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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Molluscum fibrosum, mesenchymal dysplasia, fibromatosis hyalinica multiplex juvenilis, Puretic syndrome, systemic hyalinosis, hyaline fibromatosis syndrome, infantile systemic hyalinosis, disseminated painful fibromatosis, multiple fibromata
Definitions
- Rare congenital disease producing subcutaneous tumors, gingiva hypertrophy, lytic bone lesions, and flexion joint contractures
IMAGING
General Features
Radiographic Findings
MR Findings
Sonography
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Liu Y et al: Hyaline fibromatosis syndrome: a case presenting with gingival enlargement as the only clinical manifestation and a report of two new mutations in the ANTXR2 gene. BMC Oral Health. 21(1):508, 2021
- Mendiratta V et al: Multiple scalp tumors in juvenile hyaline fibromatosis with antxr-2 mutation in a family. Indian J Dermatol. 66(3):330, 2021
- Song L et al: Juvenile hyaline fibromatosis: a clinicopathological study of five cases. Ann Diagn Pathol. 55:151835, 2021
- Braizat O et al: Juvenile hyaline fibromatosis: literature review and a case treated with surgical excision and corticosteroid. Cureus. 12(10):e10823, 2020
- Davis JL: Juvenile hyaline fibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 63-4, 2020
- Castiglione D et al: Hyaline fibromatosis syndrome (juvenile hyaline fibromatosis): whole-body MR findings in two siblings with different subcutaneous nodules distribution. Skeletal Radiol. 47(3):425-31, 2018
- Çam B et al: Juvenile hyaline fibromatosis: a case report follow-up after 3 years and a review of the literature. Int J Dermatol. 54(2):217-21, 2015
- Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 255-7, 2014
- Jaouad IC et al: Hyaline fibromatosis syndrome with mutation c.1074delT of the CMG2 gene: a case report. J Med Case Rep. 8:291, 2014
- Raeeskarami SR et al: Infantile systemic hyalinosis: report of 17-year experience. Iran J Pediatr. 24(6):775-8, 2014
- Van Raak SM et al: Hyaline fibromatosis of Hoffa's fat pad in a patient with a mild type of hyaline fibromatosis syndrome. Skeletal Radiol. 43(4):531-4, 2014
- Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 269-72, 2008
- O' Connell J: Juvenile hyaline fibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 63-4, 2002
- Keser G et al: Two siblings with juvenile hyaline fibromatosis: case reports and review of the literature. Clin Rheumatol. 18(3):248-52, 1999
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Molluscum fibrosum, mesenchymal dysplasia, fibromatosis hyalinica multiplex juvenilis, Puretic syndrome, systemic hyalinosis, hyaline fibromatosis syndrome, infantile systemic hyalinosis, disseminated painful fibromatosis, multiple fibromata
Definitions
- Rare congenital disease producing subcutaneous tumors, gingiva hypertrophy, lytic bone lesions, and flexion joint contractures
IMAGING
General Features
Radiographic Findings
MR Findings
Sonography
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Liu Y et al: Hyaline fibromatosis syndrome: a case presenting with gingival enlargement as the only clinical manifestation and a report of two new mutations in the ANTXR2 gene. BMC Oral Health. 21(1):508, 2021
- Mendiratta V et al: Multiple scalp tumors in juvenile hyaline fibromatosis with antxr-2 mutation in a family. Indian J Dermatol. 66(3):330, 2021
- Song L et al: Juvenile hyaline fibromatosis: a clinicopathological study of five cases. Ann Diagn Pathol. 55:151835, 2021
- Braizat O et al: Juvenile hyaline fibromatosis: literature review and a case treated with surgical excision and corticosteroid. Cureus. 12(10):e10823, 2020
- Davis JL: Juvenile hyaline fibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 63-4, 2020
- Castiglione D et al: Hyaline fibromatosis syndrome (juvenile hyaline fibromatosis): whole-body MR findings in two siblings with different subcutaneous nodules distribution. Skeletal Radiol. 47(3):425-31, 2018
- Çam B et al: Juvenile hyaline fibromatosis: a case report follow-up after 3 years and a review of the literature. Int J Dermatol. 54(2):217-21, 2015
- Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 255-7, 2014
- Jaouad IC et al: Hyaline fibromatosis syndrome with mutation c.1074delT of the CMG2 gene: a case report. J Med Case Rep. 8:291, 2014
- Raeeskarami SR et al: Infantile systemic hyalinosis: report of 17-year experience. Iran J Pediatr. 24(6):775-8, 2014
- Van Raak SM et al: Hyaline fibromatosis of Hoffa's fat pad in a patient with a mild type of hyaline fibromatosis syndrome. Skeletal Radiol. 43(4):531-4, 2014
- Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 269-72, 2008
- O' Connell J: Juvenile hyaline fibromatosis. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 63-4, 2002
- Keser G et al: Two siblings with juvenile hyaline fibromatosis: case reports and review of the literature. Clin Rheumatol. 18(3):248-52, 1999
