ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
Includes schwannomas of cochlea, vestibule, or both as well as tumors of inner ear extending to internal auditory canal (IAC) or middle ear
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Totten DJ et al: Management of vestibular dysfunction and hearing loss in intralabyrinthine schwannomas. Am J Otolaryngol. 42(4):102984, 2021
Bagattini M et al: Histopathologic evaluation of intralabyrinthine schwannoma. Audiol Neurootol. 1-8, 2020
Cho SJ et al: Diagnostic assessment of magnetic resonance imaging for patients with intralabyrinthine schwannoma: a systematic review. J Neuroradiol. ePub, 2020
Choudhury B et al: Intralabyrinthine schwannomas: disease presentation, tumor management, and hearing rehabilitation. J Neurol Surg B Skull Base. 80(2):196-202, 2019
Bae YJ et al: Differentiation between intralabyrinthine schwannoma and contrast-enhancing labyrinthitis on MRI: quantitative analysis of signal intensity Characteristics. Otol Neurotol. 39(8):1045-52, 2018
Marinelli JP et al: Incidence of intralabyrinthine schwannoma: a population-based study within the United States. Otol Neurotol. 39(9):1191-4, 2018
Frisch CD et al: Intralabyrinthine schwannomas. Otolaryngol Clin North Am. 48(3):423-41, 2015
Gosselin É et al: Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: conservative management vs. microsurgery. Eur Arch Otorhinolaryngol. 273(6):1357-67, 2015
Lee JJ et al: Recovery of hearing after surgical removal of intralabyrinthine schwannoma. Laryngoscope. 125(8):1968-71, 2015
Slattery EL et al: Intralabyrinthine schwannomas mimic cochleovestibular disease: symptoms from tumor mass effect in the labyrinth. Otol Neurotol. 36(1):167-71, 2015
Dubernard X et al: Clinical presentation of intralabyrinthine schwannomas: a multicenter study of 110 cases. Otol Neurotol. 35(9):1641-9, 2014
Peng R et al: Intensity of gadolinium enhancement on MRI is useful in differentiation of intracochlear inflammation from tumor. Otol Neurotol. 35(5):905-10, 2014
Schutt CA et al: Cochlear implantation after resection of an intralabyrinthine schwannoma. Am J Otolaryngol. 35(2):257-60, 2014
Van Abel KM et al: Primary inner ear schwannomas: a case series and systematic review of the literature. Laryngoscope. 123(8):1957-66, 2013
Salzman KL et al: Intralabyrinthine schwannomas: imaging diagnosis and classification. AJNR Am J Neuroradiol. 33(1):104-9, 2012
Dubrulle F et al: Differential diagnosis and prognosis of T1-weighted post-gadolinium intralabyrinthine hyperintensities. Eur Radiol. 20(11):2628-36, 2010
Iseri M et al: Hearing loss owing to intralabyrinthine schwannoma responsive to intratympanic steroid treatment. J Otolaryngol Head Neck Surg. 38(3):E95-7, 2009
Shin YR et al: Intralabyrinthine schwannoma involving the cochlea, vestibule, and internal auditory canal: 'canalolabyrinthine schwannoma'. Eur Arch Otorhinolaryngol. 266(1):143-5, 2009
Jia H et al: Intralabyrinthine schwannomas: symptoms and managements. Auris Nasus Larynx. 35(1):131-6, 2008
Tieleman A et al: Imaging of intralabyrinthine schwannomas: a retrospective study of 52 cases with emphasis on lesion growth. AJNR Am J Neuroradiol. 29(5):898-905, 2008
Di Lella F et al: Management of intralabyrinthine schwannomas. Auris Nasus Larynx. 34(4):459-63, 2007
Machner B et al: Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits. J Neurol Neurosurg Psychiatry. 78(7):772-4, 2007
Kennedy RJ et al: Intralabyrinthine schwannomas: diagnosis, management, and a new classification system. Otol Neurotol. 25(2):160-7, 2004
Falcioni M et al: Inner ear extension of vestibular schwannomas. Laryngoscope. 113(9):1605-8, 2003
Jackson LE et al: Intralabyrinthine schwannoma: subtle differentiating symptomatology. Otolaryngol Head Neck Surg. 129(4):439-40, 2003
Neff BA et al: Intralabyrinthine schwannomas. Otol Neurotol. 24(2):299-307, 2003
Hegarty JL et al: The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease. Laryngoscope. 112(1):8-17, 2002
Green JD Jr et al: Diagnosis and management of intralabyrinthine schwannomas. Laryngoscope. 109(10):1626-31, 1999
Deux JF et al: Slow-growing labyrinthine masses: contribution of MRI to diagnosis, follow-up and treatment. Neuroradiology. 40(10):684-9, 1998
Mafee MF: MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. Otolaryngol Clin North Am. 28(3):407-30, 1995
Saeed SR et al: Intralabyrinthine schwannoma shown by magnetic resonance imaging. Neuroradiology. 36(1):63-4, 1994
Sataloff RT et al: Intralabyrinthine schwannoma. Am J Otol. 9(4):323-6, 1988
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Intralabyrinthine schwannoma (ILS)
Synonyms
Inner ear schwannoma
Definitions
ILS: Benign tumor arising from Schwann cells within structures of membranous labyrinth
Includes schwannomas of cochlea, vestibule, or both as well as tumors of inner ear extending to internal auditory canal (IAC) or middle ear
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Totten DJ et al: Management of vestibular dysfunction and hearing loss in intralabyrinthine schwannomas. Am J Otolaryngol. 42(4):102984, 2021
Bagattini M et al: Histopathologic evaluation of intralabyrinthine schwannoma. Audiol Neurootol. 1-8, 2020
Cho SJ et al: Diagnostic assessment of magnetic resonance imaging for patients with intralabyrinthine schwannoma: a systematic review. J Neuroradiol. ePub, 2020
Choudhury B et al: Intralabyrinthine schwannomas: disease presentation, tumor management, and hearing rehabilitation. J Neurol Surg B Skull Base. 80(2):196-202, 2019
Bae YJ et al: Differentiation between intralabyrinthine schwannoma and contrast-enhancing labyrinthitis on MRI: quantitative analysis of signal intensity Characteristics. Otol Neurotol. 39(8):1045-52, 2018
Marinelli JP et al: Incidence of intralabyrinthine schwannoma: a population-based study within the United States. Otol Neurotol. 39(9):1191-4, 2018
Frisch CD et al: Intralabyrinthine schwannomas. Otolaryngol Clin North Am. 48(3):423-41, 2015
Gosselin É et al: Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: conservative management vs. microsurgery. Eur Arch Otorhinolaryngol. 273(6):1357-67, 2015
Lee JJ et al: Recovery of hearing after surgical removal of intralabyrinthine schwannoma. Laryngoscope. 125(8):1968-71, 2015
Slattery EL et al: Intralabyrinthine schwannomas mimic cochleovestibular disease: symptoms from tumor mass effect in the labyrinth. Otol Neurotol. 36(1):167-71, 2015
Dubernard X et al: Clinical presentation of intralabyrinthine schwannomas: a multicenter study of 110 cases. Otol Neurotol. 35(9):1641-9, 2014
Peng R et al: Intensity of gadolinium enhancement on MRI is useful in differentiation of intracochlear inflammation from tumor. Otol Neurotol. 35(5):905-10, 2014
Schutt CA et al: Cochlear implantation after resection of an intralabyrinthine schwannoma. Am J Otolaryngol. 35(2):257-60, 2014
Van Abel KM et al: Primary inner ear schwannomas: a case series and systematic review of the literature. Laryngoscope. 123(8):1957-66, 2013
Salzman KL et al: Intralabyrinthine schwannomas: imaging diagnosis and classification. AJNR Am J Neuroradiol. 33(1):104-9, 2012
Dubrulle F et al: Differential diagnosis and prognosis of T1-weighted post-gadolinium intralabyrinthine hyperintensities. Eur Radiol. 20(11):2628-36, 2010
Iseri M et al: Hearing loss owing to intralabyrinthine schwannoma responsive to intratympanic steroid treatment. J Otolaryngol Head Neck Surg. 38(3):E95-7, 2009
Shin YR et al: Intralabyrinthine schwannoma involving the cochlea, vestibule, and internal auditory canal: 'canalolabyrinthine schwannoma'. Eur Arch Otorhinolaryngol. 266(1):143-5, 2009
Jia H et al: Intralabyrinthine schwannomas: symptoms and managements. Auris Nasus Larynx. 35(1):131-6, 2008
Tieleman A et al: Imaging of intralabyrinthine schwannomas: a retrospective study of 52 cases with emphasis on lesion growth. AJNR Am J Neuroradiol. 29(5):898-905, 2008
Di Lella F et al: Management of intralabyrinthine schwannomas. Auris Nasus Larynx. 34(4):459-63, 2007
Machner B et al: Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits. J Neurol Neurosurg Psychiatry. 78(7):772-4, 2007
Kennedy RJ et al: Intralabyrinthine schwannomas: diagnosis, management, and a new classification system. Otol Neurotol. 25(2):160-7, 2004
Falcioni M et al: Inner ear extension of vestibular schwannomas. Laryngoscope. 113(9):1605-8, 2003
Jackson LE et al: Intralabyrinthine schwannoma: subtle differentiating symptomatology. Otolaryngol Head Neck Surg. 129(4):439-40, 2003
Neff BA et al: Intralabyrinthine schwannomas. Otol Neurotol. 24(2):299-307, 2003
Hegarty JL et al: The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease. Laryngoscope. 112(1):8-17, 2002
Green JD Jr et al: Diagnosis and management of intralabyrinthine schwannomas. Laryngoscope. 109(10):1626-31, 1999
Deux JF et al: Slow-growing labyrinthine masses: contribution of MRI to diagnosis, follow-up and treatment. Neuroradiology. 40(10):684-9, 1998
Mafee MF: MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. Otolaryngol Clin North Am. 28(3):407-30, 1995
Saeed SR et al: Intralabyrinthine schwannoma shown by magnetic resonance imaging. Neuroradiology. 36(1):63-4, 1994
Sataloff RT et al: Intralabyrinthine schwannoma. Am J Otol. 9(4):323-6, 1988
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