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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Intralabyrinthine schwannoma (ILS)
Synonyms
- Inner ear schwannoma
Definitions
- ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
- Includes schwannomas of cochlea, vestibule, or both as well as tumors of inner ear extending to internal auditory canal (IAC) or middle ear
- ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Totten DJ et al: Management of vestibular dysfunction and hearing loss in intralabyrinthine schwannomas. Am J Otolaryngol. 42(4):102984, 2021
- Bagattini M et al: Histopathologic evaluation of intralabyrinthine schwannoma. Audiol Neurootol. 1-8, 2020
- Cho SJ et al: Diagnostic assessment of magnetic resonance imaging for patients with intralabyrinthine schwannoma: a systematic review. J Neuroradiol. ePub, 2020
- Choudhury B et al: Intralabyrinthine schwannomas: disease presentation, tumor management, and hearing rehabilitation. J Neurol Surg B Skull Base. 80(2):196-202, 2019
- Bae YJ et al: Differentiation between intralabyrinthine schwannoma and contrast-enhancing labyrinthitis on MRI: quantitative analysis of signal intensity Characteristics. Otol Neurotol. 39(8):1045-52, 2018
- Marinelli JP et al: Incidence of intralabyrinthine schwannoma: a population-based study within the United States. Otol Neurotol. 39(9):1191-4, 2018
- Frisch CD et al: Intralabyrinthine schwannomas. Otolaryngol Clin North Am. 48(3):423-41, 2015
- Gosselin É et al: Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: conservative management vs. microsurgery. Eur Arch Otorhinolaryngol. 273(6):1357-67, 2015
- Lee JJ et al: Recovery of hearing after surgical removal of intralabyrinthine schwannoma. Laryngoscope. 125(8):1968-71, 2015
- Slattery EL et al: Intralabyrinthine schwannomas mimic cochleovestibular disease: symptoms from tumor mass effect in the labyrinth. Otol Neurotol. 36(1):167-71, 2015
- Dubernard X et al: Clinical presentation of intralabyrinthine schwannomas: a multicenter study of 110 cases. Otol Neurotol. 35(9):1641-9, 2014
- Peng R et al: Intensity of gadolinium enhancement on MRI is useful in differentiation of intracochlear inflammation from tumor. Otol Neurotol. 35(5):905-10, 2014
- Schutt CA et al: Cochlear implantation after resection of an intralabyrinthine schwannoma. Am J Otolaryngol. 35(2):257-60, 2014
- Van Abel KM et al: Primary inner ear schwannomas: a case series and systematic review of the literature. Laryngoscope. 123(8):1957-66, 2013
- Salzman KL et al: Intralabyrinthine schwannomas: imaging diagnosis and classification. AJNR Am J Neuroradiol. 33(1):104-9, 2012
- Dubrulle F et al: Differential diagnosis and prognosis of T1-weighted post-gadolinium intralabyrinthine hyperintensities. Eur Radiol. 20(11):2628-36, 2010
- Iseri M et al: Hearing loss owing to intralabyrinthine schwannoma responsive to intratympanic steroid treatment. J Otolaryngol Head Neck Surg. 38(3):E95-7, 2009
- Shin YR et al: Intralabyrinthine schwannoma involving the cochlea, vestibule, and internal auditory canal: 'canalolabyrinthine schwannoma'. Eur Arch Otorhinolaryngol. 266(1):143-5, 2009
- Jia H et al: Intralabyrinthine schwannomas: symptoms and managements. Auris Nasus Larynx. 35(1):131-6, 2008
- Tieleman A et al: Imaging of intralabyrinthine schwannomas: a retrospective study of 52 cases with emphasis on lesion growth. AJNR Am J Neuroradiol. 29(5):898-905, 2008
- Di Lella F et al: Management of intralabyrinthine schwannomas. Auris Nasus Larynx. 34(4):459-63, 2007
- Machner B et al: Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits. J Neurol Neurosurg Psychiatry. 78(7):772-4, 2007
- Kennedy RJ et al: Intralabyrinthine schwannomas: diagnosis, management, and a new classification system. Otol Neurotol. 25(2):160-7, 2004
- Falcioni M et al: Inner ear extension of vestibular schwannomas. Laryngoscope. 113(9):1605-8, 2003
- Jackson LE et al: Intralabyrinthine schwannoma: subtle differentiating symptomatology. Otolaryngol Head Neck Surg. 129(4):439-40, 2003
- Neff BA et al: Intralabyrinthine schwannomas. Otol Neurotol. 24(2):299-307, 2003
- Hegarty JL et al: The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease. Laryngoscope. 112(1):8-17, 2002
- Green JD Jr et al: Diagnosis and management of intralabyrinthine schwannomas. Laryngoscope. 109(10):1626-31, 1999
- Deux JF et al: Slow-growing labyrinthine masses: contribution of MRI to diagnosis, follow-up and treatment. Neuroradiology. 40(10):684-9, 1998
- Mafee MF: MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. Otolaryngol Clin North Am. 28(3):407-30, 1995
- Saeed SR et al: Intralabyrinthine schwannoma shown by magnetic resonance imaging. Neuroradiology. 36(1):63-4, 1994
- Sataloff RT et al: Intralabyrinthine schwannoma. Am J Otol. 9(4):323-6, 1988
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Intralabyrinthine schwannoma (ILS)
Synonyms
- Inner ear schwannoma
Definitions
- ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
- Includes schwannomas of cochlea, vestibule, or both as well as tumors of inner ear extending to internal auditory canal (IAC) or middle ear
- ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Totten DJ et al: Management of vestibular dysfunction and hearing loss in intralabyrinthine schwannomas. Am J Otolaryngol. 42(4):102984, 2021
- Bagattini M et al: Histopathologic evaluation of intralabyrinthine schwannoma. Audiol Neurootol. 1-8, 2020
- Cho SJ et al: Diagnostic assessment of magnetic resonance imaging for patients with intralabyrinthine schwannoma: a systematic review. J Neuroradiol. ePub, 2020
- Choudhury B et al: Intralabyrinthine schwannomas: disease presentation, tumor management, and hearing rehabilitation. J Neurol Surg B Skull Base. 80(2):196-202, 2019
- Bae YJ et al: Differentiation between intralabyrinthine schwannoma and contrast-enhancing labyrinthitis on MRI: quantitative analysis of signal intensity Characteristics. Otol Neurotol. 39(8):1045-52, 2018
- Marinelli JP et al: Incidence of intralabyrinthine schwannoma: a population-based study within the United States. Otol Neurotol. 39(9):1191-4, 2018
- Frisch CD et al: Intralabyrinthine schwannomas. Otolaryngol Clin North Am. 48(3):423-41, 2015
- Gosselin É et al: Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: conservative management vs. microsurgery. Eur Arch Otorhinolaryngol. 273(6):1357-67, 2015
- Lee JJ et al: Recovery of hearing after surgical removal of intralabyrinthine schwannoma. Laryngoscope. 125(8):1968-71, 2015
- Slattery EL et al: Intralabyrinthine schwannomas mimic cochleovestibular disease: symptoms from tumor mass effect in the labyrinth. Otol Neurotol. 36(1):167-71, 2015
- Dubernard X et al: Clinical presentation of intralabyrinthine schwannomas: a multicenter study of 110 cases. Otol Neurotol. 35(9):1641-9, 2014
- Peng R et al: Intensity of gadolinium enhancement on MRI is useful in differentiation of intracochlear inflammation from tumor. Otol Neurotol. 35(5):905-10, 2014
- Schutt CA et al: Cochlear implantation after resection of an intralabyrinthine schwannoma. Am J Otolaryngol. 35(2):257-60, 2014
- Van Abel KM et al: Primary inner ear schwannomas: a case series and systematic review of the literature. Laryngoscope. 123(8):1957-66, 2013
- Salzman KL et al: Intralabyrinthine schwannomas: imaging diagnosis and classification. AJNR Am J Neuroradiol. 33(1):104-9, 2012
- Dubrulle F et al: Differential diagnosis and prognosis of T1-weighted post-gadolinium intralabyrinthine hyperintensities. Eur Radiol. 20(11):2628-36, 2010
- Iseri M et al: Hearing loss owing to intralabyrinthine schwannoma responsive to intratympanic steroid treatment. J Otolaryngol Head Neck Surg. 38(3):E95-7, 2009
- Shin YR et al: Intralabyrinthine schwannoma involving the cochlea, vestibule, and internal auditory canal: 'canalolabyrinthine schwannoma'. Eur Arch Otorhinolaryngol. 266(1):143-5, 2009
- Jia H et al: Intralabyrinthine schwannomas: symptoms and managements. Auris Nasus Larynx. 35(1):131-6, 2008
- Tieleman A et al: Imaging of intralabyrinthine schwannomas: a retrospective study of 52 cases with emphasis on lesion growth. AJNR Am J Neuroradiol. 29(5):898-905, 2008
- Di Lella F et al: Management of intralabyrinthine schwannomas. Auris Nasus Larynx. 34(4):459-63, 2007
- Machner B et al: Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits. J Neurol Neurosurg Psychiatry. 78(7):772-4, 2007
- Kennedy RJ et al: Intralabyrinthine schwannomas: diagnosis, management, and a new classification system. Otol Neurotol. 25(2):160-7, 2004
- Falcioni M et al: Inner ear extension of vestibular schwannomas. Laryngoscope. 113(9):1605-8, 2003
- Jackson LE et al: Intralabyrinthine schwannoma: subtle differentiating symptomatology. Otolaryngol Head Neck Surg. 129(4):439-40, 2003
- Neff BA et al: Intralabyrinthine schwannomas. Otol Neurotol. 24(2):299-307, 2003
- Hegarty JL et al: The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease. Laryngoscope. 112(1):8-17, 2002
- Green JD Jr et al: Diagnosis and management of intralabyrinthine schwannomas. Laryngoscope. 109(10):1626-31, 1999
- Deux JF et al: Slow-growing labyrinthine masses: contribution of MRI to diagnosis, follow-up and treatment. Neuroradiology. 40(10):684-9, 1998
- Mafee MF: MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. Otolaryngol Clin North Am. 28(3):407-30, 1995
- Saeed SR et al: Intralabyrinthine schwannoma shown by magnetic resonance imaging. Neuroradiology. 36(1):63-4, 1994
- Sataloff RT et al: Intralabyrinthine schwannoma. Am J Otol. 9(4):323-6, 1988
