Mesenchymal tumor of GI tract derived from interstitial cells of Cajal
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Fluoroscopic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Patel DJ et al: Adjuvant systemic therapy for small bowel gastrointestinal stromal tumor (GIST): is there a survival benefit after R0 resection? Surgery. 168(4):695-700, 2020
Feng C et al: Tumor heterogeneity in gastrointestinal stromal tumors of the small bowel: volumetric CT texture analysis as a potential biomarker for risk stratification. Cancer Imaging. 18(1):46, 2018
Maldonado FJ et al: Reproducible imaging features of biologically aggressive gastrointestinal stromal tumors of the small bowel. Abdom Radiol (NY). 43(7):1567-74, 2018
Corless CL et al: Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. J Clin Oncol. 32(15):1563-70, 2014
Tap WD et al: That's the "GIST" of it: use of adjuvant imatinib after resection of a primary GI stromal tumor. J Clin Oncol. 32(15):1543-6, 2014
Miettinen M et al: True smooth muscle tumors of the small intestine: a clinicopathologic, immunhistochemical, and molecular genetic study of 25 cases. Am J Surg Pathol. 33(3):430-6, 2009
Nakajima T et al: Interstitial cells of Cajal do not harbor c-kit or PDGFRA gene mutations in patients with sporadic gastrointestinal stromal tumors. J Gastroenterol. 44(5):426-31, 2009
Yamamoto H et al: Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q. J Cancer Res Clin Oncol. 135(6):791-8, 2009
Scarpa M et al: A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J Surg Oncol. 98(5):384-92, 2008
Ulusan S et al: Gastrointestinal stromal tumours: CT findings. Br J Radiol. 81(968):618-23, 2008
King DM: The radiology of gastrointestinal stromal tumours (GIST). Cancer Imaging. 5:150-6, 2005
Logroño R et al: Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther. 3(3):251-8, 2004
Bechtold RE et al: Cystic changes in hepatic and peritoneal metastases from gastrointestinal stromal tumors treated with Gleevec. Abdom Imaging. 28(6):808-14, 2003
Burkill GJ et al: Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology. 226(2):527-32, 2003
Tateishi U et al: Gastrointestinal stromal tumor. Correlation of computed tomography findings with tumor grade and mortality. J Comput Assist Tomogr. 27(5):792-8, 2003
Buckley JA et al: CT evaluation of small bowel neoplasms: spectrum of disease. Radiographics. 18(2):379-92, 1998
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
GI stromal tumor (GIST)
Definitions
Mesenchymal tumor of GI tract derived from interstitial cells of Cajal
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Fluoroscopic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Patel DJ et al: Adjuvant systemic therapy for small bowel gastrointestinal stromal tumor (GIST): is there a survival benefit after R0 resection? Surgery. 168(4):695-700, 2020
Feng C et al: Tumor heterogeneity in gastrointestinal stromal tumors of the small bowel: volumetric CT texture analysis as a potential biomarker for risk stratification. Cancer Imaging. 18(1):46, 2018
Maldonado FJ et al: Reproducible imaging features of biologically aggressive gastrointestinal stromal tumors of the small bowel. Abdom Radiol (NY). 43(7):1567-74, 2018
Corless CL et al: Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. J Clin Oncol. 32(15):1563-70, 2014
Tap WD et al: That's the "GIST" of it: use of adjuvant imatinib after resection of a primary GI stromal tumor. J Clin Oncol. 32(15):1543-6, 2014
Miettinen M et al: True smooth muscle tumors of the small intestine: a clinicopathologic, immunhistochemical, and molecular genetic study of 25 cases. Am J Surg Pathol. 33(3):430-6, 2009
Nakajima T et al: Interstitial cells of Cajal do not harbor c-kit or PDGFRA gene mutations in patients with sporadic gastrointestinal stromal tumors. J Gastroenterol. 44(5):426-31, 2009
Yamamoto H et al: Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q. J Cancer Res Clin Oncol. 135(6):791-8, 2009
Scarpa M et al: A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J Surg Oncol. 98(5):384-92, 2008
Ulusan S et al: Gastrointestinal stromal tumours: CT findings. Br J Radiol. 81(968):618-23, 2008
King DM: The radiology of gastrointestinal stromal tumours (GIST). Cancer Imaging. 5:150-6, 2005
Logroño R et al: Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther. 3(3):251-8, 2004
Bechtold RE et al: Cystic changes in hepatic and peritoneal metastases from gastrointestinal stromal tumors treated with Gleevec. Abdom Imaging. 28(6):808-14, 2003
Burkill GJ et al: Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology. 226(2):527-32, 2003
Tateishi U et al: Gastrointestinal stromal tumor. Correlation of computed tomography findings with tumor grade and mortality. J Comput Assist Tomogr. 27(5):792-8, 2003
Buckley JA et al: CT evaluation of small bowel neoplasms: spectrum of disease. Radiographics. 18(2):379-92, 1998
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