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Breast
Histopathologic Diagnoses
Malignant Lesions
Invasive Micropapillary Carcinoma
Invasive Micropapillary Carcinoma
Jessica W. T. Leung, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Scanning Tips

              TERMINOLOGY

              • Abbreviations

                • Invasive micropapillary carcinoma (IMPC)

              • Definitions

                • IMPC: Aggressive, morphologically distinct variant of invasive ductal cancer (IDC) (but not special type per se)
                  • Aggregates of tumor cells lying in clear spaces that mimic lymphovascular invasion
                • Distinct from micropapillary DCIS

              IMAGING

              • General Features

                • Mammographic Findings

                  • Ultrasonographic Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Kaya C et al: The impact of micropapillary component ratio on the prognosis of patients with invasive micropapillary breast carcinoma. J Invest Surg. 1-9, 2018
                                        2. Wu Y et al: The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis. BMC Cancer. 17(1):839, 2017
                                        3. Yang YL et al: Invasive Micropapillary Carcinoma of the Breast: An Update. Arch Pathol Lab Med. 140(8):799-805, 2016
                                        4. Cui ZQ et al: Clinicopathological features of invasive micropapillary carcinoma of the breast. Oncol Lett. 9(3):1163-1166, 2015
                                        5. Liu F et al: Invasive micropapillary mucinous carcinoma of the breast is associated with poor prognosis. Breast Cancer Res Treat. 151(2):443-51, 2015
                                        6. Alsharif S et al: Mammographic, sonographic and MR imaging features of invasive micropapillary breast cancer. Eur J Radiol. 83(8):1375-80, 2014
                                        7. Chen AC et al: Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer. 111(3):619-22, 2014
                                        8. Liu Y et al: Similar prognoses for invasive micropapillary breast carcinoma and pure invasive ductal carcinoma: a retrospectively matched cohort study in China. PLoS One. 9(9):e106564, 2014
                                        9. Taketani K et al: A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. World J Surg Oncol. 12:84, 2014
                                        10. Jones KN et al: Invasive micropapillary carcinoma of the breast: imaging features with clinical and pathologic correlation. AJR Am J Roentgenol. 200(3):689-95, 2013
                                        11. Lim HS et al: Invasive micropapillary carcinoma of the breast: MR imaging findings. Korean J Radiol. 14(4):551-8, 2013
                                        12. Adrada B et al: Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol. 193(1):W58-63, 2009
                                        13. Lui PC et al: Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Pathology. 39(4):401-5, 2007
                                        14. Guo X et al: Invasive micropapillary carcinoma of the breast: association of pathologic features with lymph node metastasis. Am J Clin Pathol. 126(5):740-6, 2006
                                        15. Kim MJ et al: Immunohistochemical and clinicopathologic characteristics of invasive ductal carcinoma of breast with micropapillary carcinoma component. Arch Pathol Lab Med. 129(10):1277-82, 2005
                                        16. Nagi C et al: N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3):225-35, 2005
                                        17. Kuroda H et al: Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 11(2):169-74, 2004
                                        18. Kuroda H et al: Overexpression of Her2/neu, estrogen and progesterone receptors in invasive micropapillary carcinoma of the breast. Breast Cancer. 11(3):301-6, 2004
                                        19. Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 11(6):297-303, 2004
                                        20. Pettinato G et al: Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol. 121(6):857-66, 2004
                                        21. Zekioglu O et al: Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology. 44(1):18-23, 2004
                                        22. Günhan-Bilgen I et al: Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 179(4):927-31, 2002
                                        23. Jaffer S et al: Infiltrating micropapillary carcinoma of the breast. Cytologic findings. Acta Cytol. 46(6):1081-7, 2002
                                        24. Walsh MM et al: Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol. 32(6):583-9, 2001
                                        25. Siriaunkgul S et al: Invasive micropapillary carcinoma of the breast. Mod Pathol. 6(6):660-2, 1993
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Scanning Tips

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Invasive micropapillary carcinoma (IMPC)

                                                    • Definitions

                                                      • IMPC: Aggressive, morphologically distinct variant of invasive ductal cancer (IDC) (but not special type per se)
                                                        • Aggregates of tumor cells lying in clear spaces that mimic lymphovascular invasion
                                                      • Distinct from micropapillary DCIS

                                                    IMAGING

                                                    • General Features

                                                      • Mammographic Findings

                                                        • Ultrasonographic Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Kaya C et al: The impact of micropapillary component ratio on the prognosis of patients with invasive micropapillary breast carcinoma. J Invest Surg. 1-9, 2018
                                                                              2. Wu Y et al: The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis. BMC Cancer. 17(1):839, 2017
                                                                              3. Yang YL et al: Invasive Micropapillary Carcinoma of the Breast: An Update. Arch Pathol Lab Med. 140(8):799-805, 2016
                                                                              4. Cui ZQ et al: Clinicopathological features of invasive micropapillary carcinoma of the breast. Oncol Lett. 9(3):1163-1166, 2015
                                                                              5. Liu F et al: Invasive micropapillary mucinous carcinoma of the breast is associated with poor prognosis. Breast Cancer Res Treat. 151(2):443-51, 2015
                                                                              6. Alsharif S et al: Mammographic, sonographic and MR imaging features of invasive micropapillary breast cancer. Eur J Radiol. 83(8):1375-80, 2014
                                                                              7. Chen AC et al: Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer. 111(3):619-22, 2014
                                                                              8. Liu Y et al: Similar prognoses for invasive micropapillary breast carcinoma and pure invasive ductal carcinoma: a retrospectively matched cohort study in China. PLoS One. 9(9):e106564, 2014
                                                                              9. Taketani K et al: A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. World J Surg Oncol. 12:84, 2014
                                                                              10. Jones KN et al: Invasive micropapillary carcinoma of the breast: imaging features with clinical and pathologic correlation. AJR Am J Roentgenol. 200(3):689-95, 2013
                                                                              11. Lim HS et al: Invasive micropapillary carcinoma of the breast: MR imaging findings. Korean J Radiol. 14(4):551-8, 2013
                                                                              12. Adrada B et al: Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol. 193(1):W58-63, 2009
                                                                              13. Lui PC et al: Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Pathology. 39(4):401-5, 2007
                                                                              14. Guo X et al: Invasive micropapillary carcinoma of the breast: association of pathologic features with lymph node metastasis. Am J Clin Pathol. 126(5):740-6, 2006
                                                                              15. Kim MJ et al: Immunohistochemical and clinicopathologic characteristics of invasive ductal carcinoma of breast with micropapillary carcinoma component. Arch Pathol Lab Med. 129(10):1277-82, 2005
                                                                              16. Nagi C et al: N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3):225-35, 2005
                                                                              17. Kuroda H et al: Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 11(2):169-74, 2004
                                                                              18. Kuroda H et al: Overexpression of Her2/neu, estrogen and progesterone receptors in invasive micropapillary carcinoma of the breast. Breast Cancer. 11(3):301-6, 2004
                                                                              19. Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 11(6):297-303, 2004
                                                                              20. Pettinato G et al: Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol. 121(6):857-66, 2004
                                                                              21. Zekioglu O et al: Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology. 44(1):18-23, 2004
                                                                              22. Günhan-Bilgen I et al: Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 179(4):927-31, 2002
                                                                              23. Jaffer S et al: Infiltrating micropapillary carcinoma of the breast. Cytologic findings. Acta Cytol. 46(6):1081-7, 2002
                                                                              24. Walsh MM et al: Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol. 32(6):583-9, 2001
                                                                              25. Siriaunkgul S et al: Invasive micropapillary carcinoma of the breast. Mod Pathol. 6(6):660-2, 1993