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Invasive Pituitary Macroadenoma
C. Douglas Phillips, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Invasive giant macroadenoma
            • Definitions

              • Invasive benign pituitary macroadenoma with inferior extension into skull base

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Sav A et al: Invasive, atypical and aggressive pituitary adenomas and carcinomas. Endocrinol Metab Clin North Am. 44(1):99-104, 2015
                                        2. Hornyak M et al: Multimodality treatment for invasive pituitary adenomas. Postgrad Med. 121(2):168-76, 2009
                                        3. Gürlek A et al: What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics. Eur J Endocrinol. 156(2):143-53, 2007
                                        4. Nakasu Y et al: Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. AJNR Am J Neuroradiol. 22(8):1528-33, 2001
                                        5. Yokoyama S et al: Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery. 49(4):857-62; discussion 862-3, 2001
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Invasive giant macroadenoma
                                                  • Definitions

                                                    • Invasive benign pituitary macroadenoma with inferior extension into skull base

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Sav A et al: Invasive, atypical and aggressive pituitary adenomas and carcinomas. Endocrinol Metab Clin North Am. 44(1):99-104, 2015
                                                                              2. Hornyak M et al: Multimodality treatment for invasive pituitary adenomas. Postgrad Med. 121(2):168-76, 2009
                                                                              3. Gürlek A et al: What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics. Eur J Endocrinol. 156(2):143-53, 2007
                                                                              4. Nakasu Y et al: Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. AJNR Am J Neuroradiol. 22(8):1528-33, 2001
                                                                              5. Yokoyama S et al: Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery. 49(4):857-62; discussion 862-3, 2001