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Inflammatory Bowel Disease
Sonia L. Betancourt Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Inflammatory bowel disease (IBD)
              • Synonyms

                • IBD-associated lung disease
              • Definitions

                • Likely result of inappropriate immune response to physiologic gut flora in host with genetic susceptibility
                • Includes ulcerative colitis (UC) and Crohn disease (CD)
                  • UC: Limited to colon
                  • CD: Any segment of gastrointestinal tract
                • Extraintestinal manifestations of IBD are present in 16-40% of affected patients but are more common in CD
                  • Pulmonary manifestations are rare but often overlooked
                    • May be secondary to disease itself or may occur as complication of drugs used to treat disease (e.g., drug toxicity, opportunistic infection)

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Majewski S et al: Pulmonary manifestations of inflammatory bowel disease. Arch Med Sci. 11(6):1179-88, 2015
                                    2. Ji XQ et al: Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol. 20(37):13501-11, 2014
                                    3. Lu DG et al: Pulmonary manifestations of Crohn's disease. World J Gastroenterol. 20(1):133-41, 2014
                                    4. Ott C et al: Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol. 10(10):585-95, 2013
                                    5. Casella G et al: Pulmonary diseases associated with inflammatory bowel diseases. J Crohns Colitis. 4(4):384-9, 2010
                                    6. D'Andrea N et al: Respiratory involvement in inflammatory bowel diseases. Multidiscip Respir Med. 5(3):173-82, 2010
                                    7. Park JE et al: [Mesalazine-induced eosinophilic pneumonia in a patient with Crohn's disease.] Korean J Gastroenterol. 53(2):116-20, 2009
                                    8. Fries W et al: Association between inflammatory bowel disease and sarcoidosis. Report of two cases and review of the literature. Scand J Gastroenterol. 30(12):1221-3, 1995
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Inflammatory bowel disease (IBD)
                                                • Synonyms

                                                  • IBD-associated lung disease
                                                • Definitions

                                                  • Likely result of inappropriate immune response to physiologic gut flora in host with genetic susceptibility
                                                  • Includes ulcerative colitis (UC) and Crohn disease (CD)
                                                    • UC: Limited to colon
                                                    • CD: Any segment of gastrointestinal tract
                                                  • Extraintestinal manifestations of IBD are present in 16-40% of affected patients but are more common in CD
                                                    • Pulmonary manifestations are rare but often overlooked
                                                      • May be secondary to disease itself or may occur as complication of drugs used to treat disease (e.g., drug toxicity, opportunistic infection)

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Majewski S et al: Pulmonary manifestations of inflammatory bowel disease. Arch Med Sci. 11(6):1179-88, 2015
                                                                      2. Ji XQ et al: Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol. 20(37):13501-11, 2014
                                                                      3. Lu DG et al: Pulmonary manifestations of Crohn's disease. World J Gastroenterol. 20(1):133-41, 2014
                                                                      4. Ott C et al: Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol. 10(10):585-95, 2013
                                                                      5. Casella G et al: Pulmonary diseases associated with inflammatory bowel diseases. J Crohns Colitis. 4(4):384-9, 2010
                                                                      6. D'Andrea N et al: Respiratory involvement in inflammatory bowel diseases. Multidiscip Respir Med. 5(3):173-82, 2010
                                                                      7. Park JE et al: [Mesalazine-induced eosinophilic pneumonia in a patient with Crohn's disease.] Korean J Gastroenterol. 53(2):116-20, 2009
                                                                      8. Fries W et al: Association between inflammatory bowel disease and sarcoidosis. Report of two cases and review of the literature. Scand J Gastroenterol. 30(12):1221-3, 1995