Asymmetric ventriculomegaly with IHC and dysgenesis of corpus callosum (AVID)
Synonyms
Ependymal cyst
Neuroepithelial cyst
Glioependymal cyst
Definitions
Intracranial cyst centered near midline/interhemispheric fissure
Type 1 cyst: Communicates with ventricular system
Type 1a (most common) associated with hydrocephalus
Types 1b, 1c have additional anomalies
Type 2 cyst: Intraparenchymal
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Oh KY et al: Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID). Prenat Diagn. 39(1):26-32, 2019
Uccella S et al: Dissecting the neurological phenotype in children with callosal agenesis, interhemispheric cysts and malformations of cortical development. J Neurol. 266(5):1167-81, 2019
Revanna KG et al: Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome. BMJ Case Rep. 11(1), 2018
Edwards TJ et al: Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain. 137(Pt 6):1579-613, 2014
Cagneaux M et al: Agenesis of the corpus callosum with interhemispheric cyst, associated with aberrant cortical sulci and without underlying cortical dysplasia. Ultrasound Obstet Gynecol. 42(5):603-5, 2013
Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
Oh KY et al: Asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID): an imaging triad. J Ultrasound Med. 31(11):1811-20, 2012
Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
Wong SK et al: Supratentorial abnormalities in the Chiari II malformation, III: the interhemispheric cyst. J Ultrasound Med. 28(8):999-1006, 2009
Moriyama E et al: Interhemispheric multiloculated ependymal cyst with dysgenesis of the corpus callosum: a case in a preterm fetus. Childs Nerv Syst. 23(7):807-13, 2007
Mühler MR et al: Fetal MRI demonstrates glioependymal cyst in a case of sonographic unilateral ventriculomegaly. Pediatr Radiol. 37(4):391-5, 2007
Utsunomiya H et al: Midline cystic malformations of the brain: imaging diagnosis and classification based on embryologic analysis. Radiat Med. 24(6):471-81, 2006
Pavone P et al: Callosal anomalies with interhemispheric cyst: expanding the phenotype. Acta Paediatr. 94(8):1066-72, 2005
Barkovich AJ et al: Callosal agenesis with cyst: a better understanding and new classification. Neurology. 56(2):220-7, 2001
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Interhemispheric cyst (IHC)
Asymmetric ventriculomegaly with IHC and dysgenesis of corpus callosum (AVID)
Synonyms
Ependymal cyst
Neuroepithelial cyst
Glioependymal cyst
Definitions
Intracranial cyst centered near midline/interhemispheric fissure
Type 1 cyst: Communicates with ventricular system
Type 1a (most common) associated with hydrocephalus
Types 1b, 1c have additional anomalies
Type 2 cyst: Intraparenchymal
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Oh KY et al: Clinical outcomes following prenatal diagnosis of asymmetric ventriculomegaly, interhemispheric cyst, and callosal dysgenesis (AVID). Prenat Diagn. 39(1):26-32, 2019
Uccella S et al: Dissecting the neurological phenotype in children with callosal agenesis, interhemispheric cysts and malformations of cortical development. J Neurol. 266(5):1167-81, 2019
Revanna KG et al: Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome. BMJ Case Rep. 11(1), 2018
Edwards TJ et al: Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain. 137(Pt 6):1579-613, 2014
Cagneaux M et al: Agenesis of the corpus callosum with interhemispheric cyst, associated with aberrant cortical sulci and without underlying cortical dysplasia. Ultrasound Obstet Gynecol. 42(5):603-5, 2013
Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
Oh KY et al: Asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID): an imaging triad. J Ultrasound Med. 31(11):1811-20, 2012
Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
Wong SK et al: Supratentorial abnormalities in the Chiari II malformation, III: the interhemispheric cyst. J Ultrasound Med. 28(8):999-1006, 2009
Moriyama E et al: Interhemispheric multiloculated ependymal cyst with dysgenesis of the corpus callosum: a case in a preterm fetus. Childs Nerv Syst. 23(7):807-13, 2007
Mühler MR et al: Fetal MRI demonstrates glioependymal cyst in a case of sonographic unilateral ventriculomegaly. Pediatr Radiol. 37(4):391-5, 2007
Utsunomiya H et al: Midline cystic malformations of the brain: imaging diagnosis and classification based on embryologic analysis. Radiat Med. 24(6):471-81, 2006
Pavone P et al: Callosal anomalies with interhemispheric cyst: expanding the phenotype. Acta Paediatr. 94(8):1066-72, 2005
Barkovich AJ et al: Callosal agenesis with cyst: a better understanding and new classification. Neurology. 56(2):220-7, 2001
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