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Invasive Mucinous Adenocarcinoma (Diffuse)
Kyung Soo Lee, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Invasive mucinous adenocarcinoma (IMA)
            • Adenocarcinoma (ADC)
          • Synonyms

            • Mucinous bronchioloalveolar carcinoma (BAC)
          • Definitions

            • 2015 World Health Organization (WHO) classification
              • Neoplastic cells with goblet or columnar morphology and abundant intracytoplasmic mucin; often exhibit lepidic-predominant growth with little invasion
              • Lepidic growth: Restricted neoplastic growth along preexisting alveolar structures without stromal, vascular, or pleural invasion
              • Formerly mucinous BAC in 2004 WHO classification

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Lee HY et al: Prognosis in resected invasive mucinous adenocarcinomas of the lung: related factors and comparison with resected nonmucinous adenocarcinomas. J Thorac Oncol. 11(7):1064-73, 2016
                                            2. Travis WD et al: International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6(2):244-85, 2011
                                            3. Lee HY et al: Mucinous versus nonmucinous solitary pulmonary nodular bronchioloalveolar carcinoma: CT and FDG PET findings and pathologic comparisons. Lung Cancer. 65(2):170-5, 2009
                                            4. Gaeta M, Minutoli F, Ascenti G, Vinci S, Mazziotti S, Pandolfo I, BlandinoA. MR white lung sign: incidence and significance in pulmonary consolidations.J Comput Assist Tomogr. 2001 Nov-Dec;25(6):890-6.
                                            5. Lee KS et al: Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings. Radiographics. 17(6):1345-57, 1997
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Invasive mucinous adenocarcinoma (IMA)
                                                      • Adenocarcinoma (ADC)
                                                    • Synonyms

                                                      • Mucinous bronchioloalveolar carcinoma (BAC)
                                                    • Definitions

                                                      • 2015 World Health Organization (WHO) classification
                                                        • Neoplastic cells with goblet or columnar morphology and abundant intracytoplasmic mucin; often exhibit lepidic-predominant growth with little invasion
                                                        • Lepidic growth: Restricted neoplastic growth along preexisting alveolar structures without stromal, vascular, or pleural invasion
                                                        • Formerly mucinous BAC in 2004 WHO classification

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Lee HY et al: Prognosis in resected invasive mucinous adenocarcinomas of the lung: related factors and comparison with resected nonmucinous adenocarcinomas. J Thorac Oncol. 11(7):1064-73, 2016
                                                                                      2. Travis WD et al: International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6(2):244-85, 2011
                                                                                      3. Lee HY et al: Mucinous versus nonmucinous solitary pulmonary nodular bronchioloalveolar carcinoma: CT and FDG PET findings and pathologic comparisons. Lung Cancer. 65(2):170-5, 2009
                                                                                      4. Gaeta M, Minutoli F, Ascenti G, Vinci S, Mazziotti S, Pandolfo I, BlandinoA. MR white lung sign: incidence and significance in pulmonary consolidations.J Comput Assist Tomogr. 2001 Nov-Dec;25(6):890-6.
                                                                                      5. Lee KS et al: Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings. Radiographics. 17(6):1345-57, 1997