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Kawasaki Disease
Ryan A. Moore, MD; Robert J. Fleck, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Mucocutaneous lymph node syndrome; acute febrile mucocutaneous syndrome
            • Definitions

              • Inflammatory disease of small & medium-sized blood vessels of unknown etiology, occurring mainly in children
                • Manifests mainly with prolonged fever, nonsuppurative conjunctivitis, inflamed mucosal membranes of mouth & lips, cervical lymphadenopathy, maculoerythematous rash, & desquamation of hands & feet

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Echocardiographic Findings

                        • Angiographic Findings

                          • Nuclear Medicine Findings

                            • Imaging Recommendations

                              DIFFERENTIAL DIAGNOSIS

                                PATHOLOGY

                                • General Features

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Newburger JW et al: Kawasaki Disease. J Am Coll Cardiol. 67(14):1738-49, 2016
                                                2. Brown LM et al: A practical guide to pediatric coronary artery imaging with echocardiography. J Am Soc Echocardiogr. 28(4):379-91, 2015
                                                3. Harnden A et al: Kawasaki disease. BMJ. 338:b1514, 2009
                                                4. Mavrogeni S et al: How to image Kawasaki disease: a validation of different imaging techniques. Int J Cardiol. 124(1):27-31, 2008
                                                5. Arnold R et al: Visualization of coronary arteries in patients after childhood Kawasaki syndrome: value of multidetector CT and MR imaging in comparison to conventional coronary catheterization. Pediatr Radiol. 37(10):998-1006, 2007
                                                6. Takemura A et al: Utility of coronary MR angiography in children with Kawasaki disease. AJR Am J Roentgenol. 188(6):W534-9, 2007
                                                7. Newburger JW et al: Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 114(6):1708-33, 2004
                                                8. Greil GF et al: Coronary magnetic resonance angiography in adolescents and young adults with kawasaki disease. Circulation. 105(8):908-11, 2002
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Mucocutaneous lymph node syndrome; acute febrile mucocutaneous syndrome
                                                          • Definitions

                                                            • Inflammatory disease of small & medium-sized blood vessels of unknown etiology, occurring mainly in children
                                                              • Manifests mainly with prolonged fever, nonsuppurative conjunctivitis, inflamed mucosal membranes of mouth & lips, cervical lymphadenopathy, maculoerythematous rash, & desquamation of hands & feet

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Echocardiographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Newburger JW et al: Kawasaki Disease. J Am Coll Cardiol. 67(14):1738-49, 2016
                                                                                              2. Brown LM et al: A practical guide to pediatric coronary artery imaging with echocardiography. J Am Soc Echocardiogr. 28(4):379-91, 2015
                                                                                              3. Harnden A et al: Kawasaki disease. BMJ. 338:b1514, 2009
                                                                                              4. Mavrogeni S et al: How to image Kawasaki disease: a validation of different imaging techniques. Int J Cardiol. 124(1):27-31, 2008
                                                                                              5. Arnold R et al: Visualization of coronary arteries in patients after childhood Kawasaki syndrome: value of multidetector CT and MR imaging in comparison to conventional coronary catheterization. Pediatr Radiol. 37(10):998-1006, 2007
                                                                                              6. Takemura A et al: Utility of coronary MR angiography in children with Kawasaki disease. AJR Am J Roentgenol. 188(6):W534-9, 2007
                                                                                              7. Newburger JW et al: Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 114(6):1708-33, 2004
                                                                                              8. Greil GF et al: Coronary magnetic resonance angiography in adolescents and young adults with kawasaki disease. Circulation. 105(8):908-11, 2002