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Infantile Myofibroma/Myofibromatosis
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Congenital generalized fibromatosis
          • Definitions

            • Infantile myofibroma: Solitary benign fibrous tumor of young children with high rate of spontaneous regression
            • Myofibromatosis: Multifocal disease
              • Multicentric without visceral involvement: Soft tissue &/or bone lesions
              • Multicentric with visceral involvement (or generalized): Additional organ systems involved, poorer prognosis

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Coleman AM et al: Prenatal diagnosis of infantile myofibroma with postnatal imaging correlation. Fetal Diagn Ther. 40(1):73-8, 2016
                                  2. Wu SY et al: Chemotherapy for generalized infantile myofibromatosis with visceral involvement. J Pediatr Hematol Oncol. 37(5):402-5, 2015
                                  3. Mashiah J et al: Infantile myofibromatosis: a series of 28 cases. J Am Acad Dermatol. 71(2):264-70, 2014
                                  4. Martignetti JA et al: Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 92(6):1001-7, 2013
                                  5. Holzer-Fruehwald L et al: Imaging findings in seven cases of congenital infantile myofibromatosis with cerebral, spinal, or head and neck involvement. Neuroradiology. 54(12):1389-98, 2012
                                  6. Levine E et al: Risk-adapted therapy for infantile myofibromatosis in children. Pediatr Blood Cancer. 59(1):115-20, 2012
                                  7. Miwa T et al: Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra. Childs Nerv Syst. 27(3):491-6, 2011
                                  8. Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
                                  9. Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
                                  10. Gopal M et al: Infantile myofibromatosis. Pediatr Surg Int. 24(3):287-91, 2008
                                  11. Koujok K et al: Myofibromatosis: imaging characteristics. Pediatr Radiol. 35(4):374-80, 2005
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Congenital generalized fibromatosis
                                          • Definitions

                                            • Infantile myofibroma: Solitary benign fibrous tumor of young children with high rate of spontaneous regression
                                            • Myofibromatosis: Multifocal disease
                                              • Multicentric without visceral involvement: Soft tissue &/or bone lesions
                                              • Multicentric with visceral involvement (or generalized): Additional organ systems involved, poorer prognosis

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Ultrasonographic Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Coleman AM et al: Prenatal diagnosis of infantile myofibroma with postnatal imaging correlation. Fetal Diagn Ther. 40(1):73-8, 2016
                                                                  2. Wu SY et al: Chemotherapy for generalized infantile myofibromatosis with visceral involvement. J Pediatr Hematol Oncol. 37(5):402-5, 2015
                                                                  3. Mashiah J et al: Infantile myofibromatosis: a series of 28 cases. J Am Acad Dermatol. 71(2):264-70, 2014
                                                                  4. Martignetti JA et al: Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 92(6):1001-7, 2013
                                                                  5. Holzer-Fruehwald L et al: Imaging findings in seven cases of congenital infantile myofibromatosis with cerebral, spinal, or head and neck involvement. Neuroradiology. 54(12):1389-98, 2012
                                                                  6. Levine E et al: Risk-adapted therapy for infantile myofibromatosis in children. Pediatr Blood Cancer. 59(1):115-20, 2012
                                                                  7. Miwa T et al: Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra. Childs Nerv Syst. 27(3):491-6, 2011
                                                                  8. Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
                                                                  9. Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
                                                                  10. Gopal M et al: Infantile myofibromatosis. Pediatr Surg Int. 24(3):287-91, 2008
                                                                  11. Koujok K et al: Myofibromatosis: imaging characteristics. Pediatr Radiol. 35(4):374-80, 2005