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Interhemispheric Cyst/AVID
Emily Edwards, MD; Paula J. Woodward, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Interhemispheric cyst (IHC)
                • Asymmetric ventriculomegaly with IHC and dysgenesis of corpus callosum (AVID)
              • Synonyms

                • Ependymal cyst
                • Neuroepithelial cyst
                • Glioependymal cyst
              • Definitions

                • Intracranial cyst centered near midline/interhemispheric fissure
                • Type 1 cyst: Communicates with ventricular system
                  • Type 1a (most common) associated with hydrocephalus
                  • Types 1b, 1c have additional anomalies
                • Type 2 cyst: Intraparenchymal

              IMAGING

              • General Features

                • Ultrasonographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Oh KY et al: Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID). Prenat Diagn. 39(1):26-32, 2019
                                          2. Uccella S et al: Dissecting the neurological phenotype in children with callosal agenesis, interhemispheric cysts and malformations of cortical development. J Neurol. 266(5):1167-81, 2019
                                          3. Revanna KG et al: Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome. BMJ Case Rep. 11(1), 2018
                                          4. Edwards TJ et al: Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain. 137(Pt 6):1579-613, 2014
                                          5. Cagneaux M et al: Agenesis of the corpus callosum with interhemispheric cyst, associated with aberrant cortical sulci and without underlying cortical dysplasia. Ultrasound Obstet Gynecol. 42(5):603-5, 2013
                                          6. Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
                                          7. Oh KY et al: Asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID): an imaging triad. J Ultrasound Med. 31(11):1811-20, 2012
                                          8. Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
                                          9. Wong SK et al: Supratentorial abnormalities in the Chiari II malformation, III: the interhemispheric cyst. J Ultrasound Med. 28(8):999-1006, 2009
                                          10. Moriyama E et al: Interhemispheric multiloculated ependymal cyst with dysgenesis of the corpus callosum: a case in a preterm fetus. Childs Nerv Syst. 23(7):807-13, 2007
                                          11. Mühler MR et al: Fetal MRI demonstrates glioependymal cyst in a case of sonographic unilateral ventriculomegaly. Pediatr Radiol. 37(4):391-5, 2007
                                          12. Utsunomiya H et al: Midline cystic malformations of the brain: imaging diagnosis and classification based on embryologic analysis. Radiat Med. 24(6):471-81, 2006
                                          13. Pavone P et al: Callosal anomalies with interhemispheric cyst: expanding the phenotype. Acta Paediatr. 94(8):1066-72, 2005
                                          14. Barkovich AJ et al: Callosal agenesis with cyst: a better understanding and new classification. Neurology. 56(2):220-7, 2001
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Interhemispheric cyst (IHC)
                                                        • Asymmetric ventriculomegaly with IHC and dysgenesis of corpus callosum (AVID)
                                                      • Synonyms

                                                        • Ependymal cyst
                                                        • Neuroepithelial cyst
                                                        • Glioependymal cyst
                                                      • Definitions

                                                        • Intracranial cyst centered near midline/interhemispheric fissure
                                                        • Type 1 cyst: Communicates with ventricular system
                                                          • Type 1a (most common) associated with hydrocephalus
                                                          • Types 1b, 1c have additional anomalies
                                                        • Type 2 cyst: Intraparenchymal

                                                      IMAGING

                                                      • General Features

                                                        • Ultrasonographic Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Oh KY et al: Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID). Prenat Diagn. 39(1):26-32, 2019
                                                                                  2. Uccella S et al: Dissecting the neurological phenotype in children with callosal agenesis, interhemispheric cysts and malformations of cortical development. J Neurol. 266(5):1167-81, 2019
                                                                                  3. Revanna KG et al: Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome. BMJ Case Rep. 11(1), 2018
                                                                                  4. Edwards TJ et al: Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain. 137(Pt 6):1579-613, 2014
                                                                                  5. Cagneaux M et al: Agenesis of the corpus callosum with interhemispheric cyst, associated with aberrant cortical sulci and without underlying cortical dysplasia. Ultrasound Obstet Gynecol. 42(5):603-5, 2013
                                                                                  6. Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
                                                                                  7. Oh KY et al: Asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID): an imaging triad. J Ultrasound Med. 31(11):1811-20, 2012
                                                                                  8. Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
                                                                                  9. Wong SK et al: Supratentorial abnormalities in the Chiari II malformation, III: the interhemispheric cyst. J Ultrasound Med. 28(8):999-1006, 2009
                                                                                  10. Moriyama E et al: Interhemispheric multiloculated ependymal cyst with dysgenesis of the corpus callosum: a case in a preterm fetus. Childs Nerv Syst. 23(7):807-13, 2007
                                                                                  11. Mühler MR et al: Fetal MRI demonstrates glioependymal cyst in a case of sonographic unilateral ventriculomegaly. Pediatr Radiol. 37(4):391-5, 2007
                                                                                  12. Utsunomiya H et al: Midline cystic malformations of the brain: imaging diagnosis and classification based on embryologic analysis. Radiat Med. 24(6):471-81, 2006
                                                                                  13. Pavone P et al: Callosal anomalies with interhemispheric cyst: expanding the phenotype. Acta Paediatr. 94(8):1066-72, 2005
                                                                                  14. Barkovich AJ et al: Callosal agenesis with cyst: a better understanding and new classification. Neurology. 56(2):220-7, 2001