IMPC: Aggressive, morphologically distinct variant of invasive ductal cancer (IDC) (but not special type per se)
Aggregates of tumor cells lying in clear spaces that mimic lymphovascular invasion
Distinct from micropapillary DCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Kaya C et al: The impact of micropapillary component ratio on the prognosis of patients with invasive micropapillary breast carcinoma. J Invest Surg. 1-9, 2018
Wu Y et al: The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis. BMC Cancer. 17(1):839, 2017
Yang YL et al: Invasive Micropapillary Carcinoma of the Breast: An Update. Arch Pathol Lab Med. 140(8):799-805, 2016
Cui ZQ et al: Clinicopathological features of invasive micropapillary carcinoma of the breast. Oncol Lett. 9(3):1163-1166, 2015
Liu F et al: Invasive micropapillary mucinous carcinoma of the breast is associated with poor prognosis. Breast Cancer Res Treat. 151(2):443-51, 2015
Alsharif S et al: Mammographic, sonographic and MR imaging features of invasive micropapillary breast cancer. Eur J Radiol. 83(8):1375-80, 2014
Chen AC et al: Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer. 111(3):619-22, 2014
Liu Y et al: Similar prognoses for invasive micropapillary breast carcinoma and pure invasive ductal carcinoma: a retrospectively matched cohort study in China. PLoS One. 9(9):e106564, 2014
Taketani K et al: A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. World J Surg Oncol. 12:84, 2014
Jones KN et al: Invasive micropapillary carcinoma of the breast: imaging features with clinical and pathologic correlation. AJR Am J Roentgenol. 200(3):689-95, 2013
Lim HS et al: Invasive micropapillary carcinoma of the breast: MR imaging findings. Korean J Radiol. 14(4):551-8, 2013
Adrada B et al: Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol. 193(1):W58-63, 2009
Lui PC et al: Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Pathology. 39(4):401-5, 2007
Guo X et al: Invasive micropapillary carcinoma of the breast: association of pathologic features with lymph node metastasis. Am J Clin Pathol. 126(5):740-6, 2006
Kim MJ et al: Immunohistochemical and clinicopathologic characteristics of invasive ductal carcinoma of breast with micropapillary carcinoma component. Arch Pathol Lab Med. 129(10):1277-82, 2005
Nagi C et al: N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3):225-35, 2005
Kuroda H et al: Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 11(2):169-74, 2004
Kuroda H et al: Overexpression of Her2/neu, estrogen and progesterone receptors in invasive micropapillary carcinoma of the breast. Breast Cancer. 11(3):301-6, 2004
Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 11(6):297-303, 2004
Pettinato G et al: Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol. 121(6):857-66, 2004
Zekioglu O et al: Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology. 44(1):18-23, 2004
Günhan-Bilgen I et al: Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 179(4):927-31, 2002
Jaffer S et al: Infiltrating micropapillary carcinoma of the breast. Cytologic findings. Acta Cytol. 46(6):1081-7, 2002
Walsh MM et al: Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol. 32(6):583-9, 2001
Siriaunkgul S et al: Invasive micropapillary carcinoma of the breast. Mod Pathol. 6(6):660-2, 1993
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TERMINOLOGY
Abbreviations
Invasive micropapillary carcinoma (IMPC)
Definitions
IMPC: Aggressive, morphologically distinct variant of invasive ductal cancer (IDC) (but not special type per se)
Aggregates of tumor cells lying in clear spaces that mimic lymphovascular invasion
Distinct from micropapillary DCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Kaya C et al: The impact of micropapillary component ratio on the prognosis of patients with invasive micropapillary breast carcinoma. J Invest Surg. 1-9, 2018
Wu Y et al: The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis. BMC Cancer. 17(1):839, 2017
Yang YL et al: Invasive Micropapillary Carcinoma of the Breast: An Update. Arch Pathol Lab Med. 140(8):799-805, 2016
Cui ZQ et al: Clinicopathological features of invasive micropapillary carcinoma of the breast. Oncol Lett. 9(3):1163-1166, 2015
Liu F et al: Invasive micropapillary mucinous carcinoma of the breast is associated with poor prognosis. Breast Cancer Res Treat. 151(2):443-51, 2015
Alsharif S et al: Mammographic, sonographic and MR imaging features of invasive micropapillary breast cancer. Eur J Radiol. 83(8):1375-80, 2014
Chen AC et al: Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer. 111(3):619-22, 2014
Liu Y et al: Similar prognoses for invasive micropapillary breast carcinoma and pure invasive ductal carcinoma: a retrospectively matched cohort study in China. PLoS One. 9(9):e106564, 2014
Taketani K et al: A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. World J Surg Oncol. 12:84, 2014
Jones KN et al: Invasive micropapillary carcinoma of the breast: imaging features with clinical and pathologic correlation. AJR Am J Roentgenol. 200(3):689-95, 2013
Lim HS et al: Invasive micropapillary carcinoma of the breast: MR imaging findings. Korean J Radiol. 14(4):551-8, 2013
Adrada B et al: Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol. 193(1):W58-63, 2009
Lui PC et al: Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Pathology. 39(4):401-5, 2007
Guo X et al: Invasive micropapillary carcinoma of the breast: association of pathologic features with lymph node metastasis. Am J Clin Pathol. 126(5):740-6, 2006
Kim MJ et al: Immunohistochemical and clinicopathologic characteristics of invasive ductal carcinoma of breast with micropapillary carcinoma component. Arch Pathol Lab Med. 129(10):1277-82, 2005
Nagi C et al: N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3):225-35, 2005
Kuroda H et al: Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 11(2):169-74, 2004
Kuroda H et al: Overexpression of Her2/neu, estrogen and progesterone receptors in invasive micropapillary carcinoma of the breast. Breast Cancer. 11(3):301-6, 2004
Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 11(6):297-303, 2004
Pettinato G et al: Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol. 121(6):857-66, 2004
Zekioglu O et al: Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology. 44(1):18-23, 2004
Günhan-Bilgen I et al: Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 179(4):927-31, 2002
Jaffer S et al: Infiltrating micropapillary carcinoma of the breast. Cytologic findings. Acta Cytol. 46(6):1081-7, 2002
Walsh MM et al: Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol. 32(6):583-9, 2001
Siriaunkgul S et al: Invasive micropapillary carcinoma of the breast. Mod Pathol. 6(6):660-2, 1993
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