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Inflammatory Bowel Disease
Sonia L. Betancourt-Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Inflammatory bowel disease (IBD)
              • Synonyms

                • IBD-associated lung disease
              • Definitions

                • Likely secondary to inappropriate immune response to physiologic gut flora in host with genetic susceptibility
                • Ulcerative colitis (UC) and Crohn disease (CD)
                  • UC: Limited to colon
                  • CD: Any segment of gastrointestinal tract
                • Extraintestinal manifestations of IBD in 16-40% of affected patients; more common in CD
                  • Pulmonary manifestations rare but often overlooked
                    • Secondary to disease itself or complication of drug therapy (e.g., drug toxicity, opportunistic infection)

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Massart A et al: Pulmonary manifestations of inflammatory bowel disease. Am J Med. 133(1):39-43, 2020
                                    2. Myer AS et al: An infrequent extraintestinal manifestation of ulcerative colitis: pulmonary necrobiotic nodules. Cureus. 12(8):e9774, 2020
                                    3. Chams S et al: Inflammatory bowel disease: looking beyond the tract. Int J Immunopathol Pharmacol. 33:2058738419866567, 2019
                                    4. Cozzi D et al: Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018:5697846, 2018
                                    5. Majewski S et al: Pulmonary manifestations of inflammatory bowel disease. Arch Med Sci. 11(6):1179-88, 2015
                                    6. Ji XQ et al: Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol. 20(37):13501-11, 2014
                                    7. Lu DG et al: Pulmonary manifestations of Crohn's disease. World J Gastroenterol. 20(1):133-41, 2014
                                    8. O'Connor RB: Cardiovascular stress testing. J Occup Med. 10(11):672, 1968
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Inflammatory bowel disease (IBD)
                                                • Synonyms

                                                  • IBD-associated lung disease
                                                • Definitions

                                                  • Likely secondary to inappropriate immune response to physiologic gut flora in host with genetic susceptibility
                                                  • Ulcerative colitis (UC) and Crohn disease (CD)
                                                    • UC: Limited to colon
                                                    • CD: Any segment of gastrointestinal tract
                                                  • Extraintestinal manifestations of IBD in 16-40% of affected patients; more common in CD
                                                    • Pulmonary manifestations rare but often overlooked
                                                      • Secondary to disease itself or complication of drug therapy (e.g., drug toxicity, opportunistic infection)

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Massart A et al: Pulmonary manifestations of inflammatory bowel disease. Am J Med. 133(1):39-43, 2020
                                                                      2. Myer AS et al: An infrequent extraintestinal manifestation of ulcerative colitis: pulmonary necrobiotic nodules. Cureus. 12(8):e9774, 2020
                                                                      3. Chams S et al: Inflammatory bowel disease: looking beyond the tract. Int J Immunopathol Pharmacol. 33:2058738419866567, 2019
                                                                      4. Cozzi D et al: Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018:5697846, 2018
                                                                      5. Majewski S et al: Pulmonary manifestations of inflammatory bowel disease. Arch Med Sci. 11(6):1179-88, 2015
                                                                      6. Ji XQ et al: Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol. 20(37):13501-11, 2014
                                                                      7. Lu DG et al: Pulmonary manifestations of Crohn's disease. World J Gastroenterol. 20(1):133-41, 2014
                                                                      8. O'Connor RB: Cardiovascular stress testing. J Occup Med. 10(11):672, 1968