. J AAPOS. 18(3):271-7, 2014
          20. Rootman J et al: Vascular malformations of the orbit: classification and the role of imaging in diagnosis and treatment strategies*. Ophthal Plast Reconstr Surg. 30(2):91-104, 2014
          21. Nwawka OK et al: Granulomatous disease in the head and neck: developing a differential diagnosis. Radiographics. 34(5):1240-56, 2014
          22. Beylergil V et al: Visualization of orbital involvement of Erdheim-Chester disease on PET/CT. Clin Nucl Med. 39(7):660-1, 2014
          23. Wong AJ et al: IgG4 immunostaining and its implications in orbital inflammatory disease. PLoS One. 9(10):e109847, 2014
          24. Deshpande V et al: Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 25(9):1181-92, 2012
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          References
          Tables

          Tables

          DIFFERENTIAL DIAGNOSIS

            ESSENTIAL INFORMATION

            • Helpful Clues for Common Diagnoses

              • Helpful Clues for Less Common Diagnoses

                • Helpful Clues for Rare Diagnoses

                  Selected References

                  1. Andron A et al: The impact of IgG-4-ROD on the diagnosis of orbital tumors: a retrospective analysis. Orbit. 36(6):359-364, 2017
                  2. Derzko-Dzulynsky L: IgG4-related disease in the eye and ocular adnexa. Curr Opin Ophthalmol. 28(6):617-622, 2017
                  3. Hersh D et al: Idiopathic Orbital Inflammatory Disease. In: Mukherjee B et al: Emergencies of the Orbit and Adnexa. New Delhi: Springer, 2017
                  4. Homer N et al: Periocular breast carcinoma metastases: correlation of clinical, radiologic and histopathologic features. Clin Exp Ophthalmol. 45(6):606-612, 2017
                  5. McKelvie P et al: Comparative study of clinical, pathological, radiological, and genetic features of patients with adult ocular adnexal xanthogranulomatous disease, Erdheim-Chester disease, and IgG4-related disease of the orbit/ocular adnexa. Ophthal Plast Reconstr Surg. 33(2):112-119, 2017
                  6. Khandji J et al: IgG4-related orbital disease masquerading as thyroid eye disease, vice versa, or both? Orbit. 1-4, 2017
                  7. Park J et al: Risk factors for extraophthalmic involvement and treatment outcomes in patients with IgG4-related ophthalmic disease. Br J Ophthalmol. ePub, 2017
                  8. Smerla RG et al: Ocular manifestations of IgG4-related disease in children. more common than anticipated? review of the literature and case report. Clin Rheumatol. ePub, 2017
                  9. Soussan JB et al: Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign. Eur Radiol. 27(4):1335-1343, 2017
                  10. Lee KH et al: Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease. Br J Ophthalmol. 100(9):1295-300, 2016
                  11. Purohit BS et al: Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging. Insights Imaging. 7(1):43-68, 2016
                  12. Brucker JL et al: Imaging of head and neck emergencies. Radiol Clin North Am. 53(1):215-52, 2015
                  13. Dankbaar JW et al: Imaging findings of the orbital and intracranial complications of acute bacterial rhinosinusitis. Insights Imaging. 6(5):509-18, 2015
                  14. Griauzde J et al: Imaging of vascular lesions of the head and neck. Radiol Clin North Am. 53(1):197-213, 2015
                  15. Mulay K and Honavar SG. Idiopathic (non-specific) orbital inflammation. Diag Histopath. 21(1):34-47, 2015
                  16. Rosenbaum JT et al: Molecular diagnosis of orbital inflammatory disease. Exp Mol Pathol. 98(2):225-9, 2015
                  17. Vachha BA et al: Imaging of pediatric orbital diseases. Neuroimaging Clin N Am. 25(3):477-501, 2015
                  18. Haradome K et al: Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs. AJNR Am J Neuroradiol. 35(10):1976-82, 2014
                  19. Le TD et al: The effect of adding orbital computed tomography findings to the Chandler criteria for classifying pediatric orbital cellulitis in predicting which patients will require surgical intervention. J AAPOS. 18(3):271-7, 2014
                  20. Rootman J et al: Vascular malformations of the orbit: classification and the role of imaging in diagnosis and treatment strategies*. Ophthal Plast Reconstr Surg. 30(2):91-104, 2014
                  21. Nwawka OK et al: Granulomatous disease in the head and neck: developing a differential diagnosis. Radiographics. 34(5):1240-56, 2014
                  22. Beylergil V et al: Visualization of orbital involvement of Erdheim-Chester disease on PET/CT. Clin Nucl Med. 39(7):660-1, 2014
                  23. Wong AJ et al: IgG4 immunostaining and its implications in orbital inflammatory disease. PLoS One. 9(10):e109847, 2014
                  24. Deshpande V et al: Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 25(9):1181-92, 2012