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Immunodeficiency-Associated CNS Lymphoma
Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Lymphomas associated with inherited or acquired immunodeficiency
              • Includes AIDS-related diffuse large B-cell lymphoma (A-DLBCL), Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV-DLBCL) of elderly, lymphomatoid granulomatosis (LG), and CNS posttransplant lymphoproliferative disorders (CNS-PTLD)

            IMAGING

            • General Features

              • A-DLBCL

                • EBV-DLBCL

                  • LG

                    • CNS-PTLD

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. He C et al: Isolated lymphomatoid granulomatosis of the central nervous system: a case report and literature review. Neuropathology. 39(6):479-88, 2019
                                          2. Kaulen LD et al: Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma. J Neurooncol. 144(1):107-15, 2019
                                          3. Lilly AJ et al: Human immunodeficiency virus-associated lymphoproliferative disorders. Surg Pathol Clin. 12(3):771-82, 2019
                                          4. Vangipuram R et al: AIDS-associated malignancies. Cancer Treat Res. 177:1-21, 2019
                                          5. White ML et al: Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential. Insights Imaging. 10(1):46, 2019
                                          6. Castillo JJ et al: EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 93(7):953-62, 2018
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Lymphomas associated with inherited or acquired immunodeficiency
                                                      • Includes AIDS-related diffuse large B-cell lymphoma (A-DLBCL), Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV-DLBCL) of elderly, lymphomatoid granulomatosis (LG), and CNS posttransplant lymphoproliferative disorders (CNS-PTLD)

                                                    IMAGING

                                                    • General Features

                                                      • A-DLBCL

                                                        • EBV-DLBCL

                                                          • LG

                                                            • CNS-PTLD

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. He C et al: Isolated lymphomatoid granulomatosis of the central nervous system: a case report and literature review. Neuropathology. 39(6):479-88, 2019
                                                                                  2. Kaulen LD et al: Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma. J Neurooncol. 144(1):107-15, 2019
                                                                                  3. Lilly AJ et al: Human immunodeficiency virus-associated lymphoproliferative disorders. Surg Pathol Clin. 12(3):771-82, 2019
                                                                                  4. Vangipuram R et al: AIDS-associated malignancies. Cancer Treat Res. 177:1-21, 2019
                                                                                  5. White ML et al: Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential. Insights Imaging. 10(1):46, 2019
                                                                                  6. Castillo JJ et al: EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 93(7):953-62, 2018