link
Bookmarks
Breast
Histopathologic Diagnoses
Malignant Lesions
Invasive Lobular Carcinoma, Pleomorphic
Invasive Lobular Carcinoma, Pleomorphic
Jessica W. T. Leung, MD; Deanna L. Lane, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Subscribe
0
10
1
0

KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Pleomorphic invasive lobular carcinoma (pILC)

          • Definitions

            • Histopathologic variant of ILC exhibiting high nuclear grade: Large atypical nuclei and pleomorphism
            • All grade 3 ILC is pILC

          IMAGING

          • Mammographic Findings

            • Ultrasonographic Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Liu YL et al: Invasive lobular breast carcinoma: pleomorphic versus classical subtype, associations and prognosis. Clin Breast Cancer. 18(2):114-120, 2018
                                  2. Yeap PM et al: A comparison of the imaging features of pleomorphic and classical invasive lobular carcinoma. Breast Cancer Res Treat. ePub, 2018
                                  3. Zhu S et al: IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 3(8), 2018
                                  4. Altundag K: Prognosis of women with invasive pleomorphic lobular carcinoma compared with classical invasive lobular carcinoma: Still debatable issue? J BUON. 22(4):1086-1087, 2017
                                  5. Felts JL et al: An Analysis of Oncotype DX Recurrence Scores and Clinicopathologic Characteristics in Invasive Lobular Breast Cancer. Breast J. 23(6):677-686, 2017
                                  6. Sahin S et al: Invasive Pleomorphic Lobular Histology Is an Adverse Prognostic Factor on Survival in Patients with Breast Cancer. Am Surg. 83(4):359-364, 2017
                                  7. Yang LP et al: Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study. Cancer Med. 6(12):2867-2875, 2017
                                  8. Dieci MV et al: Whole exome sequencing of rare aggressive breast cancer histologies. Breast Cancer Res Treat. 156(1):21-32, 2016
                                  9. Ilic IR et al: Seven-year survey of classical and pleomorphic invasive lobular breast carcinomas in women from southeastern Serbia: Differences in clinicopathological and immunohistochemical features. J BUON. 21(5):1113-1120, 2016
                                  10. Al-Baimani K et al: Invasive Pleomorphic Lobular Carcinoma of the Breast: Pathologic, Clinical, and Therapeutic Considerations. Clin Breast Cancer. 15(6):421-5, 2015
                                  11. Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
                                  12. Guiu S et al: Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions? Crit Rev Oncol Hematol. 92(3):235-257, 2014
                                  13. Jung HN et al: Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast? Breast. 22(3):324-9, 2013
                                  14. Rakha EA et al: Pleomorphic lobular carcinoma of the breast: is it a prognostically significant pathological subtype independent of histological grade? Mod Pathol. 26(4):496-501, 2013
                                  15. Jacobs M et al: Clinicopathologic and biomarker analysis of invasive pleomorphic lobular carcinoma as compared with invasive classic lobular carcinoma: an experience in our institution and review of the literature. Ann Diagn Pathol. 16(3):185-9, 2012
                                  16. Jung HN et al: Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast? Breast. Epub ahead of print, 2012
                                  17. Jung SP et al: Invasive pleomorphic lobular carcinoma of the breast: clinicopathologic characteristics and prognosis compared with invasive ductal carcinoma. J Breast Cancer. 15(3):313-9, 2012
                                  18. Monhollen L et al: Pleomorphic lobular carcinoma: a distinctive clinical and molecular breast cancer type. Histopathology. 61(3):365-77, 2012
                                  19. Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
                                  20. Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
                                  21. Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
                                  22. Lopez JK et al: Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 29(1):165-76, 2009
                                  23. Vargas AC et al: Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact. Future Oncol. 5(2):233-43, 2009
                                  24. Buchanan CL et al: Is pleomorphic lobular carcinoma really a distinct clinical entity? J Surg Oncol. 98(5):314-7, 2008
                                  25. Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
                                  26. Maly B et al: Pleomorphic variant of invasive lobular carcinoma of the male breast. Virchows Arch. 446(3):344-5, 2005
                                  27. Moe RE et al: Distinctive biology of pleomorphic lobular carcinoma of the breast. J Surg Oncol. 90(2):47-50, 2005
                                  28. Reis-Filho JS et al: Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity. J Pathol. 207(1):1-13, 2005
                                  29. Varga Z et al: Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer. Histopathology. 44(4):332-8, 2004
                                  30. Tot T: The diffuse type of invasive lobular carcinoma of the breast: morphology and prognosis. Virchows Arch. 443(6):718-24, 2003
                                  31. Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
                                  32. Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001
                                  Related Anatomy
                                  Loading...
                                  Related Differential Diagnoses
                                  Loading...
                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Pleomorphic invasive lobular carcinoma (pILC)

                                          • Definitions

                                            • Histopathologic variant of ILC exhibiting high nuclear grade: Large atypical nuclei and pleomorphism
                                            • All grade 3 ILC is pILC

                                          IMAGING

                                          • Mammographic Findings

                                            • Ultrasonographic Findings

                                              • MR Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Staging, Grading, & Classification

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Liu YL et al: Invasive lobular breast carcinoma: pleomorphic versus classical subtype, associations and prognosis. Clin Breast Cancer. 18(2):114-120, 2018
                                                                  2. Yeap PM et al: A comparison of the imaging features of pleomorphic and classical invasive lobular carcinoma. Breast Cancer Res Treat. ePub, 2018
                                                                  3. Zhu S et al: IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 3(8), 2018
                                                                  4. Altundag K: Prognosis of women with invasive pleomorphic lobular carcinoma compared with classical invasive lobular carcinoma: Still debatable issue? J BUON. 22(4):1086-1087, 2017
                                                                  5. Felts JL et al: An Analysis of Oncotype DX Recurrence Scores and Clinicopathologic Characteristics in Invasive Lobular Breast Cancer. Breast J. 23(6):677-686, 2017
                                                                  6. Sahin S et al: Invasive Pleomorphic Lobular Histology Is an Adverse Prognostic Factor on Survival in Patients with Breast Cancer. Am Surg. 83(4):359-364, 2017
                                                                  7. Yang LP et al: Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study. Cancer Med. 6(12):2867-2875, 2017
                                                                  8. Dieci MV et al: Whole exome sequencing of rare aggressive breast cancer histologies. Breast Cancer Res Treat. 156(1):21-32, 2016
                                                                  9. Ilic IR et al: Seven-year survey of classical and pleomorphic invasive lobular breast carcinomas in women from southeastern Serbia: Differences in clinicopathological and immunohistochemical features. J BUON. 21(5):1113-1120, 2016
                                                                  10. Al-Baimani K et al: Invasive Pleomorphic Lobular Carcinoma of the Breast: Pathologic, Clinical, and Therapeutic Considerations. Clin Breast Cancer. 15(6):421-5, 2015
                                                                  11. Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
                                                                  12. Guiu S et al: Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions? Crit Rev Oncol Hematol. 92(3):235-257, 2014
                                                                  13. Jung HN et al: Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast? Breast. 22(3):324-9, 2013
                                                                  14. Rakha EA et al: Pleomorphic lobular carcinoma of the breast: is it a prognostically significant pathological subtype independent of histological grade? Mod Pathol. 26(4):496-501, 2013
                                                                  15. Jacobs M et al: Clinicopathologic and biomarker analysis of invasive pleomorphic lobular carcinoma as compared with invasive classic lobular carcinoma: an experience in our institution and review of the literature. Ann Diagn Pathol. 16(3):185-9, 2012
                                                                  16. Jung HN et al: Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast? Breast. Epub ahead of print, 2012
                                                                  17. Jung SP et al: Invasive pleomorphic lobular carcinoma of the breast: clinicopathologic characteristics and prognosis compared with invasive ductal carcinoma. J Breast Cancer. 15(3):313-9, 2012
                                                                  18. Monhollen L et al: Pleomorphic lobular carcinoma: a distinctive clinical and molecular breast cancer type. Histopathology. 61(3):365-77, 2012
                                                                  19. Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
                                                                  20. Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
                                                                  21. Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
                                                                  22. Lopez JK et al: Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 29(1):165-76, 2009
                                                                  23. Vargas AC et al: Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact. Future Oncol. 5(2):233-43, 2009
                                                                  24. Buchanan CL et al: Is pleomorphic lobular carcinoma really a distinct clinical entity? J Surg Oncol. 98(5):314-7, 2008
                                                                  25. Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
                                                                  26. Maly B et al: Pleomorphic variant of invasive lobular carcinoma of the male breast. Virchows Arch. 446(3):344-5, 2005
                                                                  27. Moe RE et al: Distinctive biology of pleomorphic lobular carcinoma of the breast. J Surg Oncol. 90(2):47-50, 2005
                                                                  28. Reis-Filho JS et al: Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity. J Pathol. 207(1):1-13, 2005
                                                                  29. Varga Z et al: Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer. Histopathology. 44(4):332-8, 2004
                                                                  30. Tot T: The diffuse type of invasive lobular carcinoma of the breast: morphology and prognosis. Virchows Arch. 443(6):718-24, 2003
                                                                  31. Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
                                                                  32. Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001