Infantile myofibroma: Solitary, benign fibrous tumor of young children with high rate of spontaneous regression
Myofibromatosis: Multifocal disease
Multicentric without visceral involvement: Soft tissue &/or bone lesions
Multicentric with visceral involvement (or generalized): Additional organ systems are involved with poorer prognosis
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Manisterski M et al: Diverse presentation and tailored treatment of infantile myofibromatosis: a single-center experience. Pediatr Blood Cancer. 68(2):e28769, 2021
Naffaa L et al: Infantile myofibromatosis: review of imaging findings and emphasis on correlation between MRI and histopathological findings. Clin Imaging. 54:40-7, 2019
Pekar-Zlotin M et al: Honeycomb appearance of fetal myofibromatosis. Ultrasound Obstet Gynecol. 53(4):549-51, 2019
Rekawek P et al: Prenatal sonography of multicentric infantile myofibromatosis: case report and review of the literature. J Clin Ultrasound. 47(8):490-3, 2019
Murray N et al: The spectrum of infantile myofibromatosis includes both non-penetrance and adult recurrence. Eur J Med Genet. 60(7):353-8, 2017
Tang ER et al: Utility of 18F-FDG PET/CT in infantile myofibromatosis. Clin Nucl Med. 44(8):676-9, 2019
Ushida T et al: A large mediastinal tumour invading into the liver with foetal hydrops: a rare case of infantile myofibromatosis. J Obstet Gynaecol. 37(6):821-3, 2017
Salerno S et al: Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: a case report. Mol Clin Oncol. 6(4):579-82, 2017
Sargar KM et al: Pediatric fibroblastic and myofibroblastic tumors: a pictorial review. Radiographics. 36(4):1195-214, 2016
Coleman AM et al: Prenatal diagnosis of infantile myofibroma with postnatal imaging correlation. Fetal Diagn Ther. 40(1):73-8, 2016
Wu SY et al: Chemotherapy for generalized infantile myofibromatosis with visceral involvement. J Pediatr Hematol Oncol. 37(5):402-5, 2015
Mashiah J et al: Infantile myofibromatosis: a series of 28 cases. J Am Acad Dermatol. 71(2):264-70, 2014
Martignetti JA et al: Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 92(6):1001-7, 2013
Holzer-Fruehwald L et al: Imaging findings in seven cases of congenital infantile myofibromatosis with cerebral, spinal, or head and neck involvement. Neuroradiology. 54(12):1389-98, 2012
Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
Koujok K et al: Myofibromatosis: imaging characteristics. Pediatr Radiol. 35(4):374-80, 2005
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Definitions
Infantile myofibroma: Solitary, benign fibrous tumor of young children with high rate of spontaneous regression
Myofibromatosis: Multifocal disease
Multicentric without visceral involvement: Soft tissue &/or bone lesions
Multicentric with visceral involvement (or generalized): Additional organ systems are involved with poorer prognosis
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Manisterski M et al: Diverse presentation and tailored treatment of infantile myofibromatosis: a single-center experience. Pediatr Blood Cancer. 68(2):e28769, 2021
Naffaa L et al: Infantile myofibromatosis: review of imaging findings and emphasis on correlation between MRI and histopathological findings. Clin Imaging. 54:40-7, 2019
Pekar-Zlotin M et al: Honeycomb appearance of fetal myofibromatosis. Ultrasound Obstet Gynecol. 53(4):549-51, 2019
Rekawek P et al: Prenatal sonography of multicentric infantile myofibromatosis: case report and review of the literature. J Clin Ultrasound. 47(8):490-3, 2019
Murray N et al: The spectrum of infantile myofibromatosis includes both non-penetrance and adult recurrence. Eur J Med Genet. 60(7):353-8, 2017
Tang ER et al: Utility of 18F-FDG PET/CT in infantile myofibromatosis. Clin Nucl Med. 44(8):676-9, 2019
Ushida T et al: A large mediastinal tumour invading into the liver with foetal hydrops: a rare case of infantile myofibromatosis. J Obstet Gynaecol. 37(6):821-3, 2017
Salerno S et al: Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: a case report. Mol Clin Oncol. 6(4):579-82, 2017
Sargar KM et al: Pediatric fibroblastic and myofibroblastic tumors: a pictorial review. Radiographics. 36(4):1195-214, 2016
Coleman AM et al: Prenatal diagnosis of infantile myofibroma with postnatal imaging correlation. Fetal Diagn Ther. 40(1):73-8, 2016
Wu SY et al: Chemotherapy for generalized infantile myofibromatosis with visceral involvement. J Pediatr Hematol Oncol. 37(5):402-5, 2015
Mashiah J et al: Infantile myofibromatosis: a series of 28 cases. J Am Acad Dermatol. 71(2):264-70, 2014
Martignetti JA et al: Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 92(6):1001-7, 2013
Holzer-Fruehwald L et al: Imaging findings in seven cases of congenital infantile myofibromatosis with cerebral, spinal, or head and neck involvement. Neuroradiology. 54(12):1389-98, 2012
Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
Koujok K et al: Myofibromatosis: imaging characteristics. Pediatr Radiol. 35(4):374-80, 2005
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