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Inflammatory Myopathy
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Synonyms

            • Idiopathic inflammatory myopathy
          • Definitions

            • Inflammation and damage to skeletal muscle with ↑ in muscle-derived proteins (creatine kinase)
              • Diffuse: Polymyositis (PM), dermatomyositis (DM)
              • Focal patterns: Inclusion body myositis (IBM), focal myositis (FM; may progress to PM)

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Delavan JA et al: Gemcitabine-induced radiation recall myositis. Skeletal Radiol. 44(3):451-5, 2015
                                  2. Jarraya M et al: Atypical proliferative myositis: original MR description with pathologic correlation: case report. Skeletal Radiol. 43(8):1155-9, 2014
                                  3. Yoshida K et al: Fasciitis as a common lesion of dermatomyositis, demonstrated early after disease onset by en bloc biopsy combined with magnetic resonance imaging. Arthritis Rheum. 62(12):3751-9, 2010
                                  4. Gardner-Medwin JM et al: MRI in juvenile idiopathic arthritis and juvenile dermatomyositis. Ann N Y Acad Sci. 1154:52-83, 2009
                                  5. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                  6. Tomasová Studynková J et al: The role of MRI in the assessment of polymyositis and dermatomyositis. Rheumatology (Oxford). 46(7):1174-9, 2007
                                  7. Chan WP et al: MR imaging of primary skeletal muscle diseases in children. AJR Am J Roentgenol. 179(4):989-97, 2002
                                  8. O'Connell MJ et al: Whole-body MR imaging in the diagnosis of polymyositis. AJR Am J Roentgenol. 179(4):967-71, 2002
                                  9. Adams EM et al: The idiopathic inflammatory myopathies: spectrum of MR imaging findings. Radiographics. 15(3):563-74, 1995
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          TERMINOLOGY

                                          • Synonyms

                                            • Idiopathic inflammatory myopathy
                                          • Definitions

                                            • Inflammation and damage to skeletal muscle with ↑ in muscle-derived proteins (creatine kinase)
                                              • Diffuse: Polymyositis (PM), dermatomyositis (DM)
                                              • Focal patterns: Inclusion body myositis (IBM), focal myositis (FM; may progress to PM)

                                          IMAGING

                                          • General Features

                                            • Imaging Recommendations

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Delavan JA et al: Gemcitabine-induced radiation recall myositis. Skeletal Radiol. 44(3):451-5, 2015
                                                                  2. Jarraya M et al: Atypical proliferative myositis: original MR description with pathologic correlation: case report. Skeletal Radiol. 43(8):1155-9, 2014
                                                                  3. Yoshida K et al: Fasciitis as a common lesion of dermatomyositis, demonstrated early after disease onset by en bloc biopsy combined with magnetic resonance imaging. Arthritis Rheum. 62(12):3751-9, 2010
                                                                  4. Gardner-Medwin JM et al: MRI in juvenile idiopathic arthritis and juvenile dermatomyositis. Ann N Y Acad Sci. 1154:52-83, 2009
                                                                  5. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                                                  6. Tomasová Studynková J et al: The role of MRI in the assessment of polymyositis and dermatomyositis. Rheumatology (Oxford). 46(7):1174-9, 2007
                                                                  7. Chan WP et al: MR imaging of primary skeletal muscle diseases in children. AJR Am J Roentgenol. 179(4):989-97, 2002
                                                                  8. O'Connell MJ et al: Whole-body MR imaging in the diagnosis of polymyositis. AJR Am J Roentgenol. 179(4):967-71, 2002
                                                                  9. Adams EM et al: The idiopathic inflammatory myopathies: spectrum of MR imaging findings. Radiographics. 15(3):563-74, 1995