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Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)
Kristine M. Mosier, DMD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Keratocystic odontogenic tumor (KOT)
              • Synonyms

                • Odontogenic keratocyst, primordial cyst
              • Definitions

                • Benign cystic neoplasm of jaw with aggressive behavior and high recurrence rate

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Mosier KM: Magnetic resonance imaging of the maxilla and mandible: signal characteristics and features in the differential diagnosis of common lesions. Top Magn Reson Imaging. 24(1):23-37, 2015
                                            2. Mosier KM: Lesions of the jaw. Semin Ultrasound CT MR. 36(5):444-50, 2015
                                            3. Johnson NR et al: Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 5(1):9-14, 2014
                                            4. Kakimoto N et al: Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws: is it useful? Oral Surg Oral Med Oral Pathol Oral Radiol. 115(1):104-13, 2013
                                            5. Buckley PC et al: Multilocularity as a radiographic marker of the keratocystic odontogenic tumor. J Oral Maxillofac Surg. 70(2):320-4, 2012
                                            6. Srinivasan K et al: Diffusion-weighted imaging in the evaluation of odontogenic cysts and tumours. Br J Radiol. 85(1018):e864-70, 2012
                                            7. Ariji Y et al: Imaging features contributing to the diagnosis of ameloblastomas and keratocystic odontogenic tumours: logistic regression analysis. Dentomaxillofac Radiol. 40(3):133-40, 2011
                                            8. Kuroyanagi N et al: Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation. J Oral Pathol Med. 38(4):386-92, 2009
                                            9. Slootweg PJ: Lesions of the jaws. Histopathology. 54(4):401-18, 2009
                                            10. González-Alva P et al: Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 50(2):205-12, 2008
                                            11. Sumi M et al: Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions. AJNR Am J Neuroradiol. 29(10):1897-901, 2008
                                            12. Yagyuu T et al: Recurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway. Pathobiology. 75(3):171-6, 2008
                                            13. Henley J et al: Molecular evidence supporting the neoplastic nature of odontogenic keratocyst: a laser capture microdissection study of 15 cases. Histopathology. 47(6):582-6, 2005
                                            14. Hisatomi M et al: MR imaging of epithelial cysts of the oral and maxillofacial region. Eur J Radiol. 48(2):178-82, 2003
                                            15. Blanas N et al: Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90(5): 553-8, 2000
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Keratocystic odontogenic tumor (KOT)
                                                        • Synonyms

                                                          • Odontogenic keratocyst, primordial cyst
                                                        • Definitions

                                                          • Benign cystic neoplasm of jaw with aggressive behavior and high recurrence rate

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Mosier KM: Magnetic resonance imaging of the maxilla and mandible: signal characteristics and features in the differential diagnosis of common lesions. Top Magn Reson Imaging. 24(1):23-37, 2015
                                                                                      2. Mosier KM: Lesions of the jaw. Semin Ultrasound CT MR. 36(5):444-50, 2015
                                                                                      3. Johnson NR et al: Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 5(1):9-14, 2014
                                                                                      4. Kakimoto N et al: Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws: is it useful? Oral Surg Oral Med Oral Pathol Oral Radiol. 115(1):104-13, 2013
                                                                                      5. Buckley PC et al: Multilocularity as a radiographic marker of the keratocystic odontogenic tumor. J Oral Maxillofac Surg. 70(2):320-4, 2012
                                                                                      6. Srinivasan K et al: Diffusion-weighted imaging in the evaluation of odontogenic cysts and tumours. Br J Radiol. 85(1018):e864-70, 2012
                                                                                      7. Ariji Y et al: Imaging features contributing to the diagnosis of ameloblastomas and keratocystic odontogenic tumours: logistic regression analysis. Dentomaxillofac Radiol. 40(3):133-40, 2011
                                                                                      8. Kuroyanagi N et al: Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation. J Oral Pathol Med. 38(4):386-92, 2009
                                                                                      9. Slootweg PJ: Lesions of the jaws. Histopathology. 54(4):401-18, 2009
                                                                                      10. González-Alva P et al: Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 50(2):205-12, 2008
                                                                                      11. Sumi M et al: Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions. AJNR Am J Neuroradiol. 29(10):1897-901, 2008
                                                                                      12. Yagyuu T et al: Recurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway. Pathobiology. 75(3):171-6, 2008
                                                                                      13. Henley J et al: Molecular evidence supporting the neoplastic nature of odontogenic keratocyst: a laser capture microdissection study of 15 cases. Histopathology. 47(6):582-6, 2005
                                                                                      14. Hisatomi M et al: MR imaging of epithelial cysts of the oral and maxillofacial region. Eur J Radiol. 48(2):178-82, 2003
                                                                                      15. Blanas N et al: Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90(5): 553-8, 2000