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Head and Neck
Diagnosis
Temporal Bone
Inner Ear
Infectious and Inflammatory Lesions
Labyrinthine Ossificans
Labyrinthine Ossificans
Bernadette L. Koch, MD; Troy A. Hutchins, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Labyrinthine ossificans (LO)

              • Synonyms

                • Labyrinthine ossification, ossifying labyrinthitis, labyrinthitis ossificans, chronic labyrinthitis

              • Definitions

                • Membranous labyrinth ossification as healing response to infectious, inflammatory, traumatic, or surgical insult to inner ear

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Orman G et al: Accuracy of MR imaging for detection of sensorineural hearing loss in infants with bacterial meningitis. AJNR Am J Neuroradiol. 41(6):1081-6, 2020
                                          2. Chandrasekhar SS et al: Clinical practice guideline: sudden hearing loss (update) executive summary. Otolaryngol Head Neck Surg. 161(2):195-210, 2019
                                          3. Bloch SL et al: Labyrinthitis ossificans: on the mechanism of perilabyrinthine bone remodeling. Ann Otol Rhinol Laryngol. 124(8):649-54, 2015
                                          4. Jiang ZY et al: Utility of MRIs in adult cochlear implant evaluations. Otol Neurotol. 35(9):1533-5, 2014
                                          5. Lin HY et al: The incidence of tympanogenic labyrinthitis ossificans. J Laryngol Otol. 128(7):618-20, 2014
                                          6. Young JY et al: Preoperative imaging of sensorineural hearing loss in pediatric candidates for cochlear implantation. Radiographics. 34(5):E133-49, 2014
                                          7. Kopelovich JC et al: Early prediction of postmeningitic hearing loss in children using magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 137(5):441-7, 2011
                                          8. Durisin M et al: Cochlear osteoneogenesis after meningitis in cochlear implant patients: a retrospective analysis. Otol Neurotol. 31(7):1072-8, 2010
                                          9. Philippon D et al: Cochlear implantation in postmeningitic deafness. Otol Neurotol. 31(1):83-7, 2010
                                          10. Saito N et al: Clinical and radiologic manifestations of sickle cell disease in the head and neck. Radiographics. 30(4):1021-34, 2010
                                          11. Isaacson B et al: Labyrinthitis ossificans: how accurate is MRI in predicting cochlear obstruction? Otolaryngol Head Neck Surg. 140(5):692-6, 2009
                                          12. Liu BP et al: Labyrinthitis ossificans in a child with sickle cell disease: CT and MRI findings. Pediatr Radiol. 39(9):999-1001, 2009
                                          13. Ozgen B et al: Complete labyrinthine aplasia: clinical and radiologic findings with review of the literature. AJNR Am J Neuroradiol. 30(4):774-80, 2009
                                          14. Berrettini S et al: Scala vestibuli cochlear implantation in patients with partially ossified cochleas. J Laryngol Otol. 116(11):946-50, 2002
                                          15. Glastonbury CM et al: Imaging findings of cochlear nerve deficiency. AJNR Am J Neuroradiol. 23(4):635-43, 2002
                                          16. Thomas J et al: Evaluation of cochlear implantation in post-meningitic adults. J Laryngol Otol Suppl. 24:27-33, 1999
                                          17. Muren C et al: Postmeningitic labyrinthine ossification primarily affecting the semicircular canals. Eur Radiol. 7(2):208-13, 1997
                                          18. Johnson MH et al: CT of postmeningitic deafness: observations and predictive value of cochlear implants in children. AJNR. 16(1):103-9, 1995
                                          19. Silberman B et al: Role of modern imaging technology in the implementation of pediatric cochlear implants. Ann Otol Rhinol Laryngol. 104(1):42-6, 1995
                                          20. deSouza C et al: Pathology of labyrinthine ossification. J Laryngol Otol. 105(8):621-4, 1991
                                          21. Novak MA et al: Labyrinthine ossification after meningitis: its implications for cochlear implantation. Otolaryngol Head Neck Surg. 103(3):351-6, 1990
                                          22. Steenerson RL et al: Scala vestibuli cochlear implantation for labyrinthine ossification. Am J Otol. 11(5):360-3, 1990
                                          23. Harnsberger HR et al: Cochlear implant candidates: assessment with CT and MR imaging. Radiology. 164(1):53-7, 1987
                                          24. Kotzias SA et al: Labyrinthine ossification: differences between two types of ectopic bone. Am J Otol. 6(6):490-4, 1985
                                          25. Swartz JD et al: Labyrinthine ossification: etiologies and CT findings. Radiology. 157(2):395-8, 1985
                                          26. Becker TS et al: Labyrinthine ossification secondary to childhood bacterial meningitis: implications for cochlear implant surgery. AJNR Am J Neuroradiol. 5(6):739-41, 1984
                                          27. Ibrahim RA et al: Labyrinthine ossificans and cochlear implants. Arch Otolaryngol. 106(2):111-3, 1980
                                          28. Hoffman RA et al: Radiologic diagnosis of labyrinthitis ossificans. Ann Otol Rhinol Laryngol. 88(2 Pt 1):253-7, 1979
                                          29. Suga F et al: Labyrinthitis ossificans. Ann Otol Rhinol Laryngol. 86(1 Pt 1):17-29, 1977
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Labyrinthine ossificans (LO)

                                                      • Synonyms

                                                        • Labyrinthine ossification, ossifying labyrinthitis, labyrinthitis ossificans, chronic labyrinthitis

                                                      • Definitions

                                                        • Membranous labyrinth ossification as healing response to infectious, inflammatory, traumatic, or surgical insult to inner ear

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Orman G et al: Accuracy of MR imaging for detection of sensorineural hearing loss in infants with bacterial meningitis. AJNR Am J Neuroradiol. 41(6):1081-6, 2020
                                                                                  2. Chandrasekhar SS et al: Clinical practice guideline: sudden hearing loss (update) executive summary. Otolaryngol Head Neck Surg. 161(2):195-210, 2019
                                                                                  3. Bloch SL et al: Labyrinthitis ossificans: on the mechanism of perilabyrinthine bone remodeling. Ann Otol Rhinol Laryngol. 124(8):649-54, 2015
                                                                                  4. Jiang ZY et al: Utility of MRIs in adult cochlear implant evaluations. Otol Neurotol. 35(9):1533-5, 2014
                                                                                  5. Lin HY et al: The incidence of tympanogenic labyrinthitis ossificans. J Laryngol Otol. 128(7):618-20, 2014
                                                                                  6. Young JY et al: Preoperative imaging of sensorineural hearing loss in pediatric candidates for cochlear implantation. Radiographics. 34(5):E133-49, 2014
                                                                                  7. Kopelovich JC et al: Early prediction of postmeningitic hearing loss in children using magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 137(5):441-7, 2011
                                                                                  8. Durisin M et al: Cochlear osteoneogenesis after meningitis in cochlear implant patients: a retrospective analysis. Otol Neurotol. 31(7):1072-8, 2010
                                                                                  9. Philippon D et al: Cochlear implantation in postmeningitic deafness. Otol Neurotol. 31(1):83-7, 2010
                                                                                  10. Saito N et al: Clinical and radiologic manifestations of sickle cell disease in the head and neck. Radiographics. 30(4):1021-34, 2010
                                                                                  11. Isaacson B et al: Labyrinthitis ossificans: how accurate is MRI in predicting cochlear obstruction? Otolaryngol Head Neck Surg. 140(5):692-6, 2009
                                                                                  12. Liu BP et al: Labyrinthitis ossificans in a child with sickle cell disease: CT and MRI findings. Pediatr Radiol. 39(9):999-1001, 2009
                                                                                  13. Ozgen B et al: Complete labyrinthine aplasia: clinical and radiologic findings with review of the literature. AJNR Am J Neuroradiol. 30(4):774-80, 2009
                                                                                  14. Berrettini S et al: Scala vestibuli cochlear implantation in patients with partially ossified cochleas. J Laryngol Otol. 116(11):946-50, 2002
                                                                                  15. Glastonbury CM et al: Imaging findings of cochlear nerve deficiency. AJNR Am J Neuroradiol. 23(4):635-43, 2002
                                                                                  16. Thomas J et al: Evaluation of cochlear implantation in post-meningitic adults. J Laryngol Otol Suppl. 24:27-33, 1999
                                                                                  17. Muren C et al: Postmeningitic labyrinthine ossification primarily affecting the semicircular canals. Eur Radiol. 7(2):208-13, 1997
                                                                                  18. Johnson MH et al: CT of postmeningitic deafness: observations and predictive value of cochlear implants in children. AJNR. 16(1):103-9, 1995
                                                                                  19. Silberman B et al: Role of modern imaging technology in the implementation of pediatric cochlear implants. Ann Otol Rhinol Laryngol. 104(1):42-6, 1995
                                                                                  20. deSouza C et al: Pathology of labyrinthine ossification. J Laryngol Otol. 105(8):621-4, 1991
                                                                                  21. Novak MA et al: Labyrinthine ossification after meningitis: its implications for cochlear implantation. Otolaryngol Head Neck Surg. 103(3):351-6, 1990
                                                                                  22. Steenerson RL et al: Scala vestibuli cochlear implantation for labyrinthine ossification. Am J Otol. 11(5):360-3, 1990
                                                                                  23. Harnsberger HR et al: Cochlear implant candidates: assessment with CT and MR imaging. Radiology. 164(1):53-7, 1987
                                                                                  24. Kotzias SA et al: Labyrinthine ossification: differences between two types of ectopic bone. Am J Otol. 6(6):490-4, 1985
                                                                                  25. Swartz JD et al: Labyrinthine ossification: etiologies and CT findings. Radiology. 157(2):395-8, 1985
                                                                                  26. Becker TS et al: Labyrinthine ossification secondary to childhood bacterial meningitis: implications for cochlear implant surgery. AJNR Am J Neuroradiol. 5(6):739-41, 1984
                                                                                  27. Ibrahim RA et al: Labyrinthine ossificans and cochlear implants. Arch Otolaryngol. 106(2):111-3, 1980
                                                                                  28. Hoffman RA et al: Radiologic diagnosis of labyrinthitis ossificans. Ann Otol Rhinol Laryngol. 88(2 Pt 1):253-7, 1979
                                                                                  29. Suga F et al: Labyrinthitis ossificans. Ann Otol Rhinol Laryngol. 86(1 Pt 1):17-29, 1977