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Inflammatory Myofibroblastic Tumor
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Abbreviations

            • Inflammatory myofibroblastic tumor (IMT)
          • Synonyms

            • Plasma cell granuloma, myofibrohistiocytic proliferation
            • Not inflammatory pseudotumor (nonneoplastic process of unknown etiology)
            • Not idiopathic hypertrophic pachymeningitis
          • Definitions

            • Spindle cell neoplasm of intermediate biological potential with conspicuous inflammatory background
            • Clonal neoplasm with ALK gene rearrangements/translocations in 50-70%

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Han MS et al: Intracranial inflammatory pseudotumor associated with idiopathic hypertrophic pachymeningitis mimicking malignant tumor or high-grade meningioma. World Neurosurg. 134:372-6, 2019
                                2. Wang X et al: Intracranial inflammatory myofibroblastic tumor with negative expression of anaplastic lymphoma kinase: a case report and review of the literature. World Neurosurg. 125:117-22, 2019
                                3. Lata KA et al: A rare case of inflammatory myofibroblastic tumor of meninges. J Pediatr Neurosci. 13(2):255-9, 2018
                                4. Zhang Z et al: IgG4-related inflammatory pseudotumor of the brain parenchyma: a case report and literature review. Acta Neurol Belg. 118(4):617-27, 2018
                                5. Gautam S et al: Intracranial inflammatory pseudotumor presenting as an en plaque mass. Neurol India. 65(5):1169-70, 2017
                                6. Yuan C et al: Metastatic anaplastic lymphoma kinase-1 (ALK-1)-rearranged inflammatory myofibroblastic sarcoma to the brain with leptomeningeal involvement: favorable response to serial ALK inhibitors: a case report. Am J Case Rep. 18:799-804, 2017
                                7. Surabhi VR et al: Inflammatory myofibroblastic tumors: current update. Radiol Clin North Am. 54(3):553-63, 2016
                                8. Killeen T et al: Solitary tumour-like mass lesions of the central nervous system: primary angiitis of the CNS and inflammatory pseudotumour. Clin Neurol Neurosurg. 135:34-7, 2015
                                9. Kim JH et al: Imaging features of meningeal inflammatory myofibroblastic tumor. AJNR Am J Neuroradiol. 30(6):1261-7, 2009
                                10. Swain RS et al: Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol. 39(3):410-9, 2008
                                11. Hausler M et al: Inflammatory pseudotumors of the central nervous system: report of 3 cases and a literature review. Hum Pathol. 34(3):253-62, 2003
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Inflammatory myofibroblastic tumor (IMT)
                                        • Synonyms

                                          • Plasma cell granuloma, myofibrohistiocytic proliferation
                                          • Not inflammatory pseudotumor (nonneoplastic process of unknown etiology)
                                          • Not idiopathic hypertrophic pachymeningitis
                                        • Definitions

                                          • Spindle cell neoplasm of intermediate biological potential with conspicuous inflammatory background
                                          • Clonal neoplasm with ALK gene rearrangements/translocations in 50-70%

                                        IMAGING

                                        • General Features

                                          • CT Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Staging, Grading, & Classification

                                                      • Gross Pathologic & Surgical Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Han MS et al: Intracranial inflammatory pseudotumor associated with idiopathic hypertrophic pachymeningitis mimicking malignant tumor or high-grade meningioma. World Neurosurg. 134:372-6, 2019
                                                              2. Wang X et al: Intracranial inflammatory myofibroblastic tumor with negative expression of anaplastic lymphoma kinase: a case report and review of the literature. World Neurosurg. 125:117-22, 2019
                                                              3. Lata KA et al: A rare case of inflammatory myofibroblastic tumor of meninges. J Pediatr Neurosci. 13(2):255-9, 2018
                                                              4. Zhang Z et al: IgG4-related inflammatory pseudotumor of the brain parenchyma: a case report and literature review. Acta Neurol Belg. 118(4):617-27, 2018
                                                              5. Gautam S et al: Intracranial inflammatory pseudotumor presenting as an en plaque mass. Neurol India. 65(5):1169-70, 2017
                                                              6. Yuan C et al: Metastatic anaplastic lymphoma kinase-1 (ALK-1)-rearranged inflammatory myofibroblastic sarcoma to the brain with leptomeningeal involvement: favorable response to serial ALK inhibitors: a case report. Am J Case Rep. 18:799-804, 2017
                                                              7. Surabhi VR et al: Inflammatory myofibroblastic tumors: current update. Radiol Clin North Am. 54(3):553-63, 2016
                                                              8. Killeen T et al: Solitary tumour-like mass lesions of the central nervous system: primary angiitis of the CNS and inflammatory pseudotumour. Clin Neurol Neurosurg. 135:34-7, 2015
                                                              9. Kim JH et al: Imaging features of meningeal inflammatory myofibroblastic tumor. AJNR Am J Neuroradiol. 30(6):1261-7, 2009
                                                              10. Swain RS et al: Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol. 39(3):410-9, 2008
                                                              11. Hausler M et al: Inflammatory pseudotumors of the central nervous system: report of 3 cases and a literature review. Hum Pathol. 34(3):253-62, 2003