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Kawasaki Disease
Seth Kligerman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Kawasaki disease (KD)
              • Synonyms

                • Mucocutaneous lymph node syndrome
              • Definitions

                • Self-limited small and medium vessel vasculitis seen in young children aged 6 months to 5 years that can lead to coronary artery aneurysms

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Echocardiographic Findings

                        • Angiographic Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Broncano J et al: CT and MR imaging of cardiothoracic vasculitis. Radiographics. 38(4):997-1021, 2018
                                              2. Goh YG et al: Coronary manifestations of Kawasaki disease in computed tomography coronary angiography. J Cardiovasc Comput Tomogr. 12(4):275-280, 2018
                                              3. Jeudy J et al: Spectrum of coronary artery aneurysms: From the Radiologic Pathology Archives. Radiographics. 38(1):11-36, 2018
                                              4. McCrindle BW et al: The role of echocardiography in Kawasaki disease. Int J Rheum Dis. 21(1):50-55, 2018
                                              5. Tsuda E et al: Role of imaging studies in Kawasaki disease. Int J Rheum Dis. 21(1):56-63, 2018
                                              6. Bratis K et al: Cardiac magnetic resonance feature tracking in Kawasaki disease convalescence. Ann Pediatr Cardiol. 10(1):18-25, 2017
                                              7. Kligerman S et al: Use of model-based iterative reconstruction to improve detection of congenital cardiovascular anomalies in infants undergoing free-breathing computed tomographic angiography. J Thorac Imaging. 32(2):127-135, 2017
                                              8. Cohen E et al: Kawasaki Disease at 50 Years. JAMA Pediatr. 170(11):1093-1099, 2016
                                              9. Gao W et al: Diagnostic accuracy of sub-mSv prospective ECG-triggering cardiac CT in young infant with complex congenital heart disease. Int J Cardiovasc Imaging. 32(6):991-8, 2016
                                              10. Bratis K et al: Abnormal myocardial perfusion in Kawasaki disease convalescence. JACC Cardiovasc Imaging. 8(1):106-8, 2015
                                              11. Dietz SM et al: Cardiovascular imaging in children and adults following Kawasaki disease. Insights Imaging. 6(6):697-705, 2015
                                              12. Jadhav SP et al: CT angiography of neonates and infants: comparison of radiation dose and image quality of target mode prospectively ECG-gated 320-MDCT and ungated helical 64-MDCT. AJR Am J Roentgenol. 204(2):W184-91, 2015
                                              13. Kim JW et al: Coronary artery abnormalities in Kawasaki disease: comparison between CT and MR coronary angiography. Acta Radiol. 54(2):156-63, 2013
                                              14. Mavrogeni S et al: The emerging role of cardiovascular magnetic resonance in the evaluation of Kawasaki disease. Int J Cardiovasc Imaging. 29(8):1787-98, 2013
                                              15. Tacke CE et al: Cardiac magnetic resonance imaging for noninvasive assessment of cardiovascular disease during the follow-up of patients with Kawasaki disease. Circ Cardiovasc Imaging. 4(6):712-20, 2011
                                              16. Johnson PT et al: CT angiography of coronary artery aneurysms: detection, definition, causes, and treatment. AJR Am J Roentgenol. 195(4):928-34, 2010
                                              17. Díaz-Zamudio M et al: Coronary artery aneurysms and ectasia: role of coronary CT angiography. Radiographics. 29(7):1939-54, 2009
                                              18. Goo HW et al: Coronary CT angiography and MR angiography of Kawasaki disease. Pediatr Radiol. 36(7):697-705, 2006
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Kawasaki disease (KD)
                                                          • Synonyms

                                                            • Mucocutaneous lymph node syndrome
                                                          • Definitions

                                                            • Self-limited small and medium vessel vasculitis seen in young children aged 6 months to 5 years that can lead to coronary artery aneurysms

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Echocardiographic Findings

                                                                    • Angiographic Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Broncano J et al: CT and MR imaging of cardiothoracic vasculitis. Radiographics. 38(4):997-1021, 2018
                                                                                          2. Goh YG et al: Coronary manifestations of Kawasaki disease in computed tomography coronary angiography. J Cardiovasc Comput Tomogr. 12(4):275-280, 2018
                                                                                          3. Jeudy J et al: Spectrum of coronary artery aneurysms: From the Radiologic Pathology Archives. Radiographics. 38(1):11-36, 2018
                                                                                          4. McCrindle BW et al: The role of echocardiography in Kawasaki disease. Int J Rheum Dis. 21(1):50-55, 2018
                                                                                          5. Tsuda E et al: Role of imaging studies in Kawasaki disease. Int J Rheum Dis. 21(1):56-63, 2018
                                                                                          6. Bratis K et al: Cardiac magnetic resonance feature tracking in Kawasaki disease convalescence. Ann Pediatr Cardiol. 10(1):18-25, 2017
                                                                                          7. Kligerman S et al: Use of model-based iterative reconstruction to improve detection of congenital cardiovascular anomalies in infants undergoing free-breathing computed tomographic angiography. J Thorac Imaging. 32(2):127-135, 2017
                                                                                          8. Cohen E et al: Kawasaki Disease at 50 Years. JAMA Pediatr. 170(11):1093-1099, 2016
                                                                                          9. Gao W et al: Diagnostic accuracy of sub-mSv prospective ECG-triggering cardiac CT in young infant with complex congenital heart disease. Int J Cardiovasc Imaging. 32(6):991-8, 2016
                                                                                          10. Bratis K et al: Abnormal myocardial perfusion in Kawasaki disease convalescence. JACC Cardiovasc Imaging. 8(1):106-8, 2015
                                                                                          11. Dietz SM et al: Cardiovascular imaging in children and adults following Kawasaki disease. Insights Imaging. 6(6):697-705, 2015
                                                                                          12. Jadhav SP et al: CT angiography of neonates and infants: comparison of radiation dose and image quality of target mode prospectively ECG-gated 320-MDCT and ungated helical 64-MDCT. AJR Am J Roentgenol. 204(2):W184-91, 2015
                                                                                          13. Kim JW et al: Coronary artery abnormalities in Kawasaki disease: comparison between CT and MR coronary angiography. Acta Radiol. 54(2):156-63, 2013
                                                                                          14. Mavrogeni S et al: The emerging role of cardiovascular magnetic resonance in the evaluation of Kawasaki disease. Int J Cardiovasc Imaging. 29(8):1787-98, 2013
                                                                                          15. Tacke CE et al: Cardiac magnetic resonance imaging for noninvasive assessment of cardiovascular disease during the follow-up of patients with Kawasaki disease. Circ Cardiovasc Imaging. 4(6):712-20, 2011
                                                                                          16. Johnson PT et al: CT angiography of coronary artery aneurysms: detection, definition, causes, and treatment. AJR Am J Roentgenol. 195(4):928-34, 2010
                                                                                          17. Díaz-Zamudio M et al: Coronary artery aneurysms and ectasia: role of coronary CT angiography. Radiographics. 29(7):1939-54, 2009
                                                                                          18. Goo HW et al: Coronary CT angiography and MR angiography of Kawasaki disease. Pediatr Radiol. 36(7):697-705, 2006