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Head and Neck
Diagnosis
Lymph Nodes
Infectious and Inflammatory Lesions
Kimura Disease
Kimura Disease
Luke N. Ledbetter, MD; Sara Strauss, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Kimura disease (KD)

              • Synonyms

                • Eosinophilic hyperplastic lymphogranuloma, eosinophilic lymphogranuloma, eosinophilic folliculosis

              • Definitions

                • Angiolymphoid proliferation with peripheral eosinophilia and elevated IgE
                • Benign chronic inflammatory disorder resulting in multiple head and neck masses
                  • Primarily in young Asian male patients

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Sangwan A et al: Kimura disease: a case series and systematic review of clinico-radiological features. Curr Probl Diagn Radiol. ePub, 2020
                                              2. Zhang G et al: Clinical analysis of Kimura's disease in 24 cases from China. BMC Surg. 20(1):1, 2020
                                              3. Zhang X et al: The clinicopathological characteristics of Kimura disease in Chinese patients. Clin Rheumatol. 38(12):3661-7, 2019
                                              4. Lin YY et al: Kimura's disease: clinical and imaging parameters for the prediction of disease recurrence. Clin Imaging. 36(4):272-8, 2012
                                              5. Park SW et al: Kimura disease: CT and MR imaging findings. AJNR Am J Neuroradiol. 33(4):784-8, 2012
                                              6. Horikoshi T et al: Head and neck MRI of Kimura disease. Br J Radiol. 84(1005):800-4, 2011
                                              7. Müller-Richter UD et al: Kimura's disease in a white man. Head Neck. 33(1):138-40, 2011
                                              8. Mrówka-Kata K et al: Kikuchi-Fujimoto and Kimura diseases: the selected, rare causes of neck lymphadenopathy. Eur Arch Otorhinolaryngol. 267(1):5-11, 2010
                                              9. Pitak-Arnnop P et al: Head and neck lesions of Kimura's disease: exclusion of human herpesvirus-8 and Epstein-Barr virus by in situ hybridisation and polymerase chain reaction. An immunohistochemical study. J Craniomaxillofac Surg. 38(4):266-70, 2010
                                              10. Gopinathan A et al: Kimura's disease: imaging patterns on computed tomography. Clin Radiol. 64(10):994-9, 2009
                                              11. Sun QF et al: Kimura disease: review of the literature. Intern Med J. 38(8):668-72, 2008
                                              12. Arshad AR: Kimura's disease of parotid gland presenting as solitary parotid swelling. Head Neck. 25(9):754-7, 2003
                                              13. Ching AS et al: Extranodal manifestation of Kimura's disease: ultrasound features. Eur Radiol. 12(3):600-4, 2002
                                              14. Shetty AK et al: Kimura's disease: a diagnostic challenge. Pediatrics. 110(3):e39, 2002
                                              15. Ahuja A et al: Gray scale and power Doppler sonography in cases of Kimura disease. AJNR Am J Neuroradiol. 22(3):513-7, 2001
                                              16. Buggage RR et al: Kimura disease of the orbit and ocular adnexa. Surv Ophthalmol. 44(1):79-91, 1999
                                              17. Hiwatashi A et al: Kimura's disease with bilateral auricular masses. AJNR Am J Neuroradiol. 20(10):1976-8, 1999
                                              18. Armstrong WB et al: Kimura's disease: two case reports and a literature review. Ann Otol Rhinol Laryngol. 107(12):1066-71, 1998
                                              19. Goldenberg D et al: Computerized tomographic and ultrasonographic features of Kimura's disease. J Laryngol Otol. 111(4):389-91, 1997
                                              20. Li TJ et al: Kimura's disease: a clinicopathologic study of 54 Chinese patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 82(5):549-55, 1996
                                              21. Takahashi S et al: Kimura disease: CT and MR findings. AJNR Am J Neuroradiol. 17(2):382-5, 1996
                                              22. Ahuja AT et al: Ultrasound of Kimura's disease. Clin Radiol. 50(3):170-3, 1995
                                              23. Som PM et al: Kimura disease involving parotid gland and cervical nodes: CT and MR findings. J Comput Assist Tomogr. 16(2):320-2, 1992
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Kimura disease (KD)

                                                          • Synonyms

                                                            • Eosinophilic hyperplastic lymphogranuloma, eosinophilic lymphogranuloma, eosinophilic folliculosis

                                                          • Definitions

                                                            • Angiolymphoid proliferation with peripheral eosinophilia and elevated IgE
                                                            • Benign chronic inflammatory disorder resulting in multiple head and neck masses
                                                              • Primarily in young Asian male patients

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Sangwan A et al: Kimura disease: a case series and systematic review of clinico-radiological features. Curr Probl Diagn Radiol. ePub, 2020
                                                                                          2. Zhang G et al: Clinical analysis of Kimura's disease in 24 cases from China. BMC Surg. 20(1):1, 2020
                                                                                          3. Zhang X et al: The clinicopathological characteristics of Kimura disease in Chinese patients. Clin Rheumatol. 38(12):3661-7, 2019
                                                                                          4. Lin YY et al: Kimura's disease: clinical and imaging parameters for the prediction of disease recurrence. Clin Imaging. 36(4):272-8, 2012
                                                                                          5. Park SW et al: Kimura disease: CT and MR imaging findings. AJNR Am J Neuroradiol. 33(4):784-8, 2012
                                                                                          6. Horikoshi T et al: Head and neck MRI of Kimura disease. Br J Radiol. 84(1005):800-4, 2011
                                                                                          7. Müller-Richter UD et al: Kimura's disease in a white man. Head Neck. 33(1):138-40, 2011
                                                                                          8. Mrówka-Kata K et al: Kikuchi-Fujimoto and Kimura diseases: the selected, rare causes of neck lymphadenopathy. Eur Arch Otorhinolaryngol. 267(1):5-11, 2010
                                                                                          9. Pitak-Arnnop P et al: Head and neck lesions of Kimura's disease: exclusion of human herpesvirus-8 and Epstein-Barr virus by in situ hybridisation and polymerase chain reaction. An immunohistochemical study. J Craniomaxillofac Surg. 38(4):266-70, 2010
                                                                                          10. Gopinathan A et al: Kimura's disease: imaging patterns on computed tomography. Clin Radiol. 64(10):994-9, 2009
                                                                                          11. Sun QF et al: Kimura disease: review of the literature. Intern Med J. 38(8):668-72, 2008
                                                                                          12. Arshad AR: Kimura's disease of parotid gland presenting as solitary parotid swelling. Head Neck. 25(9):754-7, 2003
                                                                                          13. Ching AS et al: Extranodal manifestation of Kimura's disease: ultrasound features. Eur Radiol. 12(3):600-4, 2002
                                                                                          14. Shetty AK et al: Kimura's disease: a diagnostic challenge. Pediatrics. 110(3):e39, 2002
                                                                                          15. Ahuja A et al: Gray scale and power Doppler sonography in cases of Kimura disease. AJNR Am J Neuroradiol. 22(3):513-7, 2001
                                                                                          16. Buggage RR et al: Kimura disease of the orbit and ocular adnexa. Surv Ophthalmol. 44(1):79-91, 1999
                                                                                          17. Hiwatashi A et al: Kimura's disease with bilateral auricular masses. AJNR Am J Neuroradiol. 20(10):1976-8, 1999
                                                                                          18. Armstrong WB et al: Kimura's disease: two case reports and a literature review. Ann Otol Rhinol Laryngol. 107(12):1066-71, 1998
                                                                                          19. Goldenberg D et al: Computerized tomographic and ultrasonographic features of Kimura's disease. J Laryngol Otol. 111(4):389-91, 1997
                                                                                          20. Li TJ et al: Kimura's disease: a clinicopathologic study of 54 Chinese patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 82(5):549-55, 1996
                                                                                          21. Takahashi S et al: Kimura disease: CT and MR findings. AJNR Am J Neuroradiol. 17(2):382-5, 1996
                                                                                          22. Ahuja AT et al: Ultrasound of Kimura's disease. Clin Radiol. 50(3):170-3, 1995
                                                                                          23. Som PM et al: Kimura disease involving parotid gland and cervical nodes: CT and MR findings. J Comput Assist Tomogr. 16(2):320-2, 1992